Xinhua Xu

ORCID: 0000-0003-0397-8189
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About
Contact & Profiles
Research Areas
  • Radiopharmaceutical Chemistry and Applications
  • Various Chemistry Research Topics
  • Cardiovascular and Diving-Related Complications
  • Cancer, Hypoxia, and Metabolism
  • Chemical Synthesis and Reactions
  • Analytical Chemistry and Chromatography
  • Lung Cancer Treatments and Mutations
  • Congenital Heart Disease Studies
  • Lymphoma Diagnosis and Treatment
  • Bone health and treatments
  • Liver Disease Diagnosis and Treatment
  • Color perception and design
  • Sulfur-Based Synthesis Techniques
  • Takotsubo Cardiomyopathy and Associated Phenomena
  • Synthesis and Biological Evaluation
  • Heme Oxygenase-1 and Carbon Monoxide
  • Liver physiology and pathology
  • Nonlinear Optical Materials Research
  • Trace Elements in Health
  • Organoselenium and organotellurium chemistry
  • PI3K/AKT/mTOR signaling in cancer
  • Hepatitis B Virus Studies
  • Surfactants and Colloidal Systems
  • Chemical and Physical Properties in Aqueous Solutions
  • Advanced Chemical Sensor Technologies

Tongji University
2014-2024

Beijing Hua Xin Hospital
2014

Qingdao University
2014

Affiliated Hospital of Qingdao University
2014

Anhui Medical University
2010

Central South University
2007-2010

Anhui Provincial Hospital
2010

Stony Brook University
2009

Northport VA Medical Center
2009

Peng Huanwu Center for Fundamental Theory
2006

Phosphoinositide 3-kinase (PI3K) p110alpha plays a key role in insulin action and tumorigenesis. Myocyte contraction is initiated by an inward Ca(2+) current (I(Ca,L)) through the voltage-dependent L-type channel (LTCC). The aim of this study was to evaluate whether also controls cardiac contractility regulating LTCC.Genetic ablation (also known as Pik3ca), but not p110beta Pik3cb), myocytes adult mice reduced I(Ca,L) blocked signaling heart. p110alpha-null had number LTCCs on cell surface...

10.1161/circulationaha.109.873380 article EN Circulation 2009-07-14

Contraction of cardiac myocytes is initiated by Ca(2+) entry through the voltage-dependent L-type channel (LTCC). Previous studies have shown that phosphatidylinositol (PI) 3-kinase signaling modulates LTCC function. Because PI 3-kinases are key mediators insulin action, we investigated whether function affected in diabetic animals due to reduced signaling.We used whole-cell patch clamping and biochemical assays compare insulin-deficient mice heterozygous for Ins2(Akita) mutation versus...

10.2337/db06-1629 article EN Diabetes 2007-09-05

Smartphone thermal cameras can be used to observe heat transfer or patterns in crystallization, evaporation, mixing of liquids, and chemical reactions. The experiments described this paper demonstrate that IR imaging provide students with rich learning exploring opportunities would otherwise infeasible too time-consuming. precision sensitivity smartphone are sufficient for use chemistry education. A accessory is worth introducing into the teaching laboratory.

10.1021/acs.jchemed.9b00131 article EN Journal of Chemical Education 2019-10-01

The determination of the solid–liquid phase diagram a binary system is always used as an experiment in undergraduate physical chemistry laboratory courses. However, most diagrams investigated lab are simple eutectic ones, despite fact that complex more common. In this article, cooling curves phenol–t-butanol mixtures measured and found to give three points two congruent melting points. provides students practical way investigate with their own efforts teamwork spirit.

10.1021/ed400598s article EN Journal of Chemical Education 2014-05-09

Coronary artery anomalies (CAAs) are present at birth, but usually asymptomatic and found during coronary angiography or multi-slice computed tomography (MSCT) examinations. Their prevalence is less than 1.3% based published series.1,2 The most common anomaly separate origin of the left anterior descending (LAD) circumflex (LCX) from sinus Valsalva. second LCX right (RCA) We two cases anomalies: one main (LMCA) arising proximal RCA, other LAD originating RCA. A 67-year-old man presented with...

10.3760/cma.j.issn.0366-6999.20133126 article EN cc-by-nc-nd Chinese Medical Journal 2014-06-20

A correction is made for the calculation equation of aggregation numbers SDS at various temperatures proposed by Marcolongo and Mirenda in their paper “Thermodynamics Sodium Dodecyl Sulfate (SDS) Micellization: An Undergraduate Laboratory Experiment”.

10.1021/acs.jchemed.5b00934 article EN Journal of Chemical Education 2016-06-09

The variation in the transference number of H+ (aq) is investigated for different HCl solution concentrations. method scribing graduations on electromigration tubes modified to decrease error experimental measurements, and metallic copper used as anode reduce toxicity environmental impact reagents. For very dilute solutions, correlation between concentration theoretically described using equations derived from Debye–Hückel–Onsager equation ionic molar conductivity, Longsworth's applied...

10.1021/acs.jchemed.3c00826 article EN Journal of Chemical Education 2024-04-10

To introduce peratrial device closure of secundum atrial septal defects (ASD) under the guidance transesophageal echocardiography (TEE) without cardiopulmonary bypass (CPB) in children, and to summarize clinical experiences.A total 115 children with ASD (the occlusion group) underwent through a small sternotomy TEE bypass. Children were followed up closely for 1-13 months. Another 59 had closed during same period. The differences operation duration, convalescence complication between 2...

10.3969/j.issn.1672-7347.2011.06.017 article EN PubMed 2011-06-01

In the presence of catalytic amount cesium hydroxide, hydroselenation terminal alkynes occurred in N,N-dimethylformamide (DMF) at room temperature under nitrogen atmosphere to afford (E)-1-organseleno-1-alkene high yields.The reaction mechanism is that selenols reacted with hydroxide give selenides, which underwent nucleophilic addition form selenium vinylic anion, hydrolyzed product (E)-1-organoselenovinylene and catalyst hydroxide.The method could provide a new expedient way for...

10.6023/cjoc201211028 article EN Chinese Journal of Organic Chemistry 2013-01-01

e17517 Background: The aim of this study was to evaluate the efficacy and safety apanitib in treatment patients with recurrent and/or metastatic head neck squamous cell carcinoma (HNSCC) who failed from one or more lines therapy. Methods: Patients HNSCC after failure at least line therapy were recruited open-label exploratory study. Subjects initially given apatinib 250mg qd until disease progression unacceptable toxicity. Dose reduction 125 mg allowed. Herein, we reported preliminary...

10.1200/jco.2019.37.15_suppl.e17517 article EN Journal of Clinical Oncology 2019-05-20
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