A5076847385- Cancer, Hypoxia, and Metabolism
- Neuropeptides and Animal Physiology
- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Cancer, Lipids, and Metabolism
- Systemic Lupus Erythematosus Research
- Ubiquitin and proteasome pathways
- Eicosanoids and Hypertension Pharmacology
- Peroxisome Proliferator-Activated Receptors
- Advanced Battery Technologies Research
- Amyotrophic Lateral Sclerosis Research
- Prenatal Screening and Diagnostics
- Lipid metabolism and biosynthesis
- Axon Guidance and Neuronal Signaling
- Immune Cell Function and Interaction
- Otitis Media and Relapsing Polychondritis
- Multilevel Inverters and Converters
- Congenital Anomalies and Fetal Surgery
- Chronic Myeloid Leukemia Treatments
- Advanced DC-DC Converters
- biodegradable polymer synthesis and properties
- Clinical Nutrition and Gastroenterology
- Nanoparticle-Based Drug Delivery
- Vasculitis and related conditions
Azienda Ospedaliero-Universitaria Cagliari
2024
University of Cagliari
2006-2024
Cedars-Sinai Medical Center
2016-2023
University of Michigan
2018
Marshall University
2017
Bidhan Chandra Krishi Viswavidyalaya
2017
Boston Children's Hospital
2017
Harvard University
2017
Regione Puglia
2003
University of Verona
2003
TAR deoxyribonucleic acid-binding protein 43 (TDP-43) is a key in the pathogenesis of amyoptrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Recent studies suggest that mutations TDP-43 coding gene, TARDBP, as well variations expression levels may disrupt dynamics stress granules (SGs). However, it remains unclear whether pathogenetic effect exerted at cytoplasmic level, through direct participation to SG composition, or nuclear control proteins essential...
Abstract Introduction: Breast cancer is the second most common among women, and excessive alcohol consumption a well-established risk factor for various cancers, including breast cancer. Even moderate (one drink per day) increases by 10% compared to non-drinking women. The STAR-related lipid transfer domain-containing protein 10 (StarD10), phosphoprotein, overexpressed in 35-40% of primary human cancers interacts with ErbB2 signalling pathway. Our recent studies demonstrated that ethanol...
// Maria Lauda Tomasi 1, * , Carla Cossu 2, Ylenia Spissu 2 Andrea Floris 3 Minjung Ryoo 1 Ainhoa Iglesias-Ara 4 Qiang Wang Stephen J. Pandol 7 Neil A. Bhowmick 5, 6, 8 Ekihiro Seki Edwin M. Posadas and Shelly C. Lu Division of Digestive Liver Diseases, Department Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA University Sassari, Italy Biomedical Science, Cagliari, Genetics, Faculty Science Technology, The Basque Country, Bilbao, Spain 5 Sciences, 6 Urologic Oncology...
Existing therapeutic strategies for breast cancer are limited by tumor recurrence and drug-resistance. Antioxidant plant-derived compounds such as flavonoids reduce adverse outcomes have been identified a potential source of antineoplastic agent with less undesirable side effects. Here, we describe the novel regulation fatty-acid synthase (FASN), key enzyme in de novo synthesis, whereby Vitis vinifera L. cv Vermentino leaf hydroalcoholic extract lowers its protein stability that is regulated...
The battery characterization and modelling of a Lithium-ion aimed at supporting the design energy storage system an All-Electric Aircraft (AEA) is presented. Specifically, developed model employed to evaluate power performance pack designed for AEA concept X- 57 Maxwell Mod.II. preliminary sizing performed referring project-flight mission-oriented air city taxing. evaluation targets satisfaction has been verified through simulation study based on proposed modelling. comparison between...
Alcohol acts through numerous pathways leading to alcoholic liver disease (ALD). Cytochrome P450 (CYP2E1), an ethanol-inducible enzyme, metabolizes ethanol-producing toxic reactive oxygen species (ROS) and is regulated at the posttranslational level. Small ubiquitin-like modifier (SUMO)ylation a modification that involves addition of SUMOs, which modulate protein stability, activity, localization. We demonstrated ubiquitin-conjugation enzyme 9, SUMO-conjugating induced in livers intragastric...
The present paper proposes an integrated method for modelling and designing Energy Storage Systems (ESSs) based on Sodium Metal Halide Batteries (SMHBs). implementation of the proposed methodology SMHB-ESS used supporting telecommunication DC microgrids is presented. motivation concerning this specific case study role assumed by battery technology in improving reliability robustness microgrids. In context, SMHBs, due to their operative temperature, dynamic power response against cell...
Ethanol abuse promotes breast cancer development, metastasis and recurrence stimulating mammary tumorigenesis by mechanisms that remain unclear. Normally, 35% of is Erb-B2 Receptor Tyrosine Kinase 2 (ERBB2)-positive predisposes to poor prognosis relapse, while ethanol drinking leads invasion their ERBB2 positive cells triggering the phosphorylation status mitogen-activated protein kinase. StAR-related lipid transfer 10 (STARD10) a transporter phosphatidylcholine (PC) phosphatidylethanolamine...
Background and Aims: Methionine adenosyltransferase alpha1 (MATα1) is responsible for the biosynthesis of S-adenosylmethionine in normal liver. Alcohol consumption enhances MATα1 interaction with peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1), which blocks mitochondrial targeting, resulting lower content dysfunction alcohol-associated liver disease (ALD) part through upregulation cytochrome P450 2E1. Conversely, alcohol intake SUMOylation, 2E1 expression. has potential...
Abstract Background: Existing therapeutic strategies for breast cancer are limited by tumor recurrence and drug-resistance. Several epidemiological studies indicate that antioxidant plant-derived compounds such as flavonoids reduce adverse outcomes have been identified a potential source of antineoplastic agent with less undesirable side effects. Activation lipid metabolism is an early event in carcinogenesis central hallmark cancer. In fact, inhibition fatty-acid synthesis results...
<h3>Background:</h3> Cognitive deficits (CDs) are frequent and worsen the quality of life Systemic Lupus Erythematosus (SLE) patients. The Montreal Assessment (MoCA) is a feasible test used to screen presence cognitive deficits. <h3>Objectives:</h3> aim study evaluate whether MoCA valid for identifying SLE patients who require targeted neuropsychological evaluation CDs discriminate which factors influence MoCA's alterations (including subjective symptomatology). <h3>Methods:</h3> A...
<h3>Background:</h3> Nowadays, numerous therapeutic options are available for patients with rheumatoid arthritis (RA), and the number of achieving remission has significantly increased. However, some have a disease defined by EULAR as "difficult-to-treat"<sup>1</sup> (D2T), which today represents new challenge rheumatologists. <h3>Objectives:</h3> The primary objective was to evaluate characteristics D2T-RA population recorded in Italian GISEA registry undergoing treatment b/tsDMARDs....
This paper deals with a battery-operated auxiliary DC/AC power conditioning system for all-electric aircraft, consisting of Triple Active Bridge coupled five-level cascaded H-bridge converter implemented Pulse Amplitude Width Modulation. The proposed has been developed an ultra-light electric aircraft and is characterized by 5kW output power, supplied at 115 V 400 Hz. synthesis the adopted control algorithm experimental validation on scaled-down prototype confirm worth solution design procedure.
<h3>Background</h3> Colour Doppler sonography (CDS) is an emerging diagnostic tool for giant cell arteritis (GCA), however, its use in routine practice still not widespread. <h3>Objectives</h3> To develop a protocol using CDS and explore value the care of patients with GCA. <h3>Methods</h3> We developed structured scanning temporal axillary arteries (total 8 anatomical sites scanned per patient) based on previously published methods. tested consecutive referred to single rheumatology centre,...
Stress granules (SGs) are transient cytoplasmic aggregates that rapidly form when cells exposed to stress and consist of large messenger ribonucleoprotein (mRNPs) complexes. The SGs seem function as storage depots for translation silenced complex implicated in stress-induced inhibition global protein synthesis. Protein aggregation, has been observed several neurodegenerative diseases, including Amyotrophic Lateral Sclerosis (ALS). TDP-43 (TAR DNA-Binding Protein-43), encoded by one the...
<h3>Background</h3> Interstitial lung disease (ILD) is very common in systemic sclerosis (SSc) and represents the leading cause of death. Despite its toxicity, cyclophosphamide (CYC) remains one most effective therapy. However, limited data about optimal dosage, duration therapy best way administration are available. It has been suggested that a prolonged CYC regimen might be more than shorter course. <h3>Objectives</h3> To evaluate safety response to oral long-term treatment with...