A5101908033- Complement system in diseases
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Renal and related cancers
- Acute Kidney Injury Research
- Monoclonal and Polyclonal Antibodies Research
- Reproductive System and Pregnancy
- Psoriasis: Treatment and Pathogenesis
- Immunotherapy and Immune Responses
- Research on Leishmaniasis Studies
- Immune Response and Inflammation
- Toxin Mechanisms and Immunotoxins
- Chemotherapy-induced organ toxicity mitigation
- Dermatology and Skin Diseases
- Phagocytosis and Immune Regulation
- NF-κB Signaling Pathways
- Drug Transport and Resistance Mechanisms
- Biomedical Research and Pathophysiology
- Chronic Kidney Disease and Diabetes
- Reproductive tract infections research
- Urticaria and Related Conditions
- Glycosylation and Glycoproteins Research
- IL-33, ST2, and ILC Pathways
- Sphingolipid Metabolism and Signaling
- Connexins and lens biology
Army Medical University
2013-2025
Guiyang Medical University
2025
State Council of the People's Republic of China
2019-2020
Southwest Hospital
2019-2020
Huanggang Normal University
2019
University of Florida Health
2012
University of Manitoba
2007
Abstract Renal fibrosis is the final manifestation of various chronic kidney diseases, and no effective therapy available to prevent or reverse it. Celastrol, a triterpene that derived from traditional Chinese medicine, known potent anti-fibrotic agent. However, underlying mechanisms action celastrol on renal remain unknown. In this study, we found treatment remarkably attenuated unilateral ureteral obstruction (UUO)-induced mouse fibrosis. This was evidenced by significant reduction in...
Di (2-ethylhexyl) phthalate (DEHP) is an acknowledged endocrine disruptor with male reproductive toxicity; nevertheless, the transgenerational impacts on offspring resulting from paternal exposure, along mechanisms involved, are not well understood. To develop a model of DEHP C57BL/6J mice (4-week) exposed to (5, 250, and 500 mg/kg/d) for 35 days were then bred unexposed female at ratio 1:2 produce offspring. Findings indicate that sperm quality relative sex hormones adversely affected in...
Heat-shock is an acute insult to the mammalian proteome.The sudden elevation in temperature has far-reaching effects on protein metabolism, leads a rapid inhibition of most synthesis, and induction chaperones.Using heat-shock cells neuronal (SH-SY5Y) glial (CCF-STTG1) lineage, conjunction with detergent extraction sedimentation followed by LC-MS/MS proteomic approaches, we sought identify human proteins that lose solubility upon heat-shock.The two cell lines showed largely overlapping...
Tumor necrosis factor (TNF)-α and interferon (IFN)-γ are the major pro-inflammatory cytokines involved in beta-cell destruction. The fate of islet beta-cells cytokine-induced intrinsic mitochondrial apoptotic pathway is determined by interaction between members Bcl-2 family. However, mechanism through which apoptosis regulated remains unclear. In this study, we treated murine line NIT-1 with TNF-α IFN-γ then investigated regulation signal transducer activator transcription-1 (STAT-1)...
Abstract Sepsis‐associated acute kidney injury (SA‐AKI) is a common clinical critical care syndrome. It has received increasing attention due to its high morbidity and mortality; however, pathophysiological mechanisms remain elusive. LIGHT, the 14th member of tumour necrosis factor (TNF) superfamily bidirectional immunoregulatory molecule that regulates inflammation, plays pivotal role in disease pathogenesis. In this study, mice with an intraperitoneal injection LPS HK‐2 cells challenged...
Abstract Although studies indicate LIGHT (lymphotoxin (LT)-like, exhibits inducible expression and competes with HSV glycoprotein D for herpes virus entry mediator (HVEM), a receptor expressed by T lymphocytes) enhances inflammation cell-mediated immunity, the mechanisms involved in this process remain obscure. In study, we assessed role of IL-12 production development CD4+ Th cells type one (Th1) vivo. Bone marrow-derived dendritic from LIGHT−/− mice were severely impaired IL-12p40...
Fulminant hepatic failure (FHF) is a clinically severe type of liver injury with an extremely high mortality rate. Although the pathological mechanisms FHF are not well understood, evidence suggests that complement system involved in pathogenesis variety disorders. In present study, to investigate role FHF, we examined groups mice following intraperitoneal injection LPS/D-GalN: wild-type C57BL/6 mice, treated C3aR antagonist, C5aR monoclonal antibody (C5aRmAb) or CR2-Factor H (CR2-fH,...
Psoriasis is one of the most common chronic inflammatory skin diseases, affecting approximately 2% population. The lack characterization pathogenesis psoriasis has hindered efficient clinical treatment disease. In our study, we observed that expression complement component 5a receptor 1(C5aR1) was significantly increased in lesions both imiquimod (IMQ) and IL23-induced psoriatic mice patients with psoriasis. C5aR1 deficiency or C5a antagonist (C5aRa) attenuated psoriasis-like cytokines...
Abstract LIGHT recruits and activates naive T cells in the islets at onset of diabetes. IFN ‐γ secreted by activated lymphocytes is involved beta cell apoptosis. However, whether sensitizes γ‐induced destruction remains unclear. In this study, we used murine line MIN 6 primary islet as models for investigating underlying cellular mechanisms / γ – induced pancreatic destruction. synergistically reduced viability; decreased viability was due to apoptosis, demonstrated a significant increase...
Fibrinogen-like protein 2 (FGL2) is highly expressed in various tumour tissues and plays a vital role initiation progression. This study evaluated the clinical significance of FGL2 patients with clear cell renal carcinoma (ccRCC). expression fresh 170 archived paraffin-embedded ccRCC was measured by quantitative RT-PCR, western blotting, immunohistochemitry. significantly upregulated ccRCC. Statistical analyses using Kaplan-Meier method showed that high associated poor overall survival (OS)...
Tumor necrosis factor superfamily protein 14 (TNFSF14) was recently identified as a risk in some fibrosis diseases. However, the role of TNFSF14 renal pathogenesis remains unknown.It found that levels were significantly increased both UUO-induced fibrotic mice and patients with nephropathy, compared those controls. Accordingly, Tnfsf14 deficiency led to marked reduction lesions inflammatory cytokines expression UUO mice. Furthermore, Sphk1, critical molecule causes remarkably reduced KO...
Abstract The protective immunity induced by the whole-killed parasite vaccine against malarial blood-stage infection is dependent on CD4+ T cell response. However, mechanism underlying this robust response elicited still largely unknown. In study, we observe that immunization with Plasmodium yoelii–parasitized RBC lysate activates complement C5 and generates C5a. efficacy P. yoelii 17XL challenge considerably reduced, malaria-specific activation memory differentiation are suppressed in...
Ischemia-reperfusion (I/R), a leading risk factor of acute kidney injury (AKI), is associated with high mortality and progression to chronic disease. However, the molecular mechanism I/R-AKI remains not fully understood, which hinders its efficient clinical treatment. In this study, we observed that LIGHT deficiency remarkably attenuated I/R-AKI, as evidenced by rescued renal function, ameliorated tubular cell apoptosis, alleviated inflammatory responses. Consistently, blocking signaling...
Emerging evidence has shown activation of the complement component C5 to C5a in cancer tissues and C5aR expression breast cells relates tumor development poor prognosis, suggesting involvement C5a/C5aR pathway pathogenesis. In this study, we found that as compared non-tumoral tissues, both MAPK/p38 showed an elevated expression, but p21/p-p21 lower tumoral patients. Mice deficient or mice treated with antagonist exhibited attenuation growth reduction p38/p-p38 increase tissues. Pre-treatment...
Breast cancer is the most diagnosed malignancy and major cause of death among women population in worldwide. Ferroptosis a recently discovered iron-dependent regulated cell involved tumor progression therapeutic response. Moreover, increasing studies have implied that ferroptosis promising approach to eliminating cells like developing iron nanoparticles as agent. However, resistance vital distinctive hallmark cancer. Therefore, further investigation mechanism enhance its sensitivity...
Abstract We previously showed that LIGHT and its receptor herpes virus entry mediator (HVEM) are important for development of optimal CD4+ Th1 cell immunity resistance to primary Leishmania major infection in mice. In this study, we further characterized the contributions molecule dendritic (DC) maturation, initiation, maintenance secondary anti-Leishmania immunity. Flow-cytometric studies CD8α+ DC subset was mostly affected by HVEM-Ig lymphotoxin β receptor-Ig treatment. signaling is...
Psoriasis is a chronic relapsing inflammatory skin disease, affecting up to 3% of the global population. Accumulating evidence suggests that complement system involved in its pathogenesis. Our previous study revealed C5a/C5aR1 pathway crucial for disease development. However, underlying mechanisms remain largely unknown. To explore potential mechanisms, psoriatic lesions and histological changes were assessed following imiquimod (IMQ) cream treatment. Inflammatory cytokine expression was...