A5084012772- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neural Engineering
- Cardiac pacing and defibrillation studies
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Sirtuins and Resveratrol in Medicine
- Adipose Tissue and Metabolism
- Heart Rate Variability and Autonomic Control
- Genetics, Aging, and Longevity in Model Organisms
- Cardiac Arrhythmias and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Birth, Development, and Health
- Biochemical effects in animals
- Heart Failure Treatment and Management
Laboratory Signaling and Cardiovascular Pathophysiology
2021-2022
Université Paris-Saclay
2020-2022
Inserm
2018-2022
Jilin University
2018-2020
Université Paris-Sud
2020
Dysfunction of the sinoatrial node (SAN), natural heart pacemaker, is common in failure (HF) patients. SAN spontaneous activity relies on various ion currents plasma membrane (voltage clock), but intracellular Ca2+ ([Ca2+]i) release via ryanodine receptor 2 (RYR2; clock) plays an important synergetic role. Whereas remodeling voltage-clock components has been revealed HF, less known about possible alterations to clock. Here, we analyzed [Ca2+]i handling from a mouse HF model after transverse...
Cardiovascular complications, including cardiac arrhythmias, result in high morbidity and mortality patients with type-2 diabetes mellitus (T2DM). Clinical experimental data suggest electrophysiological impairment of the natural pacemaker diabetic heart. The present study examined sinoatrial node (SAN) arrhythmias a mouse model T2DM physiologically probed their underlying cause.Electrocardiograms were obtained from conscious db/db lean control db/+ mice. In vivo SAN function was through...
Obesity in pregnant women presents a risk to fetal health, leading numerous metabolic syndromes and chronic inflammation risks. Previously, physical exercise was considered be one of the primary treatments for obesity. However, effect fat consumption throughout life cycle on endurance capacity remains unknown. A total two groups female mice (age, 6 weeks; C57BL/6J) were fed with normal chow diet moderate high (MHFD), during pregnancy lactation (8 weeks), offspring receiving same as mother....
Maize is the food crop with highest total output in world. However, corn bran only a by-product low price. The 5,5′-diferulic acid glucoside esters (DFG) were obtained from using enzymatic method. DFG showed obvious antioxidant capacity cell, Caenorhabditis elegans (C. elegans) and mouse. decreased ROS MDA content 500 μM H2O2 stimulated ARPE-19 cells to 48.6% 32.2%, respectively. C. 49.1% acute ethanol (50%, 12 ml/kg) mouse 30.4%. also increased SOD protein significantly 175.5%, 120.1%,...
Heart failure (HF) is a complex syndrome in which death rates are >50%. The main causes of among HF patients pump and ventricular arrhythmias, but severe bradycardia also common cause sudden cardiac death, pointing to sinoatrial node (SAN) dysfunction. SAN pacemaker activity regulated by voltage-clock Ca2+-clock mechanisms and, although dysfunction has been largely proved HF, remains unraveled. Here, we used an model mice with transverse aortic constriction (TAC) using telemetry, saw slower...
Heart failure (HF) is a complex syndrome in which death rates are over 50%. The main cause of among HF patients pump and ventricular arrhythmias, but severe bradycardia also common sudden cardiac death, pointing to sinoatrial node (SAN) dysfunction. SAN pacemaker activity regulated by voltage-clock Ca2+-clock mechanisms and, although dysfunction has been largely proved HF, remains undiscovered. Here, we used model mice with transverse aortic constriction (TAC) using telemetry saw slower...