A5106130536- Tuberculosis Research and Epidemiology
- Garlic and Onion Studies
- Pregnancy and preeclampsia studies
- Thyroid Cancer Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Birth, Development, and Health
- Genomics, phytochemicals, and oxidative stress
- Natural Antidiabetic Agents Studies
- Hydrogen's biological and therapeutic effects
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Heavy Metal Exposure and Toxicity
- Diabetes and associated disorders
- Adrenal and Paraganglionic Tumors
- Lymphoma Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Monoclonal and Polyclonal Antibodies Research
- Synthesis and biological activity
- Reproductive System and Pregnancy
- Thyroid Disorders and Treatments
- Dietary Effects on Health
- Head and Neck Anomalies
- Diverse Scientific Research Studies
- Air Quality and Health Impacts
Jawaharlal Nehru Medical College Hospital
2010-2024
Aligarh Muslim University
2011-2024
Aga Khan University Hospital
1998-2024
Imam Abdulrahman Bin Faisal University
2023
Newcastle University Medicine Malaysia
2022
Dhaka National Medical College
2021
Dhaka Medical College and Hospital
2021
Aga Khan University
1993-2020
King George's Medical University
2016
University of Karachi
2015
Abstract Objective The proinflammatory cytokine interleukin‐1β (IL‐1β) induces the production of high levels nitric oxide (NO) in human chondrocytes. Green tea ( Camellia sinensis ) polyphenols are potent antiinflammatory agents and have been shown to inhibit NO tumor cell lines. In present study, we examined effect epigallocatechin‐3‐gallate (EGCG), a green polyphenol, on IL‐1β–induced primary osteoarthritis (OA) Methods Human chondrocytes were derived from OA cartilage treated with EGCG...
Meta-iodo-benzyl-guanidine labelled with 131-iodine [(131)I-mIBG] has been used extensively for imaging tumours originating from the neural crest but experience its therapeutic use is limited, particularly non-catecholamine secreting tumours. In order to assess response and potential adverse effects of administration (131)I-mIBG, we have reviewed all patients who had received this form treatment in our department.Retrospective analysis case notes neuroendocrine (131)I-mIBG were followed-up...
The use of biomarkers to predict stroke prognosis is gaining particular attention nowadays. Neuron specific enolase (NSE), which a dimeric isoenzyme the glycolytic enzyme and found mainly in neurons one such biomarker.This study was carried out on patients acute ischemic with aims determine correlation between NSE levels day admission infarct volume, severity, functional neurological outcome 30.Seventy five admitted Department Medicine were included study. Levels determined 1 using human...
The latest research shows that current chemotherapeutics are ineffective because of the development resistance in cervical cancer cells, and hence, their scope use is limited. main concern researchers at moment discovery safe effective antiproliferative plant chemicals can aid battle against cancer. Previous studies have shown possible anticancer potential phenethyl isothiocyanate obtained from cruciferous plants for many cancers, which targets various signaling pathways to exercise...
Abstract Hydrostatic pressure (HP) is thought to increase within cartilage extracellular matrix as a consequence of fluid flow inhibition. The biosynthetic response human articular chondrocytes HP in vitro varies with the load magnitude, frequency, well duration loading. We found that continuous cyclic (5 MegaPascals (MPa) for 4 h; 1 Hz frequency) induced apoptosis derived from osteoarthritic evidenced by reduced chondrocyte viability which was independent initial cell densities ranging 8.1...
Background: Schizophrenia is a chronic illness having varied etiology which affects cognition, emotion, perception, and other aspects of behavior. There are data show possible role oxidative stress disturbance in antioxidant mechanisms various neurological neuropsychiatric disorders. Materials Methods: Fifty drug-naive schizophrenic patients, who attended psychiatry outpatient department/inpatient department for the 1st time, were selected compared with 50 age-sex matched healthy controls....
To determine the prevalence of microalbuminuria and its association with hypertension other diabetic complications among Type-2 patients attending at Aga Khan University Hospital Karachi.1280 diabetes who visited outpatient department from September 2014 to August 2016 were included in study. Microalbuminuria was diagnosed if spot urinary microalbumin excretion confirmed be more than 20mg/l. Hypertension BP >140/90 or already on antihypertensive medications. Other demographic, clinical...
Three mouse monoclonal antibodies (mAbs), which define a highly restricted antigen, were obtained by simultaneous immunizations with superficial papillary bladder tumor cells and polyclonal serum against normal urothelium. The antigen was detected the avidin/biotin/peroxidase method in 30/44 tumors (68%) but only 4/27 infiltrating urothelial cancers (with much less intensity). No adult or fetal tissues tested expressed including urothelium from 40 individuals, 13 of whom had positive for...
Postmenopausal osteoporosis affects large fraction of elderly women. Oxidative stress (OS) appears to be involved in its pathogenesis. The scarcity human studies focusing on the correlation between bone mineral density (BMD) and OS postmenopausal women has prompted us study this issue.We conducted a cross sectional 95 subjects, 21-65 years age, including osteoporotic females (n = 35), healthy 30) reproductive age group 30). We measured serum antioxidant activity superoxide dismutase (SOD),...
Changes in the mRNA levels of two Mycobacterium tuberculosis genes ( fbp B known as antigen 85B, and hsp X Acr) were studied infected human monocytes. Antigen 85B is an enzyme involved cell wall biosynthesis also a major target immune response. Acr stress protein believed to be bacillary response adverse conditions non‐replicating persistence. During first 24 h intracellular infection, intramonocyte level increased 54‐fold P = 0.00001) 14.6 times comparison with 16S ribosomal rRNA. In...
Conflicting reports are available on the relationship of Iron Deficiency Anaemia (IDA) and iron therapy with oxidative stress.To study levels markers stress anti-oxidant status in children IDA to assess effect same.This prospective, single centre, hospital based was a sub-study randomized controlled trial conducted Department Paediatrics, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh collaboration Biochemistry (of same institution) between October 2009...
Chronic inflammation associated with tumor necrosis factor (TNF)‐α and reactive oxygen species (ROS) is the hallmark of tuberculosis. Mycobacterium tuberculosis (MTB) directly stimulates human monocytes to secrete TNF‐α. We show augmented expression TNF‐α mRNA in MTB‐infected by cellular activation ROS was suppressed allicin a dose‐dependent manner. Also, enhanced glutathione peroxidase activity, which correlated inversely downregulation monocytes. Hence, may prove be valuable natural...