A5069291112- Tuberculosis Research and Epidemiology
- Infectious Diseases and Tuberculosis
- Complement system in diseases
- Mycobacterium research and diagnosis
- Malaria Research and Control
- Ferroptosis and cancer prognosis
- Inflammasome and immune disorders
- Organic Electronics and Photovoltaics
- Virus-based gene therapy research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sarcoidosis and Beryllium Toxicity Research
- Conducting polymers and applications
- Cancer Immunotherapy and Biomarkers
- Diagnosis and treatment of tuberculosis
- Photochromic and Fluorescence Chemistry
- Viral Infections and Outbreaks Research
- Immune Cell Function and Interaction
- Immune cells in cancer
- Respiratory viral infections research
- HIV Research and Treatment
- Neonatal Respiratory Health Research
- Cell Image Analysis Techniques
Stanford University
2020-2025
Abstract Immune checkpoint inhibition (ICI) has fundamentally changed cancer treatment. However, only a minority of patients with metastatic triple negative breast (TNBC) benefit from ICI, and the determinants response remain largely unknown. To better understand factors influencing patient outcome, we assembled longitudinal cohort tissue multiple timepoints, including primary tumor, pre-treatment on-treatment tumor 117 treated ICI (nivolumab) in phase II TONIC trial. We used highly...
SUMMARY Despite being heavily infiltrated by immune cells, tuberculosis (TB) granulomas often subvert the host response to Mycobacterium (Mtb) infection and support bacterial persistence. We previously discovered that human TB are enriched for immunosuppressive factors typically associated with tumor-immune evasion, raising intriguing possibility they promote tolerance infection. In this study, our goal was identify prime drivers establishing tolerogenic niche determine if magnitude of...
Abstract Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis that distinctly characterized granuloma formation within infected tissues. Granulomas are dynamic and organized immune cell aggregates limit dissemination, but can also hinder bacterial clearance. Consequently, outcome in TB influenced how structure composition shift the balance between these two functions. To date, our understanding of what factors drive function humans limited. With this mind, we used...
Non-human primate (NHP) animal models are an integral part of the drug research and development process. For some biothreat pathogens, model challenge studies may offer only possibility to evaluate medical countermeasure efficacy. A thorough understanding host immune responses in such NHP is therefore vital. However, applying antibody-based characterization techniques requires extensive reagent for species compatibility. In case involving high consequence further optimization use inactivated...
Solar thermal batteries allow for on-demand heat release of stored chemical energy. Azobenzene (AB) is a photoactive molecule particular interest storage applications due to its ability absorb ultraviolet light, isomerize the cis isomer, and upon discharging trans isomer. In functioning device, AB requires substrate matrix not only stabilize "charged" state but also provide enough free volume charging discharging. this work, we integrate multiwalled carbon nanotubes (MWCNTs) with carboxylic...
In the United States, approximately one in 1000 children are diagnosed with autoinflammatory disease, Juvenile Idiopathic Arthritis (JIA). A subset of JIA cases manifests as Systemic (sJIA), which is characterized by joint pain, fevers, rashes, and systemic inflammation. Severe pulmonary complications have not historically been associated sJIA. Since 2010, inhibitors interleukin-1 interleukin 6 (IL-1i/IL-6i) recommended course treatment for sJIA, yet recently studies show evidence a severe...
Background: Malaria in pregnancy causes higher morbidity primigravid women compared to multigravid; however, the correlates and mechanisms underlying this gravidity-dependent protection against remain incompletely understood.Methods: We characterized cellular immune response during second trimester of pregnant (n=203) living eastern Uganda, a highly malaria-endemic region, combining RNA sequencing, multiparameter flow cytometry, functional assays. responses between multigravid assessed...