A5012663710- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Meningioma and schwannoma management
- Intracranial Aneurysms: Treatment and Complications
- Scoliosis diagnosis and treatment
- Cerebrovascular and Carotid Artery Diseases
- Vascular Malformations Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Traumatic Brain Injury and Neurovascular Disturbances
- Pituitary Gland Disorders and Treatments
- Glioma Diagnosis and Treatment
- Pelvic and Acetabular Injuries
- Cerebrospinal fluid and hydrocephalus
- Cervical and Thoracic Myelopathy
- Moyamoya disease diagnosis and treatment
- Management of metastatic bone disease
- Surgical Simulation and Training
- Neurosurgical Procedures and Complications
- Acute Ischemic Stroke Management
- Aortic Disease and Treatment Approaches
- Trigeminal Neuralgia and Treatments
- Neurofibromatosis and Schwannoma Cases
- Hip and Femur Fractures
- Facial Nerve Paralysis Treatment and Research
- Spinal Cord Injury Research
Neurological Surgery
2015-2025
Mayo Clinic Hospital
2023-2025
Columbia University Irving Medical Center
2023-2024
NewYork–Presbyterian Hospital
2023-2024
University of Southern California
2015-2023
Rosalind Franklin University of Medicine and Science
2015-2023
LAC+USC Medical Center
2018-2023
Rush University Medical Center
2015-2023
John H. Stroger, Jr. Hospital of Cook County
2015-2023
University of California, Irvine
2017-2023
OBJECTIVE Cerebrospinal fluid (CSF) rhinorrhea is among the most common complications following transsphenoidal surgery for sellar region lesions. The aim of this study was to review authors' institutional experience in identifying, repairing, and treating CSF leaks associated with direct endonasal operations. METHODS authors performed a retrospective cases involving surgical treatment pituitary adenomas other lesions at University Southern California between December 1995 March 2016....
Immunization with an altered myelin-derived peptide (MOG45D) improves recovery from acute CNS insults, partially via recruitment of monocyte-derived macrophages that locally display a regulatory activity. Here, we investigated the local alterations in cellular and molecular immunological milieu associated attenuation Alzheimer's disease-like pathology following immunotherapy. We found immunization amyloid precursor protein/presenilin 1 double-transgenic mice MOG45D peptide, loaded on...
Background: The Spinal Cord Shape Classification System (SCSCS) class has been associated with spinal cord monitoring data loss during deformity surgery. objective of the current study was to prospectively validate SCSCS as a predictor Methods: A prospective cohort consecutive patients who were undergoing primary surgery at single institution from 2018 2023 and whose major curve in region undertaken. morphology apex on preoperative axial T2-weighted magnetic resonance imaging used categorize...
OBJECTIVE Mental disease burden can have a significant impact on levels of disability and health-related quality life (HRQOL) measures. Therefore, the authors investigated significance mental health status in adults with spinal deformity poor physical function. METHODS A retrospective analysis prospective multicenter database 365 adult (ASD) patients who had undergone surgical treatment was performed. Health-related QOL variables were examined preoperatively at 2-year postoperative...
ABCG2 (also known as breast cancer resistance protein) is an ATP-binding cassette (ABC) transporter localized to the plasma membrane where it mediates efflux of xenobiotics, including potential therapeutics. Studies investigating Abcg2 function at blood-brain barrier in mouse models are often compared with human function. It critical understand nature species differences between and ABCG2, since extrapolations made from murine data humans. Two independent drug-selected cell line pairs...
Abstract BACKGROUND Recent advancements have aimed to optimize visualization and minimize insult healthy cortical subcortical tissue through the use of tubular-based retractors. OBJECTIVE To investigate outcomes following resection cerebral metastases using an integrated tubular retraction system with exoscope neuronavigation. METHODS A multicenter retrospective analysis surgical in consecutive patients who underwent a brain metastasis was performed. RESULTS Twenty-five were included, mean...
Abstract BACKGROUND Novel methodologies providing realistic simulation of the neurosurgical operating room environment are currently needed, particularly for highly subspecialized operations with steep learning curves, high-risk profiles, and demands advanced psychomotor skills. OBJECTIVE To describe development a curriculum using perfusion-based cadaveric models in “Mock Operating Room” procedures. METHODS At USC Keck School Medicine Fresh Tissue Dissection Laboratory between 2012 2016, 43...
Atypical and anaplastic meningiomas have reduced progression-free/overall survival (PFS/OS) compared to benign meningiomas. Stereotactic radiosurgery (SRS) for atypical (AMs) (malignant meningiomas, MMs) has not been adequately described.To define clinical/radiographic outcomes patients undergoing SRS AM/MMs.An international, multicenter, retrospective cohort study was performed clinical/imaging receiving AM/MMs. Tumor progression assessed with response assessment in neuro-oncology (RANO)...
Significance The blood–brain barrier (BBB) prevents ingress of small molecules into the brain partly by expression drug efflux transporters. Although several transporters are known to be involved, role ABCG2 plays in this process is not clear. We demonstrate ability image function at BBB using luciferin a luciferase-expressing mouse. This represents direct measurement BBB, and demonstrates that does play functional BBB.
Surgical revascularization continues to play an important role in the management of complex intracranial aneurysms and ischemic cerebrovascular disease. Graft spasm is a common complication bypass procedures can result ischemia or graft thrombosis. The authors here report on first clinical use botulinum toxin prevent following extracranial-intracranial (EC-IC) bypass. This technique was used 3 EC-IC surgeries, 2 for symptomatic carotid artery occlusions 1 ruptured basilar tip aneurysm. In...
OBJECTIVE Patient demographic characteristics, hospital volume, and admission status have been shown to impact surgical outcomes of sellar region tumors in adults; however, the data available following resection craniopharyngiomas pediatric population remain limited. The authors sought identify potential risk factors associated with management craniopharyngiomas. METHODS Nationwide Inpatient Sample database Kids' Database were analyzed include admissions for patients (≤ 18 years) who...
OBJECTIVE Competency in endoscopic endonasal approaches (EEAs) to repair high-flow cerebrospinal fluid (CSF) leaks is an essential component of the neurosurgical training process. The objective this study was demonstrate feasibility a simulation model for EEA anterior skull base CSF leaks. METHODS Human cadaveric specimens were utilized with perfusion system simulate leak. Neurological surgery residents (postgraduate year 3 or greater) performed standard leak using combination fat, fascia...
OBJECTIVE Intraoperative contrast-enhanced ultrasound (iCEUS) offers dynamic imaging and provides functional data in real time. However, no standardized protocols or validated quantitative exist to guide its routine use neurosurgery. The authors aimed provide further clinical on the versatile application of iCEUS through a technical note illustrative case series. METHODS Five patients undergoing craniotomies for suspected tumors were included. was performed using contrast agent composed...
Objective To investigate risk factors for symptom recurrence in patients requiring a revision microvascular decompression (MVD) trigeminal neuralgia (TN) or hemifacial spasm (HFS). Design Retrospective review of prospectively maintained database. Participants Seventeen consecutive undergoing MVD at our institution between January 1993 and September 2017. Main Outcome Measures The incidence causes MVDs were recorded. Response to TN was tracked using the Barrow Neurological Institute (BNI)...
Abstract Background Treatment of vestibular schwannomas (VS) remains controversial. Historical surgical series prioritized gross total resections (GTR); however, near (NTR) and intentional subtotal (STR) aiming at improving cranial nerve outcomes are becoming more popular. Objective The main purpose this article is to assess the tumor control facial in VS patients treated with STR or NTR. Methods undergoing NTR our institution between 1984 2016 were retrospectively reviewed. Patient...