A5066880171- Single-cell and spatial transcriptomics
- Cell Image Analysis Techniques
- Global Political and Social Dynamics
- European history and politics
- Global Peace and Security Dynamics
- Image Processing Techniques and Applications
- Immune cells in cancer
- Social Policy and Reform Studies
- African history and culture studies
- International Development and Aid
- Tuberculosis Research and Epidemiology
- Religion and Sociopolitical Dynamics in Nigeria
- Infectious Diseases and Tuberculosis
- World Systems and Global Transformations
- Political Conflict and Governance
- AI in cancer detection
- Economic Growth and Development
- Historical and Contemporary Political Dynamics
- T-cell and B-cell Immunology
- Advanced biosensing and bioanalysis techniques
- German legal, social, and political studies
- International Relations and Foreign Policy
- Chemokine receptors and signaling
- African Studies and Geopolitics
- African Sexualities and LGBTQ+ Issues
California Institute of Technology
2018-2024
Yale University
2014
Naval Medical Center Portsmouth
2011
University of Guelph
1981-1997
Image-based spatial transcriptomics methods enable transcriptome-scale gene expression measurements with information but require complex, manually tuned analysis pipelines. We present Polaris, an pipeline for image-based that combines deep-learning models cell segmentation and spot detection a probabilistic decoder to quantify single-cell accurately. Polaris offers unifying, turnkey solution analyzing data from multiplexed error-robust FISH (MERFISH), sequential fluorescence in situ...
Abstract While live-cell imaging is a powerful approach to studying the dynamics of cellular systems, converting these data into quantitative, single-cell records behavior has been longstanding challenge. Deep learning methods have proven capable performing cell segmentation—a critical task for analyzing data—but their performance in tracking limited by lack dynamic datasets with temporally consistent labels. We bridge this gap through integrated development labeling and deep methodology....
Features: * Problem-solving opportunities to challenge children think about concepts that they have learned in mathematics more abstract ways. Practical, hands-on activities which pupils actively explore through such as measuring, making models and so on. Talk points encourage make links connections between the real world verbalise communicate their ideas. Literacy support form of develop reading, writing, speaking listening skills. Interactive group process information pose own questions...
Alzheimer disease and other dementias present unique practical challenges for patients, their families, clinicians, health systems. These reflect not only the growing public effect of dementia in an aging global population, but also more specific ethical complexities including early loss patients9 capacity to make decisions regarding own care, stigma often associated with a diagnosis, difficulty balancing concern welfare respect remaining independence, on physical, emotional, financial...
Abstract Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis that distinctly characterized granuloma formation within infected tissues. Granulomas are dynamic and organized immune cell aggregates limit dissemination, but can also hinder bacterial clearance. Consequently, outcome in TB influenced how structure composition shift the balance between these two functions. To date, our understanding of what factors drive function humans limited. With this mind, we used...
Abstract Deep learning is transforming the analysis of biological images but applying these models to large datasets remains challenging. Here we describe DeepCell Kiosk, cloud-native software that dynamically scales deep workflows accommodate imaging datasets. To demonstrate scalability and affordability this software, identified cell nuclei in 10 6 1-megapixel ~5.5 h for ~$250, with a sub-$100 cost achievable depending on cluster configuration. The Kiosk can be downloaded at...
Introduction: Democratization as a Transitional Stage Explaining Democratization: An Alternative to Existing Conceptualizations Institutional Structures and Modern Authoritarianism Independence the Legitimazation of Authoritarian Rule Political Insecurity Power Politics Problem The Ethnopolitical-Democratization Conflict Nexus Military Corporate Interests External Imperatives: International Donors Conclusion Index
Abstract Image-based spatial transcriptomics methods enable transcriptome-scale gene expression measurements with information but require complex, manually-tuned analysis pipelines. We present Polaris, an pipeline for image-based that combines deep learning models cell segmentation and spot detection a probabilistic decoder to quantify single-cell accurately. Polaris offers unifying, turnkey solution analyzing data from MERFSIH, seqFISH, or ISS experiments. is available through the DeepCell...
Part 1 Class formation and cultural continuity in Nigeria: the contribution of tribalism to nationalism Western Nigeria political parties during era independence three perspectives on hierarchy contradictions Nigerian system ordeal Chief Awolowo politics perspective, with a postscript. 2 culture Africa: dysrhythmic process change science national integration - radical approach nature class domination Africa. 3 Democracy development: second beginnings new framework democracy Africa unfinished...
Our Common Future. World Commission on Environment and Development, London New York: Oxford University Press. 383 pp. Decolonising India National Thought the Colonial World. Partha Chatterjee, London: Zed Books, 1986 Traditions, Tyranny Utopias. Ashis Nandy, Delhi: Press, 1987 South Africa in Transition Power Plays: Bargaining Tactics for Transforming Africa. Pierre du Toit, Halfway House: Southern Book Publishers. 150pp R43.99 pb to Democracy: Policy Perspectives 1991. Robin Lee Lawrence...
ABSTRACT This paper analyses the current democratization project as a major ideological pillar in structure of international hegemony. An examination main agents and appeals neo-liberal is followed by description principal classes groups who support it. The heterogeneous mass basis for underlies “struggle definition” that now taking place. Challenging definition democratization, article “deconstructs” economic liberalism into “decommodification,” political “polyarchization.” redefinition...
ABSTRACT T cell therapies, such as chimeric antigen receptor (CAR) cells and (TCR) cells, are a growing class of anti-cancer treatments. However, expansion to novel indications beyond last-line treatment requires engineering cells’ dynamic population behaviors. Here we develop the tools for cellular behavior analysis from live-cell imaging, common inexpensive experimental setup used evaluate engineered cells. We first state-of-the-art segmentation tracking pipeline, Caliban , based on...