A5005858236- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- Medical Imaging and Analysis
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Meningioma and schwannoma management
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Neurological disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Musculoskeletal pain and rehabilitation
- Cervical and Thoracic Myelopathy
- Shoulder and Clavicle Injuries
- Parkinson's Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Glioma Diagnosis and Treatment
- Management of metastatic bone disease
- Neurofibromatosis and Schwannoma Cases
- Neurosurgical Procedures and Complications
- Spinal Dysraphism and Malformations
- Shoulder Injury and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Genetic Neurodegenerative Diseases
- Head and Neck Surgical Oncology
The Ohio State University Wexner Medical Center
2022-2025
Neurological Surgery
2010-2025
Northwestern University
2010-2024
The Ohio State University
2022-2024
Medical Technologies (Czechia)
2024
NuVasive (United States)
2024
Medtronic (Ireland)
2024
Baylor University
2023
Wills Eye Hospital
2022-2023
Thomas Jefferson University
2022-2023
Abstract Commonly used for Parkinson’s disease (PD), deep brain stimulation (DBS) produces marked clinical benefits when optimized. However, assessing the large number of possible settings (i.e., programming) requires numerous clinic visits. Here, we examine whether functional magnetic resonance imaging (fMRI) can be to predict optimal individual patients. We analyze 3 T fMRI data prospectively acquired as part an observational trial in 67 PD patients using and non-optimal settings....
Magnetic resonance guided focused ultrasound (MRgFUS) thalamotomy is a novel and minimally invasive ablative treatment for essential tremor. The size location of therapeutic lesions producing the optimal clinical benefits while minimizing adverse effects are not known. We examined these relationships in patients with tremor undergoing MRgFUS. studied 66 who underwent MRgFUS between 2012 2017. assessed Clinical Rating Scale Tremor (CRST) scores at 3 months after procedure tracked (sensory,...
OBJECTIVE Seizures are the most common presenting symptom of newly diagnosed WHO Grade II gliomas (low-grade glioma [LGG]) and significantly impair quality life. Although gross-total resection LGG is associated with better seizure control, it remains unclear whether an extent (EOR) “threshold” exists for long-term control. Specifically, what proportion FLAIR-positive tissue in patients must be removed to achieve Engel Class I freedom? To clarify EOR threshold authors analyzed data from a...
OBJECTIVESpinal osteotomies and anterior column realignment (ACR) are procedures that allow preservation or restoration of spine lordosis. Variations these techniques enable different degrees segmental, regional, global sagittal realignment. The authors propose a comprehensive anatomical classification system for ACR its variants based on the level technical complexity invasiveness. This serves as common language platform to standardize clinical radiographic outcomes utilization...
The clinical results of deep brain stimulation (DBS) the subthalamic nucleus (STN) are highly dependent on accurate targeting and target implantation. Several tactics in current use, including image-only and/or electrophysiologically guided approaches using microelectrode recordings (MERs). purpose present study was to make an appraisal imaging only-based versus with addition intraoperative MER-guided STN electrode targeting.
Lateral lumbar interbody fusion (LLIF) is a useful minimally invasive technique for achieving anterior and preserving or restoring lordosis. However, circumferential via posterior instrumentation after an LLIF can be challenging, requiring either repositioning the patient placing pedicle screws in lateral position. Here, authors explore alternative single-position approach: prone (PL) position.A cadaveric feasibility study was performed using 2 human specimens. A retrospective 2-center early...
OBJECTIVE Physicians are more frequently encountering patients who treated with deep brain stimulation (DBS), yet many MRI centers do not routinely perform in this population. This warrants a safety assessment to improve DBS patients’ accessibility MRI, thereby improving their care while simultaneously providing new tool for neuromodulation research. METHODS A phantom simulating patient device (DBS lead model 3387 and IPG Activa PC 37601) was constructed used. Temperature changes at the most...
Study Design: Prospective cohort study. Objective: This study aimed to investigate the durability of postural stability after ASD correction surgery and its’ association with clinical outcomes. Summary Background Data: The prevalence symptomatic adult spinal deformity (ASD) necessitates surgical intervention, aiming correct global balance spinopelvic parameters. Short-term studies have shown improvements in control following surgery, but long-term impact remains unclear. Methods:...
INTRODUCTION: Spinal fusion surgeries are among the top surgical procedures to be associated with substantial blood loss, often requiring transfusions. Varying when patients transfused intra-operatively may alter post-operative course of and decrease rates morbidity mortality despite overall complications We hypothesize that who products earlier in operation will have better outcomes. METHODS: An IRB-approved retrospective chart review was conducted looking at underwent long segment spine...
Purpose: To investigate the incidence, management, and outcomes of eyes with active uveitis central serous chorioretinopathy (CSCR). Methods: Retrospective chart review Results: Of 4,034 patients diagnosed during 8-year study period, 20 (0.5%) had comorbid CSCR, followed for a median 34 months. Patients were stratified based on diagnoses sequence. In Cohort 1, 4 (3 patients) initially later developed CSCR at 65 days following corticosteroid initiation, resolution occurring in all 104 after...
Loss-of-function mutations in SMN1 cause spinal muscular atrophy (SMA), a leading genetic of infant mortality. The related SMN2 gene expresses suboptimal levels functional SMN protein, due to splicing defect. Many SMA patients reach adulthood, and there is also adult-onset (type IV) SMA. There currently no animal model for SMA, the tissue-specific pathogenesis post-developmental deficiency remains elusive. Here, we use an antisense oligonucleotide (ASO) exacerbate mis-splicing....
Neurofibromatosis type 2 (NF2) is a multiple neoplasia syndrome and caused by mutation of the NF2 tumor suppressor gene that encodes for protein merlin. Biallelic inactivation results in development central nervous system tumors, including schwannomas, meningiomas, ependymomas, astrocytomas. Although wide variety missense germline mutations coding sequences can cause loss merlin function, mechanism this functional unknown. To gain insight into mechanisms underlying function NF2, we...
Background The majority of Parkinson's disease patients with deep brain stimulation (DBS) use a monopolar configuration, which presents challenges for EEG and MRI studies. literature reports algorithms to convert bipolar settings. Purpose/Hypothesis To assess responses implanted DBS during fMRI studies using their clinical presumed equivalent settings published conversion recipe. Study Type Prospective. Subjects Thirteen patients. Field Strength/Sequence 1.5T 3T, gradient echo‐planar...
Gaucher disease (GD), the most common lysosomal storage disorder of humans, is caused by mutations in gene coding for enzyme glucocerebrosidase (GCase). Clinical manifestations vary among patients with three types GD, and phenotypic heterogeneity occurs even identical mutations. To gain insight into why we investigated mechanisms underlying net loss GCase catalytic activity cultured skin fibroblasts derived from GD. The findings indicate that correlates its quantitative reduction, rather...