A5085333473- Neurological disorders and treatments
- Glioma Diagnosis and Treatment
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Cerebrospinal fluid and hydrocephalus
- Surgical Simulation and Training
- Lysosomal Storage Disorders Research
- Neurofibromatosis and Schwannoma Cases
- Spinal Dysraphism and Malformations
- Anatomy and Medical Technology
- Soft Robotics and Applications
- Parvovirus B19 Infection Studies
- Cardiac electrophysiology and arrhythmias
- Testicular diseases and treatments
- Trypanosoma species research and implications
- Augmented Reality Applications
- Pituitary Gland Disorders and Treatments
- Complex Systems and Time Series Analysis
- Echinoderm biology and ecology
- Fetal and Pediatric Neurological Disorders
- Nerve Injury and Rehabilitation
- Tree Root and Stability Studies
- Sports Dynamics and Biomechanics
- Ocular Oncology and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
Loma Linda University
2020-2024
Loma Linda University Medical Center
2020-2024
Cedars-Sinai Medical Center
2023
University of Southern California
2011-2022
Neurological Surgery
2011-2022
Children's Hospital of Los Angeles
2016-2018
Seattle Children's Hospital
2016
Southern California University for Professional Studies
2013
National Institutes of Health
2007
National Institute of Neurological Disorders and Stroke
2006
Recent preclinical studies have demonstrated that convection-enhanced delivery (CED) can be used to perfuse the brain and brainstem with therapeutic agents while simultaneously tracking their distribution using coinfusion of a surrogate magnetic resonance (MR) imaging tracer. The authors describe technique for successful clinical application this drug monitoring paradigm brainstem. Two patients progressive intrinsic lesions (one Type 2 Gaucher disease one diffuse pontine glioma) were treated...
We present fine mapping of a cis-acting nucleotide sequence found in the 5' region yellow fever virus genomic RNA that is required for replication. There evidence this interacts with complementary 3' genome to cyclize RNA. Replicons were constructed had various deletions encoding capsid protein and tested their ability replicate. 18 nucleotides (residues 146 163 genome, which encode amino acids 9 14 protein) essential replication replicon slightly longer 21 166, 15) full This larger than...
<b>Objective: </b> To determine if convection-enhanced delivery (CED) of glucocerebrosidase could be used to treat targeted sites disease progression in the brain and brainstem a patient with neuronopathic Gaucher while monitoring enzyme distribution using MRI. <b>Methods: A CED paradigm rodents (n = 8) primates 5) that employs co-infusion surrogate MRI tracer (gadolinium diethylenetriamine penta-acetic acid [Gd-DTPA]) permit real-time was developed. The safety feasibility this were...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFailure of the Eddy Diffusion Concept Gas Chromatography.J. C. Giddings and R. A. RobisonCite this: Anal. Chem. 1962, 34, 8, 885–890Publication Date (Print):July 1, 1962Publication History Published online1 May 2002Published inissue 1 July 1962https://pubs.acs.org/doi/10.1021/ac60188a005https://doi.org/10.1021/ac60188a005research-articleACS PublicationsRequest reuse permissionsArticle Views175Altmetric-Citations34LEARN ABOUT THESE METRICSArticle...
There is considerable evidence that several effects of catecholamines on beta receptors, including the positive inotropic effect heart, are mediated by cyclic-AMP.Myocardial cyclic-AMP concentration depends activity at least two enzymes: adenyl cyclase, regulating synthesis, and phosphodiesterase, degradation compound.In view importance adrenergic support in maintaining cardiac performance, we examined synthesis homogenates hearts from guinea pigs with congestive heart failure produced...
Tumor consistency plays an important and underrecognized role in the surgeon's ability to resect meningiomas, especially with evolving trends toward minimally invasive keyhole surgical approaches. Aside from descriptors such as "hard" or "soft," no objective criteria exist for grading, studying, conveying of meningiomas.The authors designed a practical 5-point scale intraoperative grading meningiomas based on internally debulk tumor subsequent resistance folding capsule. grades features are...
Abstract BACKGROUND Novel methodologies providing realistic simulation of the neurosurgical operating room environment are currently needed, particularly for highly subspecialized operations with steep learning curves, high-risk profiles, and demands advanced psychomotor skills. OBJECTIVE To describe development a curriculum using perfusion-based cadaveric models in “Mock Operating Room” procedures. METHODS At USC Keck School Medicine Fresh Tissue Dissection Laboratory between 2012 2016, 43...
Deep brain stimulation (DBS) for secondary (acquired, combined) dystonia does not reach the high degree of efficacy achieved in primary (genetic, isolated) dystonia. We hypothesize that this may be due to variability underlying injury, so different children require placement electrodes regions basal ganglia and thalamus. describe a new targeting procedure which temporary depth are placed at multiple possible targets thalamus, probing is performed using test recording while remain one week an...
// Winson S. Ho 1, * , Michael J. Feldman Dragan Maric 2 Lauren Amable 3 Matthew D. Hall 4 Gerald M. 5 Abhik Ray-Chaudhury 1 Martin Lizak 6 Juan-Carlos Vera 7 R. Aaron Robison 8 Zhengping Zhuang John Heiss Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, Institutes Health, Bethesda, MD 20892 NINDS Flow Cytometry Core Facility, on Minority Health Disparities, Center for Advancing Translational Sciences, Rockville, 20850, USA Drug Evaluation Research, Food...
Selection of targets for deep brain stimulation (DBS) has been based on clinical experience, but inconsistent and unpredictable outcomes have limited its use in patients with heterogeneous or rare disorders. In this large case series, a novel staged procedure neurophysiological assessment from 8 to 12 temporary depth electrodes is used select neuromodulation that are tailored each patient's functional needs. Thirty children young adults underwent target evaluation the new procedure:...
Cadaveric surgical simulation carries the advantage of realistic anatomy and haptic feedback but has been historically difficult to model for intraventricular approaches given need active flow CSF. This feasibility study was designed simulate neuroendoscopic techniques by reconstituting natural CSF in a cadaveric model. In 10 fresh human cadavers, simple cervical laminectomy dural opening were made, 12-gauge arterial catheter introduced. Saline continuously perfused at physiological...
Selective dorsal rhizotomy for spastic cerebral palsy is an effective and well-validated surgical approach. Multiple techniques have been described in the past including multiple laminectomies a single-level laminectomy at level of conus. There considerable technical challenge involved with approach.We report here modification that selectively analyzes each individual nerve root electromyography to separate ventral roots through comparison stimulus responses.In 18 children who underwent this...
Background: Deep brain stimulation for secondary dystonia has been limited by unknown optimal targets individual children. Objectives: We report the first case of a 7-year-old girl with severe generalized due to acquired striatal necrosis in whom we used new method identifying deep stimulation. Methods: implanted temporary depth electrodes 5 different nuclei bilaterally basal ganglia and thalamus, test recording during 1 week while child was an inpatient neuromodulation monitoring unit....
Objective: Chemoresistance is a widespread therapeutic challenge in glial tumors. The molecular basis of chemoresistance poorly understood, precluding advances glioma treatment and leaving gliomas among the most lethal Oligodendrogliomas provide unique model to study chemoresistance, as there are two distinct genetic subtypes with significant differences chemosensitivity. Despite high morphological similarity, tumors allelic loss on short arm chromosome 1 (1pLOH) more chemosensitive than...
<b><i>Background:</i></b> Children with ventriculoperitoneal shunts (VPS) undergoing brain computed tomography (CT) for shunt malfunction evaluation are at risk later malignancy due to radiation exposure. We aimed determine if and how hospitals have adopted radiation-avoiding magnetic resonance imaging (MRI) techniques. <b><i>Methods:</i></b> performed a secondary analysis of the Pediatric Health Information System (PHIS) database. VPS...
The contribution of different brain regions to movement abnormalities in children with dystonia is unknown. Three awake subjects undergoing depth electrode implantation for assessments potential deep recording targets performed a rhythmic figure-8 drawing task. Two had dystonia, one was testing treatment Tourette Syndrome and neither nor abnormal movements during testing. Movement-related signals were evaluated by determining the magnitude task-related frequency components. Brain recorded...
Background and Aims: Methionine adenosyltransferase alpha1 (MATα1) is responsible for the biosynthesis of S-adenosylmethionine in normal liver. Alcohol consumption enhances MATα1 interaction with peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1), which blocks mitochondrial targeting, resulting lower content dysfunction alcohol-associated liver disease (ALD) part through upregulation cytochrome P450 2E1. Conversely, alcohol intake SUMOylation, 2E1 expression. has potential...