A5051431598- Xenotransplantation and immune response
- Climate Change, Adaptation, Migration
- Wildlife Ecology and Conservation
- Pancreatic and Hepatic Oncology Research
- Coral and Marine Ecosystems Studies
- Sustainability and Climate Change Governance
- Indigenous Studies and Ecology
- Climate change impacts on agriculture
- Pancreatitis Pathology and Treatment
- Animal Genetics and Reproduction
- Fish Ecology and Management Studies
- Human-Animal Interaction Studies
- Land Use and Ecosystem Services
- Conservation, Biodiversity, and Resource Management
- Organ Transplantation Techniques and Outcomes
- Coastal and Marine Management
- Marine and fisheries research
- CRISPR and Genetic Engineering
- Marine animal studies overview
- Liver Disease Diagnosis and Treatment
- Virus-based gene therapy research
- Pacific and Southeast Asian Studies
- Agricultural Innovations and Practices
- Island Studies and Pacific Affairs
- Zoonotic diseases and public health
Indiana University – Purdue University Indianapolis
2015-2025
Indiana University School of Medicine
2015-2025
Cawthron Institute
2024-2025
CSIRO Land and Water
2015-2024
Indiana University
2015-2024
University School
2024
Northumbria Healthcare NHS Foundation Trust
2024
Commonwealth Scientific and Industrial Research Organisation
2010-2023
Indiana University Bloomington
2023
Intellia Therapeutics (United States)
2022
Oteros-Rozas, E., B. Martín-López, T. Daw, E. L. Bohensky, J. Butler, R. Hill, Martin-Ortega, A. Quinlan, F. Ravera, I. Ruiz-Mallén, M. Thyresson, Mistry, Palomo, G. D. Peterson, Plieninger, K. Waylen, Beach, C. Bohnet, Hamann, Hanspach, Hubacek, S. Lavorel and Vilardy 2015. Participatory scenario planning in place-based social-ecological research: insights experiences from 23 case studies. Ecology Society 20(4):32.http://dx.doi.org/10.5751/ES-07985-200432
Abstract Background Simultaneous inactivation of pig GGTA 1 and CMAH genes eliminates carbohydrate xenoantigens recognized by human antibodies. The β4Gal NT 2 glycosyltransferase may also synthesize xenoantigens. To further characterize glycan‐based species incompatibilities, we examined non‐human primate antibody binding to cells derived from genetically modified pigs lacking these carbohydrate‐modifying genes. Methods Cas9 endonuclease gRNA were used create 1, 1/ , or /β4Gal Peripheral...
Macrophages serve to maintain organ homeostasis in response challenges from injury, inflammation, malignancy, particulate exposure, or infection. Until now, receptor ligation has been understood as being the central mechanism that regulates macrophage function. Using macrophages of different origins and species, we report elasticity is a major determinant innate Macrophage modulated not only by classical biologic activators such LPS IFN-γ, but an equal extent substrate rigidity stretch....
Motivated by donor interest in innovative thinking on food security, we conducted an interdisciplinary, triangulation analysis of four divergent conceptual frameworks, each relevant to diagnosing insecurity developing countries. We found notable tensions as well synergistic interactions between agroecology, agricultural innovation systems, social–ecological and political ecology. Cross-framework enhance our understanding how sectoral macro-economic development strategies impact livelihoods,...
Antipig antibodies are a barrier to clinical xenotransplantation. We evaluated antibody binding of waitlisted renal transplant patients 3 glycan knockout (KO) pig cells and class I swine leukocyte antigens (SLA).Peripheral blood mononuclear from SLA identical wild type (WT), α1, 3-galactosyltransferase (GGTA1) KO, GGTA1/ cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) CMAH /b1,4 N-acetylgalactosaminyl transferase (B4GalNT2) KO pigs were screened for human using flow...
Climate adaptation planning provides an opportunity to enhance the adaptive capacity of stakeholders across multiple levels. However, reviews standard top-down and bottom-up approaches indicate that value multistakeholder involvement is not fully recognized or incorporated into guidelines. Focusing on provinces in Indonesia Papua New Guinea within Coral Triangle region, we present a novel integrated approach. Based Participatory Systemic Inquiry process involves three stages workshops...
Adaptation to climate change is a social–ecological process: it not solely result of natural processes or human decisions but emerges from multiple relations within social systems, ecological systems and between them. We propose novel analytical framework evaluate in nature-based adaptation, encompassing (people–people), (nature–nature) (people–nature) relations. Applying this 25 case studies, we analyse the associations among these identify archetypes adaptation. Our findings revealed that...
Butler, J. R. A., A. Tawake, T. Skewes, L. and V. McGrath. 2012. Integrating traditional ecological knowledge fisheries management in the Torres Strait, Australia: catalytic role of turtles dugong as cultural keystone species. Ecology Society 17(4): 34. https://doi.org/10.5751/ES-05165-170434
Abstract Background Manipulating the pig genome to increase compatibility with human biology may facilitate clinical application of xenotransplantation. Genetic modifications cells have been made by sequential recombination in fetal fibroblasts and liver‐derived followed cross‐breeding or somatic cell nuclear transfer. The generation pigs for research organ donation these methods is slow, expensive requires technical expertise. A novel system incorporating bacterial nuclease C as9...
Mainstreaming climate change and future uncertainty into rural development planning in developing countries is a pressing challenge. By taking complex systems approach to decision-making, the adaptation pathways construct provides useful principles. However, there are no examples of how operationalise countries, or evaluate process. This paper describes 4 year governance experiment Nusa Tenggara Barat Province, Indonesia, which applied adaptive co-management (ACM) as ‘prime’ transformation...
Few studies have examined how to mainstream future climate change uncertainty into decision-making for poverty alleviation in developing countries. With potentially drastic emerging later this century, there is an imperative develop planning tools which can enable vulnerable rural communities proactively build adaptive capacity and ‘leap-frog’ the Sustainable Development Goals (SDGs). Using example from Indonesia, we present a novel participatory approach achieve this. We applied scenario...
The claim that in natural resource management (NRM) a change from anthropocentric values and ethics to eco-centric ones is necessary achieve sustainability leads the search for models of relationship with environment. Indigenous cultures can provide such models; hence, there need multicultural societies further include their NRM. In this article, we investigate environmental placed on freshwater environment Wet Tropics by community indigenous Australians. We discuss as human values, so...
By linking iterative learning and knowledge generation with power-sharing, adaptive co-management (ACM) provides a potential solution to resolving complex social-ecological problems. In this paper we evaluate ACM as mechanism for conservation conflict using case study in Scotland, where seal salmon fishery stakeholders have opposing entrenched objectives. emerged 2002, successfully long-standing conflict. Applying evaluation approaches from the literature, 2011 interviewed characterise...
Abel, N., R. M. Wise, J. Colloff, B. H. Walker, A. Butler, P. Ryan, C. Norman, Langston, Anderies, Gorddard, Dunlop, and D. O’Connell. 2016. Building resilient pathways to transformation when “no one is in charge”: insights from Australia's Murray-Darling Basin. Ecology Society 21(2):23.http://dx.doi.org/10.5751/ES-08422-210223
Abstract Understanding the distribution of biodiversity across Earth is one most challenging questions in biology. Much research has been directed at explaining species latitudinal pattern showing that communities are richer tropical areas; however, despite decades research, a general consensus not yet emerged. In addition, global patterns being rapidly altered by human activities. Here, we aim to describe large‐scale richness and diversity terrestrial vertebrate scavenger...
Human actions have driven earth systems close to irreversible and profound change. The need shift towards intentional transformative adaptation (ITA) is clear. Using case studies from the Transformative Adaptation Research Alliance (TARA), we explore ITA as a way of thinking acting that in concept objectives, but achieved through mix incremental co-production processes ultimately lead social-ecological system being transformed. Central are social political issues how individuals collectives...
The COVID-19 pandemic has impacted global food systems. This led to different strategies by communities, governments, and businesses involved in systems mitigate adapt the unfolding pandemic. Small Island Developing States are particularly exposed conflation of risks from disease, economic downturns, underlying climate vulnerabilities biosecurity risks.Our study aimed identify vulnerabilities, impacts, opportunities for supporting resilience sustainable development selected Pacific...
SUMMARY Despite being heavily infiltrated by immune cells, tuberculosis (TB) granulomas often subvert the host response to Mycobacterium (Mtb) infection and support bacterial persistence. We previously discovered that human TB are enriched for immunosuppressive factors typically associated with tumor-immune evasion, raising intriguing possibility they promote tolerance infection. In this study, our goal was identify prime drivers establishing tolerogenic niche determine if magnitude of...