A5090892360- Pain Management and Treatment
- Facial Rejuvenation and Surgery Techniques
- Stroke Rehabilitation and Recovery
- Nerve injury and regeneration
- LGBTQ Health, Identity, and Policy
- Cell Image Analysis Techniques
- Surgical Sutures and Adhesives
- Reconstructive Surgery and Microvascular Techniques
- Nerve Injury and Rehabilitation
- Botulinum Toxin and Related Neurological Disorders
- Facial Nerve Paralysis Treatment and Research
- Emergency and Acute Care Studies
- Digital Imaging in Medicine
- Organ and Tissue Transplantation Research
- Prosthetics and Rehabilitation Robotics
- Cleft Lip and Palate Research
- Single-cell and spatial transcriptomics
- Female Genital Mutilation/Cutting Issues
- Protein Interaction Studies and Fluorescence Analysis
- Cardiac Arrest and Resuscitation
- Image Processing Techniques and Applications
- Nonmelanoma Skin Cancer Studies
- COVID-19 diagnosis using AI
- Tracheal and airway disorders
- RNA Research and Splicing
MedStar Georgetown University Hospital
2018-2024
Georgetown University
2018-2024
Yale University
2024
Creative Commons
2020-2023
Washington Center
2021-2022
California Institute of Technology
2018-2021
Committee on Publication Ethics
2021
University of Pennsylvania
2015-2020
Columbia University Irving Medical Center
2020
Children's Hospital of Philadelphia
2020
Several crystal forms of serum albumin suitable for three‐dimensional structure determination have been grown. These include crystals recombinant and wild‐type human albumin, baboon canine albumin. The intrinsic limits X‐ray diffraction these are in the range 0.28–0.22 nm. Two produced from incorporated long‐chain fatty acids. Molecular replacement experiments successfully conducted on each form using previously determined atomic coordinates illustrating conserved tertiary structure.
Approximately 200,000 people undergo a lower extremity amputation each year. Following amputation, patients suffer from chronic pain, inability to ambulate, and high mortality rates. Targeted muscle reinnervation is nerve transfer procedure that redirects transected sensory mixed nerves into motor treat neuroma phantom limb pain. This study evaluates outcomes with prophylactic targeted at the time of below-knee amputation.This cohort comparing 100 undergoing primary standard traction...
The landscape of gender dysphoria has changed dramatically in recent years secondary to increased societal acceptance, legislative changes, and medical providers' awareness the associated psychosocial burden with diagnosis. National global advocacy efforts, conjunction expanded third-party insurance coverage, have resulted new health care opportunities for patients suffering from dysphoria. Delivering quality, streamlined these requires a complex multidisciplinary approach, involving...
There are numerous methods of assessing patient satisfaction with botulinum toxin type A neuromodulation the glabellar rhytids. As use aesthetic increases both in breadth and number procedures, there is a need for more comprehensive tools to evaluate patient-reported outcomes. The FACE-Q recently validated outcome instrument that can be used measure perceptions neuromodulation.This study assess following rhytids.57 female patients completed FACE-Q, survey evaluates patients' their facial...
Many splicing factors interact with both mRNA and pre-mRNA. The identification of these interactions has been greatly improved by the development in vivo cross-linking immunoprecipitation. However, output carries a strong sampling bias favor RNPs that form on more abundant RNA species like mRNA. We have developed novel vitro approach for surveying binding pre-mRNA, without or bias. Briefly, this entails specifically designed oligonucleotide pools tile through pre-mRNA sequence. pool is then...
Background: Cleft repair requires multiple operations from infancy through adolescence, with repeated exposure to opioids and their associated risks. The authors implemented a quality improvement project reduce perioperative opioid in cleft lip/palate population. Methods: After identifying key drivers of administration, interventions were developed address these postoperative administration 0.30 mg/kg morphine equivalents 0.20 equivalents. Data retrospectively collected January 1, 2015,...
Summary: Symptomatic neuromas can cause debilitating pain, significantly impairing patients’ quality of life. There are numerous medical and surgical options for management. Targeted muscle reinnervation (TMR) is a nerve transfer procedure that now commonly used to prevent or treat symptomatic phantom limb pain in amputees. few reports the current literature about performing TMR nonamputee, but no cohort studies date report outcomes. This study evaluates nonamputee patients. retrospective...
Patients with major lower limb amputations suffer from symptomatic neuromas and phantom-limb pain due to their transected nerves. Peripheral nerve surgery techniques, such as targeted muscle reinnervation regenerative peripheral interface, aim physiologically prevent this nerve-specific pain. No studies have specifically reported on which nerves most frequently cause chronic The authors studied the incidence of neuroma formation phantom in patients undergoing a below-knee amputation, better...
U.S. Food and Drug Administration-approved formulations of botulinum toxin include onabotulinumtoxinA (Botox; Allergan, Inc., Irvine, Calif.), abobotulinumtoxinA (Dysport; Galderma Pharma S.A., Lausanne, Switzerland), incobotulinumtoxinA (Xeomin; Merz Pharmaceuticals GmbH, Frankfurt am Main, Germany). This study uses digital image correlation to compare dynamic strain reduction between available neurotoxins.Seventy-three treatment-naive female patients aged were randomized injection with (20...
Abstract Background Amputees frequently suffer from chronic pain in both their residual limbs (RLP) and phantom (PLP) following amputation. Targeted muscle reinnervation (TMR) is a nerve transfer technique that has been demonstrated to improve secondarily at time of The goal this study report on the efficacy primary TMR above-knee level amputations setting limb-threatening ischemia or infection. Methods This retrospective review single-surgeon experience with patients undergoing through-...
Abstract Background The perioral region is the most dynamic anatomic area of face and subject to complex dramatic changes during aging. Successful treatment for rejuvenation has yet be identified, prior studies have reported only subjective outcomes. Objectives purpose this study was utilize our validated 3-dimensional imaging technology determine whether conservative neuromodulation combined with hyaluronic acid filler volumization can decrease strain increase volume significant patient...
Abstract Deep learning is transforming the analysis of biological images but applying these models to large datasets remains challenging. Here we describe DeepCell Kiosk, cloud-native software that dynamically scales deep workflows accommodate imaging datasets. To demonstrate scalability and affordability this software, identified cell nuclei in 10 6 1-megapixel ~5.5 h for ~$250, with a sub-$100 cost achievable depending on cluster configuration. The Kiosk can be downloaded at...
Objective: The purpose of this study was to characterize intraoperative palatal lengthening with the modified Furlow cleft repair and determine whether correlated preoperative width, type, or operating surgeon. Design: Retrospective study. Setting: Academic tertiary care pediatric hospital. Patients: One hundred eighty patients undergoing primary secondary palatoplasty using technique. Interventions: Cleft lengths widths were measured pre- post-Furlow repair. Main Outcome Measures: Immediate...
To determine pre- and postoperative prevalence of obstructive sleep apnea (OSA) in patients with 22q11.2 deletion syndrome (DS) undergoing wide posterior pharyngeal flap (PPF) surgery for velopharyngeal dysfunction (VPD).Retrospective study using polysomnography (PSG) to OSA. Medical records were reviewed patients' medical comorbidities. Parents surveyed about snoring.Academic tertiary care pediatric hospital.Forty laboratory confirmed 22q11.2DS followed over a 6-year period.Pre- PSG, speech...
Life does not end after a major lower extremity amputation. With advances in surgical technique and sophistication capabilities of prosthetics, patients should be reasonably expected to return most their pre-amputation physical capabilities. This article highlights management operative principles that will optimize patients' function quality life following
Alcohol use is a major and unpredictable driver of emergency department (ED) visits. Regional Twitter activity correlates ecologically with behavioral outcomes. No such correlation has been established in real time. The objective was to examine the between real-time, alcohol-related tweets ED We developed piloted set 11 keywords that identified related alcohol use. In-state were using self-declared profile information or geographic coordinates. Using Datasift, third-party vendor, random...
Background: The toolbox for cosmetic practitioners is growing at an unprecedented rate. There are novel products every year and expanding off-label indications neurotoxin soft-tissue filler applications. Consequently, aesthetic physicians increasingly challenged by the task of selecting most appropriate techniques to achieve optimal patient outcomes. Methods: We employed a PubMed literature search facial injectables from past 10 years (2005–2015), with emphasis on those articles embracing...
This study aims to better understand patient-reported outcomes for iliac bone grafting surgery alveolar cleft repair and determine how standardizing perioperative patient instruction affects outcomes.Retrospective survey-based assessment of patients undergoing with without hospital-based systems standardization.Academic tertiary care hospital.Of the 195 identified patients, 127 participated.Survey on pain satisfaction regarding surgery.Survey answers measured opinions about surgery. Answers...