Lateral lumbar interbody fusion (LLIF) is a useful minimally invasive technique for achieving anterior and preserving or restoring lordosis. However, circumferential via posterior instrumentation after an LLIF can be challenging, requiring either repositioning the patient placing pedicle screws in lateral position. Here, authors explore alternative single-position approach: prone (PL) position.A cadaveric feasibility study was performed using 2 human specimens. A retrospective 2-center early...

The recording radius and spatial selectivity of an extracellular probe are important for interpreting neurophysiological recordings but rarely measured. Moreover, analysis the biophysics multisite probes (e.g., tetrodes) can provide source characterization localization spiking single units, this capability has remained largely unexploited. Here we address both issues quantitatively. Advancing a tetrode (≈40-μm contact separation, tetrahedral geometry) in 5- to 10-μm steps, repeatedly...

Lateral lumbar interbody fusion (LLIF) facilitates the restoration of disc height and indirect decompression neural elements. However, these benefits are lost when graft subsides into adjacent endplates. The factors leading to subsidence after LLIF poorly understood. This article presents a case series patients who underwent reports correlating with subsidence.

Cadaveric surgical simulation carries the advantage of realistic anatomy and haptic feedback but has been historically difficult to model for intraventricular approaches given need active flow CSF. This feasibility study was designed simulate neuroendoscopic techniques by reconstituting natural CSF in a cadaveric model. In 10 fresh human cadavers, simple cervical laminectomy dural opening were made, 12-gauge arterial catheter introduced. Saline continuously perfused at physiological...

Gene regulatory interactions that shape developmental processes can often be inferred from microarray analysis of gene expression, but most computational methods used require extensive datasets difficult to generate. Here, we show maximum-entropy network allows extraction genetic limited datasets. Maximum-entropy networks indicated the inflammatory cytokine TNF-alpha plays a pivotal role in Schwann cell-axon interactions, and these data suggested TNF mediates its effects by orchestrating...

The challenges inherent in spinal oncology are multi-dimensional, stemming from the complex anatomy of spine, high risk neurological complications, and indispensability personalized treatment plans. These further compounded by variability tumor types locations, which complicates achievement optimal outcomes. To address these complexities, manuscript highlights pivotal role technological advancements surgical practices. review focuses on evolution instrumentation, with a special emphasis...

Sensory processing is an active process involving the interaction of ongoing cortical activity with incoming stimulus information. However, modulators and circuits involved in this are incompletely understood. One potential candidate cannabinoid-signaling system, which known to modulate dynamics networks. Here, we show that primate primary secondary visual cortices, cannabinoid CP55940 modulates not only population but also influences stimulus-response relationship individual neurons. At...

A full understanding of the computations performed in primary visual cortex is an important yet elusive goal. Receptive field models consisting cascades linear filters and static nonlinearities may be adequate to account for responses simple stimuli such as gratings random checkerboards, but their predictions complex natural scenes are only approximately correct. It unclear whether these discrepancies limited quantitative inaccuracies that reflect well-recognized mechanisms response...

Abstract Lateral lumbar interbody fusion (LLIF) is a widely used technique for anterior fusion. However, posterior decompression or instrumentation often requires repositioning the patient, which increases operative time. This video describes prone LLIF as modification of standard surgical technique. The facilitates simultaneous and fusion, avoids need increasing efficiency. Positioning, fluoroscopic considerations, nuances involved in performing position are described, an illustrative case...

Case-control study.Cervical spondylotic myelopathy (CSM) is the most common cause of spinal cord injury in adults aged over 55 years. However, since onset typically insidious, accurately diagnosing CSM can be challenging, often requiring referral to a subspecialist and advanced imaging. To help identify patients at risk for CSM, this case-control study compared responses series 4 questions (DOWN questionnaire) myelopathic non-myelopathic patients.Ninety-two patients, 46 with without...

Using drifting compound grating stimuli matched in energy and frequency spectrum, we previously showed that neurons the primary visual cortex (V1) were tuned to line-like, edge-like, intermediate one-dimensional features. Because these drifting, allowing for potential interaction between shape motion, examine here dependence of V1 feature tuning on drift speed. We find selectivity specificity individual strongly depend A simple model explains observations terms an linear filtering by...

Previous literature has described race and socioeconomic disparities in both treatment outcomes following cervical spinal cord injuries (SCI). The goal of this study is to investigate the current state parity management SCI. We surveyed National Inpatient Sample database (NIS) for patients admitted with primary diagnosis 49,320 were identified. Univariate multivariate analyses performed evaluate racial differences SCI care outcomes. Compared white patients, minority was associated a longer...

Single Photon Emission Computed Tomography/ Tomography (SPECT/CT) is an emerging imaging modality that identifies sites of heightened bone metabolism in response to increased stresses. The relationship between sacroiliac joint (SI) radiotracer uptake and anatomic biomechanical parameters poorly understood. Adult patients with SPECT/CT scans performed at our institution 2021-2023 for the workup low back pain were included. Patient charts reviewed demographic factors, including age, gender,...

Study Design Retrospective Cohort Study. Objective Single Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) is emerging as a valuable imaging test for identifying pain generators within the lumbar spine. The relationship between radiotracer uptake on SPECT/CT and anatomic biomechanical parameters has not been previously studied. Methods We performed retrospective review of all patients seen at our institution 2021-2023 who obtained scans workup thoracolumbar back pain....

Esthesioneuroblastomas (ENBs) are rare malignancies of the upper digestive tract, often demonstrating local metastasis to intracranial space through cribriform plate. These tumors show high rates recurrence locally following treatment. Here, we report a patient with advanced recurrent ENB 2 years initial treatment, affecting both spine and without evidence or contiguous extension from tumor site.A 32-year-old male presents month history neurological symptoms treatment Kadish C/AJCC stage IVB...

Deformity correction using minimally invasive surgical (MIS) techniques can be challenging. Here the authors present a case in which an anterior column resection was performed MIS lateral approach to restore lumbar lordosis and improve sagittal balance. The demonstrate technique discuss potential complications how they may avoided. video found here: https://youtu.be/XjOdDeKrKEE.