Background: Over the last few decades, annual global incidence of gastroenteropancreatic neuroendocrine tumours (GEP-NETs) has steadily increased. Because complex and inconsistent treatment GEP-NETs, prognosis patients with GEP-NETs is still difficult to assess. The study aimed construct validate nomograms included data for prediction overall survival (OS) in patients. Methods: determined from Surveillance, Epidemiology, End Results (SEER)-13 registry database (1992–2018) additional SEER-18...

Objectives To explore the value of cellular microstructural mapping by IMPULSED (imaging parameters using limited spectrally edited diffusion) method in evaluating histological type and prognostic factors rectal lesions. Materials methods Sixty-six patients with lesions were enrolled this study. All subjects underwent MRI scans including conventional diffusion weighted imaging (DWI) oscillating gradient spin-echo (OGSE) pulse (PGSE) sequences. Parameters mean cell diameter (d ),...

This study aims to investigate the feasibility of cellular microstructural mapping by diffusion MRI (IMPULSED, imaging parameters using limited spectrally edited diffusion) breast tumors, and further evaluate whether MRI-derived features is associated with prognostic factors in cancer. prospective collected 232 patients suspected tumors from March August 2023. The IMPULSED scan included acquisitions both pulsed (PGSE) oscillating (OGSE) gradient spin echo frequencies up 33 Hz. OGSE PGSE data...

Systemic sclerosis is a rare autoimmune disorder that affects multiple organ systems, including the lungs, kidneys, and liver, often leads to fatal complications. Adrenocortical adenoma, benign tumor, can secrete hormones such as cortisol, resulting in symptoms hypertension, diabetes, obesity, although it also be asymptomatic. This article presents case of patient with systemic adrenocortical detailing diagnostic therapeutic journey before after laparoscopic adrenal tumor resection. It...

Lung adenocarcinoma is the most common type of lung cancer and one lethal prevalent cancers. Aberrant glycosylation was essential in tumorigenesis, with fucosylation as types disrupted However, it still unknown whether genes involved are important for development process.GMDS cellular fucosylation. Here we examined GMDS expression level at both mRNA protein adenocarcinoma. The impact knockdown on vitro vivo investigated. Transcriptome changes cells were also to provide insights into related...

Silibinin, a major polyphenol in milk thistle, has been reported to have multiple pharmacological activities; therefore, there is an urgent need well understand how silibinin works on inflammation-associated skin diseases. We herein designed 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated inflammation test its inhibitory effects. It was demonstrated that silibinin, applied topically onto mouse ears following TPA stimulation, effectively down-regulated the expressions of TPA-induced...

Decompression sickness is a systemic pathophysiological process caused by bubbles and endothelial microparticles (EMPs) are established markers reflecting competency of function vascular biology. Here, we investigated the effects bubble-induced EMPs on cells in vitro vivo. Rat pulmonary microvascular (PMVECs) were isolated stimulated collected incubated with normal PMVECs vitro. Cell viability apoptosis detected using Counting Kit-8 assay Annexin V FITC/PI double staining, respectively....

Objective Papillary renal cell carcinoma (pRCC) is the second most common type of and an important disease affecting older patients. We aimed to establish a nomogram predict cancer-specific survival (CSS) in elderly patients with pRCC. Methods Patient information was downloaded from Surveillance, Epidemiology, End Results (SEER) project, we included all pRCC 2004 2018. All were randomly divided into training cohort validation cohort. Univariate multivariate Cox proportional risk regression...

Fibrinogen-like protein 2 (FGL2) is highly expressed in various tumour tissues and plays a vital role initiation progression. This study evaluated the clinical significance of FGL2 patients with clear cell renal carcinoma (ccRCC). expression fresh 170 archived paraffin-embedded ccRCC was measured by quantitative RT-PCR, western blotting, immunohistochemitry. significantly upregulated ccRCC. Statistical analyses using Kaplan-Meier method showed that high associated poor overall survival (OS)...

Background Routine screening of prostate specific antigen (PSA) is no longer recommended because a high rate over-diagnosis cancer (PCa). Objective To evaluate the efficacy diffusion-weighted magnetic resonance imaging (DW-MRI) for PCa detection, and to explore clinical utility ultrahigh b-value DW-MRI in predicting biopsy outcomes. Methodology 73 male patients were selected study. They underwent 3T MRI using T2WI conventional with 1000 s/mm2, b-values 2000 s/mm2 3000 s/mm2. Two radiologists...

Inflammatory reaction is the crux in various clinical critical diseases including decompression sickness (DCS). Ulinastatin (UTI), a potent anti-inflammatory agent, has been used clinically, as substitution for steroids. This study aimed to explore potential effects of UTI upon DCS rabbit model. Eighty-eight rabbits were subjected simulated diving 6 atmospheres absolute (ATA) 60 min with 2.5-min decompression. Three doses (15/7.5/3.75×105 U/kg) or saline intravenously administered...

Abstract Background CM082 is a novel angiogenesis inhibitor targeting vascular endothelial growth factor receptor (VEGFR) and platelet‐derived (PDGFR). The purpose of this research was to evaluate the antitumor activity combined with gefitinib on epidermal (EGFR) mutant non‐small cell lung cancer (NSCLC) in vitro vivo. Methods effect human umbilical vein cells (HUVECs) assessed. In vivo efficacy EGFR NSCLC lines (HCC827 harboring E746_A750 deletion H3255 L858R) xenograft model evaluated....

Abstract Heterotopic brain tissue is rare and has not been reported. Our center made the first report. 4 years 2 months old Girl presented with a cystic mass in right adrenal gland weeks after upper abdominal pain. The operation was successful, diagnosis confirmed by postoperative pathology. 6 procedure, incision healed well without recurrence. This case report detailed treatment process satisfactory examination results. It can provide reference for diagnosing treating clinical HBT reduce...

The aim of this study is to explore clinical efficacy crizotinib in advanced anaplastic lymphoma kinase (ALK) positive non-small cell lung cancer.patients with cancer habouring ALK were randomly divided into group (n=14) and chemotherapy (n=14). Patients the receive oral treatment (250 mg) twice daily. administrated docetaxel injection (75 mg/m2) every three weeks patient was treated at least 3 period. Then observed after 12 mo followed-up.Effective rate patients 64.29%. It significantly...

To dynamically monitor the changes of genomic characteristics during lorlatinib treatment and analyze resistance profile in ALK-positive advanced Chinese patients with non-small cell lung cancer (NSCLC) first- second-generation ALK inhibitor resistance.Ten eligible who were from a phase 2 study China admitted to Fifth Medical Center PLA General Hospital analyzed. Blood samples collected for next-generation sequencing (NGS) characterize genetic variation at baseline, treatment, after disease...

Giant fibroepithelial polyp (FP) of the scrotum in infants is a rare disease. We reported first case FP China. The child was only 9 months and 12 days old admitted to hospital due rapid growth rupture scrotal mass. patient underwent exploration under general anesthesia, mass cystic-solid with clear boundaries. tumor did not invade sarcolemma testicular tissue. intraoperative pathological frozen section tended be benign, scrotum's subcutaneous pedicle tissue were removed entirely after 0.5 cm...

Abstract Background The efficacy difference between the second‐ and third‐generation of anaplastic lymphoma kinase‐tyrosine kinase inhibitors (ALK‐TKIs) after crizotinib failure in advanced ALK ‐positive non–small cell lung cancer (NSCLC) has not been clarified. This study evaluates different sequential patterns progression. Methods Data patients who met criteria were retrospectively analyzed. Kaplan–Meier method was used to draw survival curves, log‐rank compare differences groups, Cox...

Purpose To investigate the effect of sub-satisfactory stent recanalization on hemodynamic stresses for severe stenoses middle cerebral artery (MCA) M 1 segment. Materials and methods Patients with MCA M1 segment treated endovascular angioplasty were retrospectively enrolled. Three-dimensional digital subtraction angiography before after stenting was performed; computational fluid dynamics (CFD) analysis at stenosis normal segments proximal distal to analyzed. Results Fifty-one patients...