A5066706584- Radiopharmaceutical Chemistry and Applications
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Medical Imaging Techniques and Applications
- Peptidase Inhibition and Analysis
- Prostate Cancer Treatment and Research
- Radiation Therapy and Dosimetry
- Medical Imaging and Pathology Studies
- Lanthanide and Transition Metal Complexes
- Metal complexes synthesis and properties
- Monoclonal and Polyclonal Antibodies Research
- Nanoplatforms for cancer theranostics
- Bone health and treatments
- Neuroendocrine Tumor Research Advances
- Porphyrin and Phthalocyanine Chemistry
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Lung Cancer Treatments and Mutations
- Orthopaedic implants and arthroplasty
- Ocular Oncology and Treatments
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Advanced MRI Techniques and Applications
- Boron Compounds in Chemistry
- Cystic Fibrosis Research Advances
University of Iowa
2020-2025
University of Iowa Hospitals and Clinics
2024
University of Iowa Health Care
2021
Wake Forest University
2011-2019
Winston-Salem/Forsyth County Schools
2014-2018
Modulation Therapeutics (United States)
2016
Mallinckrodt (United States)
2006-2015
University of New Hampshire
2010
University of New Hampshire at Manchester
2010
Washington University in St. Louis
2007
A novel Pt(II) terpyridine complex that has a nicotinamide moiety linked to the terpyridyl ligand been synthesized in good yield and studied structurally spectroscopically. The complex, [Pt(Nttpy)Cl](PF6)2 where Nttpy = 4'-(p-nicotinamide-N-methylphenyl)-2,2':6',2' '-terpyridine, is observed be brightly luminescent solid state at room temperature 77 K. exhibits reversible vapochromic behavior crystallographic change presence of several volatile organic solvents. Upon exposure methanol...
Photoinduced charge separation is a fundamental step in photochemical energy conversion. In the design of molecularly based systems for light-to-chemical conversion, this studied through construction two- and three-component (dyads triads) having suitable electron donor acceptor moieties placed at specific positions on charge-transfer chromophore. The most extensively chromophores regard are ruthenium(II) tris(diimine) with common 3MLCT excited state, as well related bis(terpyridyl) systems....
<sup>89</sup>Zr–Tetraazamacrocycle complexes display extraordinary stability.
Abstract Speciation leads to adaptive changes in organ cellular physiology and creates challenges for studying rare cell-type functions that diverge between humans mice. Rare cystic fibrosis transmembrane conductance regulator (CFTR)-rich pulmonary ionocytes exist throughout the cartilaginous airways of 1,2 , but limited presence divergent biology proximal trachea mice has prevented use traditional transgenic models elucidate ionocyte airway. Here we describe creation conditional genetic...
// Anirudh Sattiraju 1, 2, * , Kiran Kumar Solingapuram Sai Ang Xuan 4, Darpan N. Pandya 2 Frankis G. Almaguel 1 Thaddeus J. Wadas 3 Denise M. Herpai Waldemar Debinski and Akiva Mintz Department of Radiology, Wake Forest School Medicine, Winston-Salem, NC 27157, USA Brain Tumor Center Excellence, University Comprehensive Cancer Center, Biology, 4 Nuclear Medicine The People's Hospital Zhengzhou University, Zhengzhou, Henan 450003, China These authors contributed equally to this work...
The theranostic potential of (225)Ac-based radiopharmaceuticals continues to increase as researchers seek innovative ways harness the nuclear decay this radioisotope for therapeutic and imaging applications. This communication describes evaluation (225)Ac-DOTA-c(RGDyK) in both biodistribution Cerenkov luminescence (CLI) studies. Initially, La-DOTA-c(RGDyK) was prepared a non-radioactive surrogate evaluate methodologies that would contribute an optimized radiochemical synthetic strategy...
A new terpyridyl-containing Pt triad [Pt(pytpy)(p-CC-C6H4-NH-CO-C6H2(OMe)3)](PF6)2 (4), where pytpy = 4'-(4-pyridin-1-ylmethylphenyl)-[2,2';6',2' ']terpyridine and p-CC-C6H4-NH-CO-C6H2(OMe)3 N-(4-ethynylphenyl)-3,4,5-trimethoxybenzamide, has been synthesized structurally characterized. The related donor-chromophore dyad [Pt(ttpy)(p-CC-C6H4-NH-CO-C6H2(OMe)3)]PF6 2, ttpy 4'-p-tolyl-[2,2';6',2' ']terpyridine, the chromophore-acceptor [Pt(pytpy)(CCC6H5)](PF6)2 (3), CCC6H5 ethynylbenzene, have...
New Pt(II) diimine bis(acetylide) complexes where the is a substituted bipyridine or phenanthroline and arylacetylide 4-ethynylbenzaldehyde have been prepared in good to excellent yields. Spectroscopic characterization supports square planar coordination geometry with cis-alkynyl ligands, crystal structure of one complexes, Pt(phen)(C⋮CC6H4CHO)2 (1), confirms assignment. The new exhibit an absorption band ca. 400 nm that corresponds Pt(d) → π* charge transfer transition are brightly emissive...
Recently, the somatostatin receptor subtype 2 (SSTR2) selective antagonist sst<sub>2</sub>-ANT was determined to have a high affinity for SSTR2. Additionally, <sup>111</sup>In-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-sst<sub>2</sub>-ANT showed uptake in an SSTR2-transfected, tumor-bearing mouse model and suggested that radiolabeled SSTR2 antagonists may be superior agonists imaging SSTR2-positive tumors. This report describes synthesis evaluation of...
A novel octadentate 3-hydroxypyridin-2-one (2,3-HOPO) based di-macrocyclic ligand was evaluated for chelation of 89 Zr; subsequently, it used as a bi-functional chelator preparation Zr-labeled antibodies.Quantitative Zr 4+ with the forming ZrL complex achieved under mild conditions within 15 minutes.The Zr-complex stable in vitro presence DTPA, but slow degradation observed serum.In vivo, hydrophilic showed prevalently renal excretion; and an elevated bone uptake radioactivity suggested...
Octadentate terephthalamide ligands can be easily radiolabeled with <sup>89</sup>Zr and are highly stable <italic>in vitro</italic>. They represent a novel class of bifunctional chelators for <sup>89</sup>Zr.
New effective therapies are greatly needed for metastatic uveal melanoma, which has a very poor prognosis with median survival of less than 1 y. The melanocortin receptor (MC1R) is expressed in 94% melanoma metastases, and MC1R-specific ligand (MC1RL) high affinity selectivity MC1R was previously developed. <b>Methods:</b> <sup>225</sup>Ac-DOTA-MC1RL conjugate synthesized radiochemical yield purity tested vitro biostability cytotoxicity cells, the lanthanum-DOTA-MC1RL analog binding...
Gastroenteropancreatic neuroendocrine neoplasms (GEP NENs) are rare cancers consisting of carcinomas (NECs) and tumors (NETs), which have been increasing in incidence recent years. Few cell lines pre-clinical models exist for studying GEP NECs NETs, limiting the ability to discover novel imaging treatment modalities. To address this gap, we isolated tumor cells from cryopreserved patient NETs injected them into flanks immunocompromised mice establish patient-derived xenograft (PDX) models....
The single domain antibody, I3, interacts with fibroblast activation protein alpha through its CDR3 loop and FR2 region to bind a unique previously undisclosed epitope that is distinct from the protease's active site.
The luminescent complex Pt(dpphen)bis(arylacetylide) (1) (dpphen = 4,7-diphenylphenanthroline and arylacetylide 4-ethynylbenzaldehyde) has been synthesized characterized structurally spectroscopically. Complex 1 employed in the synthesis of donor−chromophore (D−C) dyads through Schiff base condensations different anilines to give imine-linked 2−4 imine reduction with borohydride, corresponding amine-linked 2a−4a. Crystal structure determinations 1−4 4a establish a distorted square-planar...
A cross-bridged cyclam ligand bearing two N-carboxymethyl pendant arms (1) has been found to form a copper(II) complex that exhibits significantly improved biological behavior in recent research towards 64Cu-based radiopharmaceuticals. Both the kinetic inertness and resistance reduction of Cu–1 are believed be relevant its enhanced performance. To explore influence arm length on these properties, new cyclen ligands with longer N-carboxyethyl arms, 2 4, their respective complexes have...