A5045139283- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neural Engineering
- ECG Monitoring and Analysis
- Ion channel regulation and function
- Cardiac pacing and defibrillation studies
- Non-Invasive Vital Sign Monitoring
- Heart Rate Variability and Autonomic Control
- 3D Printing in Biomedical Research
- Phonocardiography and Auscultation Techniques
- Optical measurement and interference techniques
- Bone Tissue Engineering Materials
- Cardiac Arrhythmias and Treatments
- Healthcare Technology and Patient Monitoring
- EEG and Brain-Computer Interfaces
- Surface Roughness and Optical Measurements
- Receptor Mechanisms and Signaling
- Industrial Vision Systems and Defect Detection
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
Technion – Israel Institute of Technology
2017-2024
Dysfunction of the sinoatrial node (SAN), natural heart pacemaker, is common in failure (HF) patients. SAN spontaneous activity relies on various ion currents plasma membrane (voltage clock), but intracellular Ca2+ ([Ca2+]i) release via ryanodine receptor 2 (RYR2; clock) plays an important synergetic role. Whereas remodeling voltage-clock components has been revealed HF, less known about possible alterations to clock. Here, we analyzed [Ca2+]i handling from a mouse HF model after transverse...
The combined influences of sinoatrial nodal (SAN) pacemaker cell automaticity and its response to autonomic input determine the heart's beating interval variability mean rate. To intrinsic SAN signatures buried within EKG RR time series change in advanced age, we measured before during double blockade at 3-month intervals from 6 months age until end life long-lived (those that achieved total cohort median span 24 beyond) C57/BL6 mice. Prior 21 time-dependent changes were relatively minor....
Bradycardia or tachycardia are known side effects of drugs that limit their clinical use. The heart pacemaker function which control the rate under normal conditions is determined by coupled clock system. Thus, interfering with specific mechanism will affect other mechanisms through changes in interconnected signaling and can lead to rhythm disturbance. However, upregulation a different components compensate for this change. We focus here on hydroxychloroquine (HCQ), has been shown effective...
Culturing atrial cells leads to a loss in their ability be externally paced at physiological rates and maintain shape. We aim develop culture method that sustains the shape of along with biophysical bioenergetic properties response pacing. hypothesize adding 2,3-Butanedione 2-monoxime (BDM), which inhibits contraction during period, will preserve these properties. Rabbit were maintained for 24h medium enriched myofilament inhibitor, BDM. The morphology volume cells, including contract 1-3 Hz...
Background The interactions between the autonomic nervous system (ANS), intrinsic systems (e.g., endocrine), and internal pacemaker mechanisms govern short (milliseconds–seconds)- long (seconds–minutes)-range heart rate variability (HRV). However, there is a debate regarding identity of mechanism underlying HRV on each time scale. We aim to design general method that accurately differentiates relative contribution ANS in various mammals, without need for drug perturbations or organ...
Abstract The standard polygraph, or lie detector, is limited by its reliance on average heart rate, subjective examiner interpretation, and the need for direct subject contact. Remote photoplethysmography (rPPG) offers a promising contactless alternative, using facial videos to extract rate variability (HRV). We introduce "LieRHRV," remote detection algorithm based solely extracted HRV parameters. To test parameter quality, we compared these parameters from ECG (PPG) records archived in five...
Heart failure (HF) is a complex syndrome in which death rates are >50%. The main causes of among HF patients pump and ventricular arrhythmias, but severe bradycardia also common cause sudden cardiac death, pointing to sinoatrial node (SAN) dysfunction. SAN pacemaker activity regulated by voltage-clock Ca2+-clock mechanisms and, although dysfunction has been largely proved HF, remains unraveled. Here, we used an model mice with transverse aortic constriction (TAC) using telemetry, saw slower...
In this paper, we present a new approach for analyzing white light speckle patterns. The paper introduces an analytic model and heuristic explanations the phenomena using contrast intensity statistics of speckles. Relations between coherence length, central wavelength surface roughness are examined. It is shown that directly related to autocorrelation function. We show consistent with previous models simulation results experimental data.
Bradycardia is initiated by the sinoatrial node (SAN), which regulated a coupled-clock system. Due to clock coupling, reduction in 'funny' current (If), affects SAN automaticity, can be compensated, thus preventing severe bradycardia. We hypothesize that this fail-safe system an inherent feature of pacemaker cells and driven synergy between If other ion channels. This work aimed characterize connection membrane currents their underlying mechanisms cells. tissues were isolated from C57BL mice...
Abstract SAN failure, aka sick-sinus syndrome, which features sinus bradycardia, impulse pauses, and irregularity of RR interval rhythms are manifestations cell dysfunction that increases exponentially with advanced age, i.e., frailty. Abnormalities in intrinsic variability may be the earliest signatures leading to frailty late life. We measured within EKG timeseries prior during double autonomic blockade long-lived C57/BL6 mice at 3 month intervals from 6 months age until end Long-lived...
Heart failure (HF) is a complex syndrome in which death rates are over 50%. The main cause of among HF patients pump and ventricular arrhythmias, but severe bradycardia also common sudden cardiac death, pointing to sinoatrial node (SAN) dysfunction. SAN pacemaker activity regulated by voltage-clock Ca2+-clock mechanisms and, although dysfunction has been largely proved HF, remains undiscovered. Here, we used model mice with transverse aortic constriction (TAC) using telemetry saw slower...