A5100769261- Liver Disease Diagnosis and Treatment
- Sepsis Diagnosis and Treatment
- Diet and metabolism studies
- Nutrition and Health in Aging
- Immune cells in cancer
- Neonatal Respiratory Health Research
- High Altitude and Hypoxia
- ECG Monitoring and Analysis
- Membrane Separation Technologies
- Epigenetics and DNA Methylation
- Respiratory Support and Mechanisms
- RNA modifications and cancer
- Thermodynamic properties of mixtures
- Cancer, Hypoxia, and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Ultrasound Imaging and Elastography
- Non-Invasive Vital Sign Monitoring
- Cancer-related gene regulation
- Cardiovascular and Diving-Related Complications
- EEG and Brain-Computer Interfaces
- Orthopaedic implants and arthroplasty
- Cancer-related molecular mechanisms research
- Chemical and Physical Properties in Aqueous Solutions
Guangdong University of Technology
2024
Renmin Hospital of Wuhan University
2022-2024
Wuhan University
2022-2024
Changzhi Medical College
2024
Nankai University
2021-2024
Fudan University
2023-2024
Tianjin People's Hospital
2024
Zhongshan Hospital
2023-2024
Shanghai Chest Hospital
2024
Changhai Hospital
2024
Abstract Intermittent food deprivation (fasting, IF) improves mood and cognition protects neurons against excitotoxic degeneration in animal models of epilepsy Alzheimer’s disease (AD). The mechanisms by which neuronal networks adapt to IF how such adaptations impact neuropathological processes are unknown. We show that hippocampal enhancing GABAergic tone, is associated with reduced anxiety-like behaviors improved hippocampus-dependent memory. These network behavioral require the...
Background and Aim: Hairy enhancer of split-1 (HES1) is a downstream transcriptional factor Notch signaling pathway, which was found to be related chemoresistance. This study aimed investigate the role HES1 in chemoresistance colorectal cancer (CRC). Methods: Tissue microarray used analyze clinical significance radical resected (R0) stage II/III CRC patients that received adjuvant chemotherapy. 5-fluorouracil (5-Fu) examined cell lines (RKO HCT8, LOVO) with stable over-expression inhibition...
Sepsis is a highly heterogeneous syndrome with diverse immune status and varied bioprocesses among individuals. The heterogeneity of sepsis could be associated N6-methyladenosine (m6A) RNA methylation, due to m6A as common reversible posttranscriptional modification involved in the regulation whole bioprocesses. Therefore, we aim identify induced molecular subtypes furthermore explore probable mechanism.Gene expression datasets 479 consecutive patients admitted for intensive care unit (ICU)...
Macrophage polarization has a causal role in the pathogenesis and resolution of various clinical diseases. DNA-binding transcription factors (TFs) have been identified as essential during gene transcription. Better insight into TFs that regulate macrophage could provide novel therapeutic targets. IFN-γ (50 ng/mL) or IL4 (20 was utilized to stimulate bone marrow-derived macrophages from mice for 24 h M1- M2-polarized model construction, respectively. First, ATAC-seq (Assay Targeting...
Background: Growing evidence has demonstrated the important roles of gut microbiota and short chain fatty acids, especially acetate, propionate butyrate, in development obesity metabolic diseases.To date, effects butyrate on human adiposity glucose metabolism remain controversial.This study aimed to explore associations systemically with homeostasis patients type 2 diabetes (T2D) obesity.Methods: A total 12 T2D 8 age-and sex-matched healthy individuals BMI <24 kg/m were enrolled this...
Background and aims To analyze the effect of oral metformin on changes in gut microbiota characteristics metabolite composition normal weight type 2 diabetic patients. Methods T2DM patients cross-sectional study were given for 12 weeks. Patients with unmedicated used as a control group to observe metrics treated regimen. 16S rDNA high-throughput gene sequencing fecal subjects was performed by llumina NovaSeq6000 platform. Targeted macro-metabolomics 14 cases each metabolites using UPLC-MS/MS...
The interrelations between diffusion coefficients and thermodynamic properties in a strongly non-ideal mixture are studied by complementary approaches, considering the interactions methanol cyclohexane.
Abstract Background Despite advances in clinical management, there are currently no novel therapeutic targets for acute respiratory distress syndrome (ARDS). DNA methylation, as a reversible process involved the development and progression of many diseases, would be used potential to improve treatment strategies ARDS. However, meaningful methylation sites associated with ARDS still remain largely unknown. We sought determine difference between patients healthy participants, simultaneously,...
Objective: Powerful adjuvant strategies are required to improve the survival of patients with completely resected stage ΙΙΙA non-small cell lung cancer (NSCLC). We aimed compare efficacy traditional Chinese medicine (TCM) treatment versus observation after chemotherapy in these patients. Methods: Eligible were randomized 1:1 receive either oral decoctions based on Qi-Yin syndrome differentiation (TCM group) or (observation group). The intervention lasted for 12 months. primary endpoint was...
A growing body of evidence suggests that microRNA-494 (miR-494) could act as tumor-suppressive or oncogenic microRNAs (miRNAs) in different types tumors. However, the biological roles and underlying mechanisms miR-494 remain unknown human epithelial ovarian carcinoma (EOC). Therefore, aims this study were to investigate expression significance its clinical diagnosis patients suffering EOC analyze role molecular mechanism on carcinogenesis EOC. Here, we found was significantly decreased cell...
Background: It is much valuable to evaluate the comparative effectiveness of coronavirus disease 2019 (COVID-19) prevention and control in non-pharmacological intervention phase pandemic across countries identify useful experiences that could be generalized worldwide. Methods: In this study, we developed a susceptible–exposure–infectious–asymptomatic–removed (SEIAR) model fit daily reported COVID-19 cases 160 countries. The time-varying reproduction number ( R t ) was estimated through...
RBC-derived nanovesicles are effective hydrophilic drug carriers and can effectively deliver drugs into macrophages both<italic>in vitro</italic>and<italic>in vivo</italic>.
Reminiscence therapy is reported to attenuate the psychological disorders in cancer patients, such as colorectal and lung patients. However, relevant report on surgical prostate patients scarce. This study put forward a reminiscence therapy-based care program (RTCP + UC) combing with usual (UC), aimed evaluate impact of RTCP UC anxiety, depression, quality life survival patients.Totally, 108 receiving resection were enrolled, who subsequently randomized allocated group (N = 55) 53) at 1:1...
Glutamine is characterized as the nutrient required in tumor cells. The study based on glutamine metabolism aimed to develop a new predictive factor for pan-cancer prognostic and therapeutic analyses explore mechanisms underlying development of cancer.The RNA-sequence data retrieved from TCGA, ICGC, GEO, CGGA databases were applied train further validate our signature. Single-cell RNA transcriptome GEO used investigate correlation between cell cycle progression. A series bioinformatics...
The protective effects and antioxidant mechanisms of bamboo leaf flavonoids (BLFs) on hepatocytes injured by CCl4 were studied establishing models hepatocyte damage induced detecting the activities alanine aminotransferase (ALT), aspartate (AST), glutathione peroxidase (GSH-Px), superoxide dismurase (SOD), malondialdehyde (MDA) content liver glycogen content. degree lesions in tissues between model dosage groups was observed through paraffin sections. Results showed that BLFs significantly...