A5045849178- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Autoimmune Neurological Disorders and Treatments
- Glycogen Storage Diseases and Myoclonus
- Hereditary Neurological Disorders
- Neurological diseases and metabolism
- Mitochondrial Function and Pathology
- Botulinum Toxin and Related Neurological Disorders
- Metabolism and Genetic Disorders
- Celiac Disease Research and Management
- Parkinson's Disease and Spinal Disorders
- Advanced MRI Techniques and Applications
- Vector-borne infectious diseases
- Herpesvirus Infections and Treatments
- Virology and Viral Diseases
- Whipple's Disease and Interleukins
- Alzheimer's disease research and treatments
- Long-Term Effects of COVID-19
- RNA regulation and disease
- Congenital limb and hand anomalies
- RNA and protein synthesis mechanisms
- Ocular Diseases and Behçet’s Syndrome
- Functional Brain Connectivity Studies
- Neurological and metabolic disorders
Apollo Hospitals
2021-2024
Sri Ramachandra Institute of Higher Education and Research
2024
University of Toronto
2018-2021
Toronto Western Hospital
2018-2021
University Health Network
2019-2020
Mater Misericordiae University Hospital
2018-2020
Krembil Research Institute
2020
Krembil Foundation
2020
Stanley Medical College
2019
John Wiley & Sons (United States)
2018
Abstract Commonly used for Parkinson’s disease (PD), deep brain stimulation (DBS) produces marked clinical benefits when optimized. However, assessing the large number of possible settings (i.e., programming) requires numerous clinic visits. Here, we examine whether functional magnetic resonance imaging (fMRI) can be to predict optimal individual patients. We analyze 3 T fMRI data prospectively acquired as part an observational trial in 67 PD patients using and non-optimal settings....
Deep brain stimulation (DBS) depends on precise delivery of electrical current to target tissues. However, the specific structures responsible for best outcome are still debated. We applied probabilistic mapping a retrospective, multidisorder DBS dataset assembled over 15 years at our institution (n total = 482 patients; n Parkinson disease 303; dystonia 64; tremor 39; treatment‐resistant depression/anorexia nervosa 76) identify neuroanatomical substrates optimal clinical response. Using...
BackgroundWith growing numbers of patients receiving deep brain stimulation (DBS), radiologists are encountering these neuromodulation devices at an increasing rate. Current MRI safety guidelines, however, limit access in patients.PurposeTo describe (1.5 T and 3 T) experience profile a large cohort participants with active DBS systems characterize the hardware-related artifacts on images from functional MRI.Materials MethodsIn this prospective study, study underwent 1.5- or 3-T (T1-weighted...
Abstract Background ADCY5 ‐related dyskinesia is characterized by early‐onset movement disorders. There currently no validated treatment, but anecdotal clinical reports and biological hypotheses suggest efficacy of caffeine. Objective The aim to obtain further insight into the safety caffeine in patients with dyskinesia. Methods A retrospective study was conducted worldwide 30 a proven mutation who had tried or were taking for Disease characteristics treatment responses assessed through...
The dopamine transporter scan or DaT is abnormal in presynaptic parkinsonism but normal nondegenerative postsynaptic parkinsonism. In this study, we tried to ascertain the impact of on diagnosis and clinical management if semiquantitative analysis scans has any correlation with symptoms.The electronic nonelectronic records patients Plymouth Hospital NHS Trust, United Kingdom, from 2011 2015 were studied find indication, outcome, patients. results assessed visually semiquantitatively by...
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A 57-year old woman presented with left hand pain, periodic leg movement during sleep, gradual onset of stiffness, clumsiness, and falls. Neurological examination showed: generalized rigidity bradykinesia. There was dystonic posturing ideomotor apraxia, as well mirror movements upper limbs stimulus-sensitive myoclonus. The patient had a high-pitched voice hypophonia (Video S1).Experts discuss localization the syndromic diagnosis predict underlying pathology. pathological is then provided...
Since the emergence of coronavirus disease 2019 (COVID-19), a plethora neurological syndromes and complications have been unravelled. Opsoclonus–myoclonus–ataxia syndrome (OMAS) is rare disorder that was first described in 1962 infants by Kinsbourne much more common children than adults. The diagnosed presence three out following four clinical manifestations: opsoclonus; myoclonus and/or ataxia; behavioural changes sleep disturbances; tumours or anti-neuronal antibodies.[1] While...
Stiff-person syndrome (SPS) usually manifests as an autoimmune neuromuscular disorder characterised by pronounced and advancing rigidity, primarily affecting the trunk proximal muscles. There are various clinical subtypes like classic SPS (truncal stiffness, generalised rigidity muscle spasms), partial (stiff-limb syndrome) uncommon forms including progressive encephalomyelitis with myoclonus. Camptocormia, defined forward flexion of spine in upright position that disappears supine position,...
Dear Editor, We present the case of a 33-year-old woman, who presented to our hospital with difficulty in walking and imbalance for 2 years numbness feet past 1.5 years. She was born consanguineous marriage had normal developmental milestones, no medical comorbidities, insignificant family history. The pedigree chart is depicted Figure 1. Extraocular movements indicated mild gaze-evoked nystagmus. Physical examination revealed musculoskeletal deformities. Motor system power, tone, deep...
Abstract Progressive supranuclear palsy (PSP) has emerged as a key area of interest among researchers worldwide, including those in India, who have actively studied the disorder over past several decades. This review meticulously explores extensive range Indian research on PSP up to present and offers insights into both current initiatives potential future directions for managing within region. Historical contributions spanned 80 publications from 1974 2023, encompassing diverse themes...
We report a case to broaden our understanding of the unusual phenotypical spectrum rare genetic ataxia. A 33-year old woman presented with intermittent episodes periorbital twitching for last 30 years and episodic dizziness lasting between 60 seconds each time 25 years. She also got persistent migraines without aura past 15 The was associated visual blurring, nausea, dysarthria. dizzy spells were triggered by stress, caffeine intake, any quick change postures. could occasionally up minutes....
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We thank Dr. Daniel Richter and colleagues for their comments on our recently published Movement Disorders Clinical Practice (MDCP) article.1, 2 welcome any guidance with regard to the diagnosis of atypical parkinsonism given that it can often be difficult especially at first assessment. Often seeing patient over time (“the tincture time”) identify “red flags” help greatly. However, resulting delay in will prove a problem when disease-modifying treatments are available. The is still clinical...