A5043842805- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Neurological disorders and treatments
- Neuroblastoma Research and Treatments
- Ear and Head Tumors
- Spine and Intervertebral Disc Pathology
- Meningioma and schwannoma management
- Lanthanide and Transition Metal Complexes
- Brain Metastases and Treatment
- Cerebrospinal fluid and hydrocephalus
- Advanced MRI Techniques and Applications
- Pituitary Gland Disorders and Treatments
- Acute Myeloid Leukemia Research
- Fibroblast Growth Factor Research
- Parkinson's Disease Mechanisms and Treatments
- Head and Neck Surgical Oncology
- Adrenal and Paraganglionic Tumors
- Spinal Dysraphism and Malformations
- Advanced Neuroimaging Techniques and Applications
- Sarcoma Diagnosis and Treatment
- Advanced Photonic Communication Systems
- Neurofibromatosis and Schwannoma Cases
- Ocular Oncology and Treatments
- Nerve injury and regeneration
- Intracranial Aneurysms: Treatment and Complications
The Ohio State University Wexner Medical Center
2016-2025
Neurological Surgery
2016-2025
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2015-2025
The Ohio State University
2012-2023
University of Southern California
2019
Nova Southeastern University
2019
University of Michigan
2019
University of Miami
2019
George Washington University
2006-2019
National Institutes of Health
2009-2018
Object. The goals of this study were to define the natural history and growth pattern hemangioblastomas central nervous system (CNS) that are associated with von Hippel—Lindau (VHL) disease correlate features development symptoms need for treatment. Methods. authors reviewed serial magnetic resonance images clinical histories 160 consecutive patients VHL who harbored CNS serially measured volumes tumors cysts. Six hundred fifty-five identified in cerebellum (250 tumors), brainstem (64...
Abstract Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare genetic disorder characterized by deficient synthesis of dopamine and serotonin. It presents in early infancy, causes severe developmental disability lifelong motor, behavioral, autonomic symptoms including oculogyric crises (OGC), sleep disorder, mood disturbance. We investigated the safety efficacy delivery viral vector expressing AADC (AAV2-hAADC) to midbrain children with (ClinicalTrials.gov Identifier NCT02852213)....
Object. Although recent studies have shown that convection can be used to distribute macromolecules within the central nervous system (CNS) in a homogeneous, targeted fashion over clinically significant volumes and volume of infusion target location (gray as opposed white matter) influence distribution, little is known about other factors may optimum use convection-enhanced distribution. To understand variables affect convective delivery more fully, we examined rate infusion, cannula size,...
The management of odontoid fractures remains controversial. Only direct anterior screw fixation provides immediate stabilization the spine and may preserve normal C1-2 motion. To determine indications, optimum timing, results for fractures, authors reviewed surgery-related outcome patients who underwent this procedure at two institutions.One hundred forty-seven consecutive (98 males 49 females) recent (< or = 6 months postinjury [129 patients]) remote (> 18 [18 Type II (138 cases) III (nine...
In the past, stereotactic surgical intervention for Parkinson's disease was considered indicated only in those patients with active motor manifestations that were refractory to pharmacological therapy, such as tremor, rigidity, dystonia, and dyskinesia. With reintroduction refinement of Leksell's posteroventral pallidotomy, both akinetic hyperkinetic symptoms are now amenable treatment. We have analyzed results 126 who underwent either unilateral (n = 58) or bilateral 68) pallidotomies. The...
Object. Von Hippel—Lindau (VHL) disease is an autosomal-dominant disorder frequently associated with hemangioblastomas of the spinal cord. Because slow progression, protean nature, and high frequency multiple VHL disease, surgical management these lesions complex. prior reports have not identified factors that predict which patients cord need surgery or what outcomes this procedure should be expected, authors reviewed a series who underwent resection at single institution to identify...
Hemangioblastomas of the brainstem constitute 5 to 10% central nervous system (CNS) tumors in patients with von Hippel-Lindau (VHL) disease. At present, optimal management hemangioblastomas associated VHL disease is incompletely defined. In an attempt clarify some uncertainty about operative treatment these lesions and its outcome, authors reviewed all cases which resection was performed at National Institutes Health during a 10-year period.Twelve consecutive (six male six female [mean age...
Direct interstitial infusion is a technique capable of delivering agents over both small and large dimensions brain tissue. However, at sufficiently high volumetric inflow rate, backflow along the catheter shaft may occur compromise delivery. A scaling relationship for finite distance this in pure gray matter (x(m)) has been determined from mathematical model based on Stokes flow, Darcy flow porous media, elastic deformation tissue: x(m) = constant Q(o)(3)R(4)r(c)(4)G(-3)mu(-1) 1/5...
Object In the course of their lives most patients with von Hippel–Lindau (VHL) disease require treatment for several symptom-producing hemangioblastomas cerebellum, brainstem, or spinal cord. However, many tumors never produce symptoms and do not treatment. Detection at an early stage lesions that will later ultimately would allow earlier excision cord, may identify cerebellar can be treated radiosurgery a before is contraindicated because tumor size presence associated cyst. Methods To...
Intrinsic disease processes of the brainstem (gliomas, neurodegenerative disease, and others) have remained difficult or impossible to treat effectively because limited drug penetration across blood-brainstem barrier with conventional delivery methods. The authors used convection-enhanced (CED) a macromolecular tracer visible on magnetic resonance (MR) imaging examine utility CED for safe perfusion brainstem.Three primates (Macaca mulatta) underwent various volumes infusion ([Vis]; 85, 110,...
Object The tumors most frequently associated with von Hippel-Lindau (VHL) disease are hemangioblastomas. While they significant neurological impairment and mortality, their natural history optimal management have not been fully defined. Methods Patients VHL were enrolled in a prospective study designed to define the of CNS In present analysis, serial imaging, laboratory, genetic, clinical data evaluated those at least 2 years follow-up data. Results At entrance 225 patients (111 males, 114...
A variety of mechanisms maintain the integrity genome in face cell stress. Cancer response to chemotherapeutic and radiation-induced DNA damage is mediated by multiple defense including polo-like kinase 1 (Plk-1), protein B (Akt-1), and/or p53 pathways leading either apoptosis or cycle arrest. Subsequently, a subpopulation arrested viable cancer cells may remain recur despite aggressive repetitive therapy. Here, we show that modulation (activation Akt-1 Plk-1 repression p53) these...
It is often difficult to find an adenoma in patients with Cushing's disease (CD) whose preoperative magnetic resonance imaging (MRI) normal. Better localizing modalities are needed.The aim of this study was determine the accuracy inferior petrosal sinus sampling (IPSS) predicting lateralization.We conducted a prospective observational at tertiary care clinical research center.A total 501 consecutive (363 female) confirmed ACTH adenomas and IPSS were included.We measured predict intrasellar...
Factors influencing the outcome of surgical treatment pediatric Cushing's disease (CD) have not been fully established. The aim this study was to examine features surgery for CD. In prospective observational study, clinical, imaging, endocrinological, and operative outcomes were analyzed in consecutive patients treated at National Institutes Health (NIH) from 1982 through 2010. conducted a tertiary referral center. Two hundred CD (106 females, 94 males) included. Mean age symptom development...
Object Despite the frequency of cerebellar hemangioblastomas in von Hippel–Lindau (VHL) disease, their optimum contemporary management has not been defined, and is made complex because multiple, progressive, protean nature tumors found patients with this disorder. To examine modern outcomes VHL authors reviewed findings disease who underwent resection hemangioblastomas. Methods Consecutive surgery for hemangioblastoma(s) at National Institutes Health were included. Eighty consecutive (44...
Clinical trials involving direct infusion of neurotrophic therapies for Parkinson's disease (PD) have suffered from poor coverage the putamen. The planned use a novel interventional-magnetic resonance imaging (iMRI) targeting system achieving precise, real-time convection-enhanced delivery in clinical trial adeno-associated virus serotype 2 (AAV2)-glial-derived factor (GDNF) PD patients was modeled nonhuman primates (NHP). NHP received bilateral coinfusions gadoteridol (Gd)/AAV2-GDNF into...
The astrocytic contribution to the blood-brain barrier (BBB) in metastatic and primary malignant brain tumors is not well understood. To better understand vascular properties associated with tumors, authors systematically analyzed component of BBB neoplasms.Twelve patients who underwent resection or neoplasms (4 lesions, 2 low-grade astrocytomas, anaplastic 4 glioblastoma multiforme) were included. Clinical, MRI, operative, histopathological immunohistochemical (glial fibrillary acidic...