Timothy Keyes

ORCID: 0000-0003-0423-9679
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About
Contact & Profiles
Research Areas
  • Single-cell and spatial transcriptomics
  • Diversity and Career in Medicine
  • Social Media in Health Education
  • Cancer Genomics and Diagnostics
  • LGBTQ Health, Identity, and Policy
  • Health Literacy and Information Accessibility
  • Cell Image Analysis Techniques
  • AI in cancer detection
  • Cerebrospinal fluid and hydrocephalus
  • Neonatal Respiratory Health Research
  • Bioinformatics and Genomic Networks
  • Gene Regulatory Network Analysis
  • Medical Education and Admissions
  • Immune Cell Function and Interaction
  • Digital Imaging for Blood Diseases
  • Advanced Fluorescence Microscopy Techniques
  • Economic and Financial Impacts of Cancer
  • Barrier Structure and Function Studies
  • Sexuality, Behavior, and Technology
  • Advanced Biosensing Techniques and Applications
  • Advanced X-ray and CT Imaging
  • Planarian Biology and Electrostimulation
  • Inflammasome and immune disorders
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Advanced Semiconductor Detectors and Materials

RAND Corporation
2025

Stanford University
2018-2024

American Physician Scientists Association
2024

Palo Alto University
2023

Stanford Medicine
2023

ORCID
2018

Georgia Department of Natural Resources
2017

University of Virginia
2015

The traditional model of promotion and tenure in the health professions relies heavily on formal scholarship through teaching, research, service. Institutions consider how much weight to give activities each these areas determine a threshold for advancement. With emergence social media, scholars can engage wider audiences creative ways have broader impact. Conventional metrics like h-index do not account media Social engagement is poorly represented most curricula vitae (CV) therefore...

10.2196/25070 article EN cc-by Journal of Medical Internet Research 2020-12-02

Background: Use of complementary and integrative health care (CIH) varies across racial ethnic groups in the United States. Lack diversity among CIH providers may hinder access to for underrepresented groups. This study aimed (1) document representation licensed professions (chiropractic, acupuncture, traditional East Asian medicine, naturopathic direct-entry midwifery, massage therapy), non-licensed professions, conventional care; (2) compare these with U.S. population; (3) examine changes...

10.1089/jicm.2024.0745 article EN Journal of Integrative and Complementary Medicine 2025-02-21

Abstract The increasing use of mass cytometry for analyzing clinical samples offers the possibility to perform comparative analyses across public datasets. However, challenges in batch normalization and data integration limit comparison datasets not intended be analyzed together. Here, we present a strategy, CytofIn, using generalized anchors integrate from domain. We show that low-variance controls, such as healthy stable channels, are inherently homogeneous, robust against stimulation, can...

10.1038/s41467-022-28484-5 article EN cc-by Nature Communications 2022-02-17

Many health professions faculty members lack training on fundamental lesbian, gay, bisexual, transgender, and queer (LGBTQ+) topics. Faculty development is needed to address knowledge gaps, improve teaching, prepare students competently care for the growing LGBTQ+ population.We conducted a program evaluation of massive open online course Teaching Health: A Development Course Health Professions Educators from Stanford School Medicine. Our goal was understand participant demographics, impact,...

10.2196/47777 article EN cc-by JMIR Medical Education 2023-06-12

While many algorithms for analyzing high-dimensional cytometry data have now been developed, the software implementations of these remain highly customized-this means that exploring a dataset requires users to learn unique, often poorly interoperable package syntaxes each step processing. To solve this problem, we developed {tidytof}, an open-source R using increasingly popular 'tidy data' interface.{tidytof} is available at https://github.com/keyes-timothy/tidytof and released under MIT...

10.1093/bioadv/vbad071 article EN cc-by Bioinformatics Advances 2023-01-01

The 2014 NIH Physician-Scientist Workforce Working Group predicted a future shortage of physician-scientists. Subsequent studies have highlighted disparities in MD-PhD admissions based on race, income, and education. Our analysis data from the Association American Medical Colleges covering 2014-2021 (15,156 applicants 6,840 acceptees) revealed that acceptance into US programs correlates with research experience, family publications. number experiences associated parental education income....

10.1172/jci.insight.176146 article EN cc-by JCI Insight 2024-02-08

ABSTRACT Red knots ( Calidris canutus rufa ) have 3 distinct nonbreeding regions: 1 in the southeastern United States and Caribbean, another on northeast coast of Brazil Maranhão region, a third along Patagonian coasts Chile Argentina. Effective conservation recovery this threatened long‐distance migrant will require knowledge population structure, migration ecology, abundance distribution throughout annual cycle. We conducted stopover biogeographic assessment at Altamaha River Delta,...

10.1002/jwmg.21389 article EN Journal of Wildlife Management 2017-10-23

Abstract Transcription factors (TFs) and transcriptional coregulators represent an emerging class of therapeutic targets in oncology. Gene regulatory networks (GRNs) can be used to evaluate pharmacological agents targeting these identify drivers disease drug resistance. However, GRN methods that rely solely on gene expression often fail account for post-transcriptional modulation TF function. We present Epiregulon, a method constructs GRNs from single-cell ATAC-seq RNA-seq data accurate...

10.1101/2023.11.27.568955 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2023-11-28

In the United States, approximately one in 1000 children are diagnosed with autoinflammatory disease, Juvenile Idiopathic Arthritis (JIA). A subset of JIA cases manifests as Systemic (sJIA), which is characterized by joint pain, fevers, rashes, and systemic inflammation. Severe pulmonary complications have not historically been associated sJIA. Since 2010, inhibitors interleukin-1 interleukin 6 (IL-1i/IL-6i) recommended course treatment for sJIA, yet recently studies show evidence a severe...

10.1101/2024.11.22.624756 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2024-11-23

ABSTRACTABSTRACTLesbian, gay, bisexual, transgender, queer, intersex, asexual, non-binary, two-spirit, and other (LGBTQ+) students are a diverse group with unique frequently overlooked needs in medical training. The present study was designed to understand the concerns of LGBTQ+ applicants school examine effectiveness webinar alleviating concerns. Sixty participants joined webinars discussing application process particular attention pertinent population. Pre post surveys were administered...

10.1080/00918369.2022.2160942 article EN Journal of Homosexuality 2023-01-10

National affinity organisations for medical students from groups that are under-represented in medicine, such as the Asian Pacific American Medical Student Association, Latino Association and have significant impact on promoting diversity inclusion within physician workforce pipeline.1 However, no national organisation exists lesbian, gay, bisexual, transgender queer (LGBTQ+) students, despite fact many schools local organisations. This lack of a communication resource network has limited...

10.1111/medu.14112 article EN Medical Education 2020-04-03

<sec> <title>BACKGROUND</title> Many health professions faculty members lack training on fundamental lesbian, gay, bisexual, transgender, and queer (LGBTQ+) topics. Faculty development is needed to address knowledge gaps, improve teaching, prepare students competently care for the growing LGBTQ+ population. </sec> <title>OBJECTIVE</title> We conducted a program evaluation of massive open online course &lt;i&gt;Teaching Health: A Development Course Health Professions Educators&lt;/i&gt; from...

10.2196/preprints.47777 preprint EN 2023-03-31

Abstract Single-cell multiomic technologies enable holistic reconstruction of cell states and hold the potential to identify drivers tumor evolution drug resistance. However, data sparsity single-cell assays can preclude accurate estimation transcription factor activity. In addition, gene expression alone cannot capture activity, especially in context treatment which alters function without suppressing expression. To circumvent these challenges, we have developed epiregulon, a R package that...

10.1158/1538-7445.am2023-3141 article EN Cancer Research 2023-04-04
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