A5076073231- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Cytokine Signaling Pathways and Interactions
- Bone fractures and treatments
- Software-Defined Networks and 5G
- Immune Cell Function and Interaction
- Galectins and Cancer Biology
- Ear and Head Tumors
- Head and Neck Surgical Oncology
- Birth, Development, and Health
- Total Knee Arthroplasty Outcomes
- Neurogenesis and neuroplasticity mechanisms
- Protease and Inhibitor Mechanisms
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Nuclear Receptors and Signaling
- Salivary Gland Tumors Diagnosis and Treatment
- MicroRNA in disease regulation
- Soft Robotics and Applications
- Management of metastatic bone disease
- Network Security and Intrusion Detection
- Hip and Femur Fractures
- Brain Metastases and Treatment
- S100 Proteins and Annexins
- Viral-associated cancers and disorders
Chinese PLA General Hospital
2020-2024
Shanghai University of Engineering Science
2024
Chinese People's Liberation Army
2021-2023
Chinese People’s Liberation Army 263 hospital
2021-2023
PLA Academy of Military Science
2021-2022
Tianjin Hospital
2013-2021
People's Liberation Army No. 150 Hospital
2021
Shihezi University
2020
Baylor College of Medicine
2020
Shandong Provincial QianFoShan Hospital
2018-2019
We previously identified somatic activating mutations in the KRAS (Kirsten rat sarcoma viral oncogene homologue) gene endothelium of majority human sporadic brain arteriovenous malformations; a disorder characterized by direct connections between arteries and veins. However, whether this genetic abnormality alone is sufficient for lesion formation, as well how active signaling contributes to malformations, remains unknown. To establish first vivo models gain function both mice zebrafish...
Background: Hyperglycaemia promotes the proliferation of cardiac fibroblasts (CFs) and collagen synthesis in CFs. However, molecular mechanism underlying effects HG on CF, is not completely understood. Objectives: The objectives present study were to determine whether STAT proteins has a functional role high glucose-induced CFs vitro signaling pathway MAPK have synergetical glucose-mediated synthesis. Methods: Rat cultured Dulbecco's modified Eagle's medium, supplemented with 5.5 or 25...
To improve the understanding of lymphoma associated hemophagocytic syndrome (LAHS) and find an effective treatment for this fatal disease, 57 patients with LAHS were retrospectively reviewed. The most common histopathological type was extranodal natural killer (NK)/T-cell lymphoma, nasal (ENKL) (45.61%). Patients B-cell significantly older (P<0.001), exhibited a higher triglyceride level (P=0.012), lower serum ferritin (P=0.014) plasma Epstein-Barr virus DNA (P<0.001) compared T/NK-cell...
Regulatory T (Treg) cells are critical suppressors of inflammation and thought to exert mainly deleterious effects in cancers. In colorectal cancer (CRC), Foxp3+ Treg accumulation tumors was associated with poor prognosis. Hence, we examined the circulating CRC patients. Compared controls, patients presented mild upregulations CD4+ CD25+/hi more canonical peripheral blood mononuclear cells. Both these populations could be roughly divided into lymphocyte activation gene 3 negative cell...
Myocardial infarction associated transcript (MIAT) is identified as a long chain non-coding RNA (lncRNA), which was with myocardial susceptibility. While intense efforts have been made to elucidate the relationship between MIAT and carcinogenesis, tumor immunoreaction of remains elusive. Thus, this study aimed investigate role in immunoregulation breast cancer (BC) further explore better clinical significance.The differential expression BC normal/adjacent tissues compared using Wilcoxon rank...
To compare the multimodal techniques (including neuronavigation, intraoperative MRI [iMRI], and neuromonitoring [IONM]) conventional approach (only guided by neuronavigation) in removing glioblastoma (GBM) with corpus callosum (CC) involvement (ccGBM), their effectiveness safety were analyzed compared.Electronic medical records retrospectively reviewed for ccGBM cases treated our hospital between January 2016 July 2020. Patient demographics, tumor characteristics, clinical outcomes, extent...
Spinal cord injuries (SCIs) can induce primary and secondary injury, resulting in severe neurological damage dysfunction patients. Studies have reported that signal transducer activator of transcription 3 (STAT3) plays an important role the inflammatory immune response neural stem cell differentiation. In order to examine whether a STAT3 inhibitor prevent worsening SCI promote differentiation, rat model surgically induced was created rats were treated with S31-201. Tissue from injured region...
Abstract Background Hyperextension bicondylar tibial plateau fracture (HBTPF) is a particular form of which has gained increasing interest recently but were rarely documented. In this study, we reported the characteristics, clinical intervention, and therapeutic outcomes HBTPF patients. Methods From May 2015 to October 2017, data consecutive patients with fractures (BTPF) who underwent surgical treatment in our hospital retrospectively studied. The allocated either group (study group) or...
Abstract The procollagen C-protease enhancer ( PCOLCE ) has been identified to influence tumor growth and metastasis in multiple cancers. However, the relationship between activity progression of gliomas remains largely unknown. Glioma RNA-seq data were derived from Chinese Genome Atlas (CGGA) Cancer databases for analysis. Kaplan–Meier survival curve, clinical characterization correlation, univariate multivariate Cox, receiver operating characteristic curve analyses performed assess...
To investigate the role and mechanism of suppressor cytokine signaling 1 (SOCS1) in regulation differentiation C17.2 neural stem cells (NSCs).In this study, lentiviral (LV)-SOCS1-enhanced green fluorescent protein (EGFP) was constructed transfected into NSCs. There were three groups NSCs: LV-SOCS1-EGFP, LV-EGFP, phosphate-buffered saline (PBS). The expression levels microtubule-associated 2 (MAP2), glial fibrillary acidic (GFAP), myelin basic (MBP), nestin, β-tubulin III NSCs analyzed by...
Purpose: To explore molecular alterations and their correlation with the survival of patients glioblastoma (GBM) corpus callosum (CC) involvement (ccGBM). Methods: Electronic medical records were reviewed for glioma tested treated at our hospital between January 2016 July 2020. ccGBM was compared to GBM without CC (non-ccGBM) identify differences in alterations. Clinical outcomes non-ccGBM patients, as well among different alteration statuses. also diffuse midline (DMG) clarify alterations,...
Abstract Diffuse and multi-lobes involved glioma (DMG) is a rare disease, the aim of this study was to assess role multimodal-assisted surgical resection tumours combined with chemoradiotherapy identify prognosis. Clinical data were collected from 38 patients diagnosis DMG. Nineteen received chemoradiotherapy, another 19 underwent alone after stereotactic puncture biopsy. The clinical characteristics, magnetic resonance imaging (MRI) findings, histopathological diagnosis, progression-free...
Obesity in pregnant women presents a risk to fetal health, leading numerous metabolic syndromes and chronic inflammation risks. Previously, physical exercise was considered be one of the primary treatments for obesity. However, effect fat consumption throughout life cycle on endurance capacity remains unknown. A total two groups female mice (age, 6 weeks; C57BL/6J) were fed with normal chow diet moderate high (MHFD), during pregnancy lactation (8 weeks), offspring receiving same as mother....
Wingless/Int-1 (Wnt) signaling is one of the most well-known oncogenic pathways. Numerous studies have uncovered an aberrant expression Wnt in cancer and its association with multiple processes, such as cell proliferation, epithelial–mesenchymal transition (EMT), invasiveness. Most previous mainly focused on canonical branch pathway, i.e., Wnt/β-catenin signaling. The Wnt/planar polarity (PCP) recently described signaling, was much less investigated oncology research. In this study, we...
Link failures are the most common type of fault in software-defined networking (SDN), which is an extremely crucial aspect SDN tolerance. Existing strategies include proactive and reactive approaches. Proactive schemes pre-deploy backup paths for fast recovery but may exhaust resources, while calculate upon failure, resulting longer better outcomes. This paper proposes a single link failure strategy that combines these two schemes, termed as flow-aware pro-reactive (FAPR), with aim achieving...