A5082289526- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Neurological diseases and metabolism
- Parkinson's Disease and Spinal Disorders
- Health, Medicine and Society
- Oral and Maxillofacial Pathology
- Cardiovascular Syncope and Autonomic Disorders
- Neuroscience and Neural Engineering
- Oral and gingival health research
- RNA Research and Splicing
- Neurological and metabolic disorders
- Peripheral Neuropathies and Disorders
- Whipple's Disease and Interleukins
- Neurogenetic and Muscular Disorders Research
- Cerebrospinal fluid and hydrocephalus
- Single-cell and spatial transcriptomics
- Genetics and Neurodevelopmental Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Otolaryngology and Infectious Diseases
- Autoimmune Neurological Disorders and Treatments
- Alzheimer's disease research and treatments
- Neurology and Historical Studies
- Cellular transport and secretion
University Hospital of Lausanne
2011-2025
University of Lausanne
2011-2025
Radboud University Medical Center
2024
Radboud University Nijmegen
2024
Janssen (Netherlands)
2024
Universität Innsbruck
2024
Toronto Western Hospital
2016-2022
University of Toronto
2017-2022
Hôpital Orthopédique de la Suisse Romande
2022
University Hospital of Geneva
2013-2021
Background: Oral microbiota has largely escaped attention in Parkinson’s disease (PD), despite its pivotal role maintaining oral and systemic health. Objective: The aim of our study was to examine the composition degree inflammation PD. Methods: Twenty PD patients were compared 20 healthy controls. Neurological, periodontal dental examinations performed as well scaling gingival crevicular fluid sampling for cytokines measurement (interleukine (IL)-1β, IL-6, IL-1 receptor antagonist (RA),...
Disruption of subthalamic nucleus dynamics in Parkinson’s disease leads to impairments during walking. Here, we aimed uncover the principles through which encodes functional and dysfunctional walking people with disease. We conceived a neurorobotic platform embedding an isokinetic dynamometric chair that allowed us deconstruct key components under well-controlled conditions. exploited this 18 patients demonstrate initiation, termination, amplitude leg muscle activation. found same...
Orthostatic hypotension is a cardinal feature of multiple-system atrophy. The upright posture provokes syncopal episodes that prevent patients from standing and walking for more than brief periods. We implanted system to restore regulation blood pressure enable patient with atrophy stand walk after having lost these abilities because orthostatic hypotension. This involved epidural electrical stimulation delivered over the thoracic spinal cord accelerometers detected changes in body position....
Objective To characterize neurophysiological subcortical abnormalities in myoclonus–dystonia and their modulation by alcohol administration. Methods Cerebellar associative learning basal ganglia–brainstem interaction were investigated 17 patients with epsilon‐sarcoglycan ( SGCE ) gene mutation 21 age‐ sex‐matched healthy controls means of classical eyeblink conditioning blink reflex recovery cycle before after intake resulting a breath concentration 0.08% (0.8g/l). The responsiveness...
To delineate autoimmune disease in association with contactin-associated protein 2 (CASPR2) antibodies childhood, we reviewed the clinical phenotype of children CASPR2 antibodies.Retrospective assessment patients recruited through laboratories specialized CNS disease.Ten serum were identified (age at manifestation 18 months to 17 years). Eight antibody titers from ≥1:160 1:5,120 had complex diseases an age-dependent phenotype. Two structural epilepsy due malformations harbored nonspecific...
YY1 mutations cause Gabriele-de Vries syndrome, a recently described condition involving cognitive impairment, facial dysmorphism and intrauterine growth restriction. Movement disorders were reported in 5/10 cases of the original series, but no detailed description was provided. Here we present 21-year-old woman with mild intellectual deficit, complex movement disorder including an action tremor, cerebellar ataxia, dystonia, partial ocular apraxia as presenting most striking feature....
Background: Opsoclonus is a rare disorder characterized by conjugate multidirectional, horizontal, vertical, and torsional saccadic oscillations, without intersaccadic interval, resulting from dysfunction within complex neuronal pathways in the brainstem cerebellum. While most cases of opsoclonus are associated with autoimmune or paraneoplastic disorders, infectious agents, trauma, remain idiopathic, can also be caused medications affecting neurotransmission. This review was prompted case...
We report a patient with autonomic dysfunction following acute SARS-CoV-2 infection, presenting progressively worsening severe orthostatic hypotension to the point where she could no longer sit or stand. The experienced delay in diagnosis after an initial misdiagnosis of functional neurological disorder. Persistent symptoms prompted us re-examine and explore other diagnostic tools, which ultimately allowed identify treat immune-mediated (OH). identified autoantibodies (AAB) targeting nervous...
In 2024, therapeutic and diagnostic advancements are shaping the field of neurology. Three new drugs show promise for treating myasthenia gravis chronic inflammatory demyelinating polyneuropathy. A classification Parkinson's disease has been proposed, while a neuroprosthesis is improving gait in advanced stages. Revised criteria inclusion body myositis multiple sclerosis refining diagnoses, blood biomarkers enabling early detection Alzheimer's disease. The effectiveness thrombolysis stroke...
Germline mutations of YY1 cause Gabriele-de Vries syndrome (GADEVS), a neurodevelopmental disorder featuring intellectual disability and wide range systemic manifestations. To dissect the cellular molecular mechanisms underlying GADEVS, we combined large-scale imaging, single-cell multiomics gene regulatory network reconstruction in 2D 3D patient-derived physiopathologically relevant cell lineages. haploinsufficiency causes pervasive alteration type specific transcriptional networks,...
For several decades, deep brain stimulation has been a major breakthrough in the treatment of movement disorders, significantly improving quality life patients with Parkinson's disease, but also dystonia or tremor. Thanks to technological advances, this therapy continues evolve: directional electrodes, adaptive stimulation, and neural recordings allow for more precise targeting better clinical outcomes. At same time, epidural electrical opens up new perspectives, notably gait represents...
Synucleinopathies are frequently associated with non-motor symptoms such as orthostatic hypotension, which directly impacts patients' quality of life and requires effective management by general practitioners neurologists. This involves drug reconciliation, intensification lifestyle measures, and, in certain cases, the addition prohypertensive treatments. Emerging therapies promising for patients who do not respond to conservative management.
Parkinson's disease (PD) is a chronic illness characterized by multiple motor and non-motor symptoms that impact the quality of life patients their families. PD requires patient-centered therapeutic approach. Therapeutic patient education (TPE) an effective response to this challenge. TPE structured, person-centered learning process supports in self-monitoring self-management health drawing on own resources. It promotes behavior changes from moment diagnosis throughout course. Patients take...