A5101986372- HER2/EGFR in Cancer Research
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Treatments and Studies
- Monoclonal and Polyclonal Antibodies Research
- Proteoglycans and glycosaminoglycans research
- Cancer Treatment and Pharmacology
- Cancer Cells and Metastasis
- Neuroblastoma Research and Treatments
- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Lung Cancer Research Studies
- Radiopharmaceutical Chemistry and Applications
- Fibroblast Growth Factor Research
- Glycosylation and Glycoproteins Research
- Angiogenesis and VEGF in Cancer
- Medical Imaging Techniques and Applications
- Ovarian cancer diagnosis and treatment
- Advanced biosensing and bioanalysis techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Sphingolipid Metabolism and Signaling
- Lung Cancer Treatments and Mutations
- Medical Imaging and Pathology Studies
- Inflammatory mediators and NSAID effects
- Gastrointestinal Tumor Research and Treatment
- Click Chemistry and Applications
The University of Texas Health Science Center at Houston
2016-2025
Brown Foundation
2016-2025
Institute of Molecular Medicine
2015-2016
CSL (Australia)
2014
The University of Texas MD Anderson Cancer Center
2003-2012
Texas Medical Center
2003
Centre d’Élaboration de Matériaux et d’Études Structurales
2003
Centre National de la Recherche Scientifique
2003
The University of Melbourne
2002
National Institute of Immunology
1992-1999
Numerous human tumor types, including ovarian cancer, display a significant expression of the CD44 family cell surface proteoglycans. To develop tumortargeted drugs, we have initially evaluated whether ligand hyaluronic acid (HA) could serve as backbone for paclitaxel (TXL) prodrugs. HA-TXL was prepared by modification previous techniques. The in vitro cytotoxicity against CD44(+) carcinoma lines SKOV-3ip and NMP-1 be significantly blocked preincubation with molar excess free HA. Female nude...
Abstract Gastrointestinal cancer is one of the leading causes cancer-related mortality in men and women worldwide. The adult stem cell marker LGR5 (leucine-rich repeat-containing, G protein–coupled receptor 5) highly expressed a significant fraction gastrointestinal tumors colon, liver, pancreas, stomach, relative to normal tissues. located on surface undergoes rapid, constitutive internalization independent ligand. Furthermore, LGR5-high cells have been shown exhibit properties...
Enhancer aberrations are beginning to emerge as a key epigenetic feature of colorectal cancers (CRC), however, comprehensive knowledge chromatin state patterns in tumour progression, heterogeneity these and imparted therapeutic opportunities remain poorly described.We performed epigenomic characterisation by mapping 222 profiles from 69 samples (33 adenocarcinomas, 4 adenomas, 21 matched normal tissues 11 colon cancer cell lines) for six histone modification marks: H3K4me3 Pol II-bound...
Most primary human ovarian tumors and peritoneal implants, as well tumor vascular endothelial cells, express the CD44 family of cell surface proteoglycans, natural ligand for which is hyaluronic acid. Metronomic dosing, frequent administration chemotherapeutics at substantially lower than maximum tolerated doses (MTD), has been shown to result in reduced normal tissue toxicity minimize "off-treatment" exposure resulting an improved therapeutic ratio.We tested hypothesis that acid (HA)...
Gastroenteropancreatic neuroendocrine neoplasms (GEP NENs) are rare cancers consisting of carcinomas (NECs) and tumors (NETs), which have been increasing in incidence recent years. Few cell lines pre-clinical models exist for studying GEP NECs NETs, limiting the ability to discover novel imaging treatment modalities. To address this gap, we isolated tumor cells from cryopreserved patient NETs injected them into flanks immunocompromised mice establish patient-derived xenograft (PDX) models....
While the clinical use of radiolabeled somatostatin analogs is well established in neuroendocrine tumors, there growing interest expanding their application to other receptor 2 (SSTR2)-expressing cancers. This study investigates potential utility SSTR2-targeted theranostics hepatocellular carcinoma (HCC). SSTR2 expression HCC cell lines and samples was evaluated using qRT-PCR, Western blot analysis, a public dataset. 67Ga-DOTATATE uptake measured, 177Lu-DOTATATE cytotoxicity assessed,...
(1) Background: Somatostatin receptor 2 (SSTR2) is overexpressed in various tumors, in-cluding hepatocellular carcinoma (HCC), yet its role tumorigenesis remains unclear. This study examines the roles of SSTR2 molecular pathology HCC and explores potential as a target for SSTR2-directed radiopharmaceuticals this malignancy. (2) Methods: expression was analyzed across 22 malignancies using TNMplot specifically through The Human Protein Atlas. Transcriptomic data, protein expression, copy...
<p>HPLC and deconvoluted ESI-MS analysis of DBCO-PEG3-EGCit-PABQ-Duocarmycin DM-gluc (purity >95%).</p>
<p>Safety assessment for H231 VC-cDuoDM, EGC-cDuoDM, and EGC-qDuoDM gluc ADCs.</p>
<p>Characterization of EREG-targeting antibody-drug conjugates.</p>
<p>Characterization of EREG mAbs and non-targeting control mAb binding.</p>
<p>Chemical structures of duocarmycin-based linker-payloads.</p>
<p>Biomarker expression and Kaplan-Meier survival plots bodyweight measurements from efficacy studies.</p>
<p>IC50 values for EREG-targeting H231 ADCs in a panel of colorectal cancer cell lines.</p>
<p>Characterization of DFO-H231 and 89Zr-DFO-H231 conjugates.</p>
<p>EREG expression in normal tissues and cancer cell lines.</p>
<p>Size-exclusion chromatography analysis after ceramic hydroxyapatite XT (CHT-XT) purification for each of the H231 ADCs.</p>
<div>Abstract<p>As colorectal cancer remains a leading cause of cancer-related death, identifying therapeutic targets and approaches is essential to improve patient outcomes. The EGFR ligand epiregulin (EREG) highly expressed in RAS wild-type (WT) mutant cancer, with minimal expression normal tissues, making it an attractive target for antibody–drug conjugate (ADC) development. In this study, we produced purified EREG mAb, H231, which had high specificity affinity human mouse...
<p>Cytotoxicity dose-response curves of EREG-targeting antibody-drug conjugates.</p>