A5054368673- Skin Protection and Aging
- Immunotherapy and Immune Responses
- Dermatology and Skin Diseases
- Immune Response and Inflammation
- Psoriasis: Treatment and Pathogenesis
- Cancer Immunotherapy and Biomarkers
- melanin and skin pigmentation
- Cutaneous Melanoma Detection and Management
- Bee Products Chemical Analysis
- Immune Cell Function and Interaction
- Nonmelanoma Skin Cancer Studies
- Hidradenitis Suppurativa and Treatments
- Immune cells in cancer
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- T-cell and B-cell Immunology
- Genomics, phytochemicals, and oxidative stress
- Photodynamic Therapy Research Studies
- Colorectal and Anal Carcinomas
- Epigenetics and DNA Methylation
- Autoimmune Bullous Skin Diseases
- Phytochemicals and Antioxidant Activities
- Cancer-related Molecular Pathways
- Acne and Rosacea Treatments and Effects
- Anorectal Disease Treatments and Outcomes
University of Alabama at Birmingham
2015-2025
University of Alabama
2025
Birmingham VA Medical Center
2011-2022
Creative Commons
2022
Christie's
2022
Hudson Institute
2018
John Wiley & Sons (United States)
2018
Dermatology Research Center
2010-2017
Universiti Sains Malaysia
2012
In-Q-Tel
2011
The role of immune responses in tumor development is a central issue for biology and immunology. IL-17 an important cytokine inflammatory autoimmune diseases. Although IL-17-producing cells are detected cancer patients tumor-bearing mice, the controversial, mechanisms remain to be fully elucidated. In current study, we found that tumors was inhibited IL-17R-deficient mice. A defect IFN-gammaR increased growth, whereas growth mice were deficient both IL-17R compared with wild-type animals....
Abstract Background Studies have begun to investigate the complex relationship between host and microorganisms in non‐infectious pathologies such as acne, atopic dermatitis psoriasis. Though skin is exposed environmental stressors ultraviolet radiation ( UVR ), no studies exist examining effects of both UVA UVB on microbiome. Objective To test effect human Methods whether UV will alter cutaneous microbiome, participants were doses (22‐47 J/cm 2 ) or (100‐350 mJ /cm samples collected. DNA was...
The mechanism for inflammation associated tumor development is a central issue biology and immunology remains to be fully elucidated. Although IL-17 implicated in association with mediated carcinogenesis, mechanisms are largely elusive. In the current studies, we showed that receptor-A gene deficient (IL-17R-/-) mice were resistant chemical carcinogen-induced cutaneous well-established model skin. deficiency IL-17R increased infiltration of CD8+ T cells whereas it inhibited CD11b+ myeloid...
Doxorubicin (DOX) is a widely used drug for cancer treatment as chemotherapeutic agent. However, the cellular and integrative mechanism of DOX-induced immunometabolism unclear. Two-month-old male C57BL/6J mice were divided into high- low-dose DOX-treated groups with maintained saline control group. The first group was injected high dose DOX (H-DOX; 15 mg·kg-1·wk-1), second 7.5 mg·kg-1·wk-1 latent low (LL-DOX). H-DOX led to complete mortality in 2 wk 70% survival LL-DOX compared Therefore, an...
The latest research shows that current chemotherapeutics are ineffective because of the development resistance in cervical cancer cells, and hence, their scope use is limited. main concern researchers at moment discovery safe effective antiproliferative plant chemicals can aid battle against cancer. Previous studies have shown possible anticancer potential phenethyl isothiocyanate obtained from cruciferous plants for many cancers, which targets various signaling pathways to exercise...
Introduction: Studies on the association between immune-mediated disorders and lymphoid have been very limited, especially in diverse populations. The objective of this study is to evaluate relationship a variety immune diseases malignancies. Methods: NIH “All Us” database was utilized perform cross-sectional analysis various diseases. adjusted multivariable logistic regression performed R examine such as leukemia, lymphoma, plasma cell neoplasms against autoimmune Results: In cohort 316,044...
Abstract Toll-like receptors (TLR) activate multiple steps in inflammatory reactions innate immune responses. They also signals that are critically involved the initiation of adaptive Many tumorigenic chemicals have been associated with endotoxin hypersensitivity mediated through TLR4. To determine role TLR4 cutaneous skin carcinogenesis, we treated TLR4-deficient C3H/HeJ mice and TLR4-normal C3H/HeN carcinogenic polyaromatic hydrocarbon 7,12-dimethylbenz(a)anthracene (DMBA). developed more...
Abstract Proteomic analysis of murine skin has shown that a variety heat shock proteins (HSPs) are constitutively expressed in the skin. Using allergic contact hypersensitivity as model, we investigated role two proteins, HSP27 and HSP70, induction cutaneous cell-mediated immune responses. Immunohistochemical examination specimens showed was present epidermis HSP70 both dermis. Inhibition produced reduction 1-fluoro-2,4-dinitrobenzene response resulted Ag-specific unresponsiveness. Treatment...
Breast cancer remains a major cause of death in women the developed world. As Toll-like receptors (TLRs) are widely expressed on tumor cells and play important roles initiation progression cancer, they may thus serve as targets have an effective perspective breast treatment. Expression TLRs mononuclear inflammatory can promote inflammation cell survival microenvironment. Inflammation related. It is well known that persistent conditions induce formation, due to production cytokines...
Abstract Toll‐like receptors (TLRs) activate signals that are critically involved in innate immune responses and contribute to the initiation of adaptive responses. Resveratrol ( trans ‐3,5,4‐trihydroxystilbene), a polyphenol found red grapes several other plant sources, is an effective chemopreventive agent cutaneous chemical carcinogenesis. In this study, we investigated whether TLR4 was required for action resveratrol DMBA skin For purpose, mice with normal deficient function were...
Malaysian tualang honey possesses strong antioxidant and anti-inflammatory properties. Here, we evaluated the effect of on early biomarkers photocarcinogenesis employing PAM212 mouse keratinocyte cell line. Keratinocytes were treated with (1.0%, v/v) before a single UVB (150 mJ cm(-2) ) irradiation. We found that treatment inhibited UVB-induced DNA damage, enhanced repair UVB-mediated formation cyclobutane pyrimidine dimers 8-oxo-7,8-dihydro-2'-deoxyguanosine. Treatment nuclear translocation...
Abstract The role that cell-mediated immune responses play during cutaneous carcinogenesis has received little attention. In this study, we evaluated the contribution of CD4+ and CD8+ T cells in C3H/HeN mice were subjected to a two-stage 7,12-dimethylbenz(a)anthracene (DMBA) initiation, 12-O-tetradecanoylphorbol-13-acetate (TPA) promotion skin protocol. CD8 knockout (CD8−/−) mice, allergic contact hypersensitivity DMBA was reduced compared with wild-type (WT) mice. On other hand, CD4...
Ultraviolet A (UVA) radiation contributes to skin photoaging. Baicalin, a plant-derived flavonoid, effectively absorbs UV rays and has been shown have anti-oxidant anti-inflammatory properties that may delay the photoaging process. In current study, cultured human fibroblasts were incubated with 50 μg/ml baicalin 24 hours prior 10 J/cm 2 UVA irradiation. order examine efficacy of treatment in delaying UVA-induced photoaging, we investigated aging-related markers, cell cycle changes,...