Abstract Background Many adult women younger than 40 years old have premature ovarian failure (POF) and infertility. Previous studies confirmed that different tissue-derived stem cells could restore function folliculogenesis in chemotherapy-induced POF mice. The aim of this study was to explore the therapeutic efficacy underlying mechanisms human amniotic mesenchymal (hAMSCs) transplantation for hydrogen peroxide-induced damage. Methods Bilateral ovaries female mice were burned with 10%...

Lung cancer is the leading cause of cancer-related mortality worldwide due to its early asymptomatic and late metastasis.While stem cells (CSCs) may play a vital role in oncogenesis development lung cancer, mechanisms underlying CSCs self-renewal remain less clear.In present study, we constructed clinically relevant enrichment recognition model evaluated potential functions phosphatidylinositol 3-kinase (PI3K)/AKT pathway (PI3K/AKT) mitogen-activated protein kinases/extracellular...

Myocardial infarction associated transcript (MIAT) is identified as a long chain non-coding RNA (lncRNA), which was with myocardial susceptibility. While intense efforts have been made to elucidate the relationship between MIAT and carcinogenesis, tumor immunoreaction of remains elusive. Thus, this study aimed investigate role in immunoregulation breast cancer (BC) further explore better clinical significance.The differential expression BC normal/adjacent tissues compared using Wilcoxon rank...

RBC-derived nanovesicles are effective hydrophilic drug carriers and can effectively deliver drugs into macrophages both<italic>in vitro</italic>and<italic>in vivo</italic>.

Abstract Bladder cancer (BCa) is one of the most common urinary cancers. The present study aims to investigate whether Paeoniflorin (Pae) can exert inhibitory effects on BCa. results showed that Pae inhibited proliferation human BCa cell lines in a concentration- and time-dependent manner. cisplatin (Cis) synergistically growth tumours RT4-bearing mice. treatment neutralized body loss induced by Cis. Moreover, apoptosis RT4 cells increased activities caspase3, caspase8 caspase9. Western...

Breast cancer (BC) is the leading cause of cancer-related mortality in females and most common malignancy with high morbidity worldwide. It imperative to develop new biomarkers therapeutic targets for early diagnosis effective treatment BC.We revealed oncogene function cadherin 1 (CDH1) via bioinformatic analysis BC. Moreover, miRNA database was utilized predict miRNAs upstream CDH1. Expression CDH1-related BC their values stemness prognosis were analyzed through TCGA-BRCA datasets. In...

Luminal breast cancer (BC) is the predominant subtype of with a sustained risk late recurrence and death. Understanding molecular mechanisms for oncogenesis luminal BC would improve prognosis this large subset patients. SPDEF was reported to be dysregulated in cancers. However, biological functions underlying mechanism remains largely unknown. The aim present study elucidate potential roles subtype-specific BC, especially subtypes.The expressions clinicopathological characteristics patients...

Objective: This article aims to provide a better understanding of ultrasonography and immunohistochemistry secondary nonhematological tumors breast. Methods: The study reviewed the ultrasound findings immunohistochemical features metastatic breast tumor cases found in patients West China Hospital, Sichuan University from 2007 2019. Each case was categorized as malignancy using histopathological results. Results: Fourteen were identified Hospital database. Ten originated lung, 2 stomach, 1...

Gram-positive anaerobic cocci (GPAC) are a commensal part of human flora but also opportunistic pathogens. This is possibly the first study to report case Peptoniphilus harei bacteremia in an abdominal aortic aneurysm (AAA) patient. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) failed identify isolate and molecular analysis confirmed it as P. . A comprehensive literature review revealed that emergent pathogen. serves reminder for practicing...

Abstract Glucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL), a member of the superfamily, is expressed in APCs and acts as costimulatory molecule immune system. Although glucocorticoid-induced receptor-related (GITR)/GITRL system has been modulated to promote or decrease T cell-related responses multiple diseases, studies macrophages are limited. To address this issue, we compared expression GITRL various types analyzed whether can affect fundamental...

Breast cancer (BC) is a molecular diverse disease which becomes the most common malignancy among women worldwide. There are four BC subtypes (Luminal A, Luminal B, HER2-enriched and Basal-like) robustly established following gene expression pattern-based characterization, behave significant differences in terms of their incidence, risk factors, prognosis therapeutic sensitivity. Thus, there an urgent need to provide mechanism research, treatment strategies and/or evaluation based on patient...

Neoadjuvant therapy (NAT) is the preferred treatment for advanced breast cancer nowadays. The early prediction of its responses important personalized treatment. This study aimed at using baseline shear wave elastography (SWE) ultrasound combined with clinical and pathological information to predict response in cancer.This retrospective included 217 patients who were treated West China Hospital Sichuan University from April 2020 June 2022. features ultrasonic images collected according...

(i) To obtain and identify the predatory bacteria for control of contaminated to promote autotrophic growth Chlorella USTB‐01. (ii) measure different cell numbers in microalgal culture using flow cytometer. A bacterial strain was isolated Escherichia coli BL21 as a sole prey host, which identified Bdellovibrio USTB‐06 by analysis 16S rDNA sequence. cytometer successfully used USTB‐01, simultaneously USTB‐01 according identification sizes. With addition at initial 104 plaque‐forming units per...

Resistance to the chemotherapeutic drug cisplatin has been documented in various types of cancer, while increased expression β‑catenin observed cisplatin‑resistant ovarian cancer. However, involvement resistance is unclear. The present study investigated antitumor effect on proliferation, invasion and apoptosis breast cancer (BC) cells following silencing BC, which most frequent type malignancy among women. BC tissues cell lines was measured by reverse transcription‑quantitative polymerase...

Recurrent spontaneous abortion (RSA) is often idiopathic, but structural chromosomal abnormality an important nosogenesis. Balanced translocations or inversions can lead to unbalanced gametes depending on the specific recombination and segregation patterns during meiosis. An karyotype in conceptus of a couple when one partner has may result failure implant, miscarriage, ongoing pregnancy fetus with karyotype.We report two rare Han cases RSA associated balanced translocation chromosomes. In...

Breast cancer (BC) is the leading cause of malignancy death in females worldwide. While intense efforts have been made to elucidate pathogeny, molecular mechanism BC remains elusive. Thus, this study aimed investigate role PPEF1 progression and further explore better clinical significance.The diagnostic prognostic values elevated expression were unveiled via public databases analysis. In addition, Gene Ontology (GO), Set Enrichment Analysis (GSEA) Protein-protein interaction (PPI) analysis...