A5001381852- Hippo pathway signaling and YAP/TAZ
- Nanoplatforms for cancer theranostics
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Wnt/β-catenin signaling in development and cancer
- Ubiquitin and proteasome pathways
- Genetics, Aging, and Longevity in Model Organisms
- Neurobiology and Insect Physiology Research
- Cancer-related gene regulation
- Extracellular vesicles in disease
- FOXO transcription factor regulation
- Autophagy in Disease and Therapy
- RNA Interference and Gene Delivery
- Phytochemicals and Antioxidant Activities
- Invertebrate Immune Response Mechanisms
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Nanoparticle-Based Drug Delivery
- Cancer Mechanisms and Therapy
- Circular RNAs in diseases
- Cell death mechanisms and regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Heat shock proteins research
- Histone Deacetylase Inhibitors Research
First Hospital of Jilin University
2017-2025
Jilin University
2017-2025
North China University of Science and Technology
2016-2025
Jiangxi Agricultural University
2025
Wuxi People's Hospital
2023-2025
Nanjing Medical University
2023-2025
Tianjin haihe hospital
2025
Tianjin University of Traditional Chinese Medicine
2025
Second Affiliated Hospital of Nanjing Medical University
2024
Shandong University of Traditional Chinese Medicine
2024
Background Glioblastoma multiforme (GBM) is the most common cancer of central nervous system, while Parkinson’s disease (PD) a degenerative neurological condition frequently affecting elderly. Neurotrophic factors are key associated with progression neuropathies and gliomas. Methods The 2601 neurotrophic factor-related genes (NFRGs) available in Genecards portal were analyzed 12 NFRGs potential roles pathogenesis prognosis GBM identified. LASSO regression random forest algorithms then used...
Herein, we for the first time report a novel activatable photoacoustic (PA) imaging nano-probe in vivo detection of cancer-related matrix metalloproteinases (MMPs). A black hole quencher 3 (BHQ3) which absorbs red light is conjugated to near-infrared (NIR)-absorbing copper sulfide (CuS) nanoparticles via MMP-cleavable peptide linker. The obtained CuS-peptide-BHQ3 (CPQ) exhibits two distinctive absorption peaks at 630 nm and 930 nm. Inside tumor microenvironment where MMPs present,...
Abstract Background Circular RNA (circRNA) and N6‐methyladenosine (m6A) play a critical role in tumour occurrence development, including colorectal cancer (CRC). However, little is known about the interaction between circRNA m6A radiosensitivity of CRC. Here, we investigated novel m6A‐regulated Methods Differentially expressed circRNAs from radiosensitive radioresistant CRC tissues were screened. Modifications selected examined by methylated immunoprecipitation assay. Finally, subjected to...
Acute traumatic brain injury (TBI) is associated with long-term cognitive and behavioral dysfunction. In vivo studies have shown histone deacetylase inhibitors (HDACis) to be neuroprotective following TBI in rodent models. HDACis are intriguing candidates because they capable of provoking widespread genetic changes modulation protein function. By using known a unique small-molecule pan-HDACi (LB-205), we investigated the effects mechanisms HDACi-induced neuroprotection CNS an astrocyte...
CCR9+ T cells have an increased potential to be activated and therefore may mediate strong antitumor responses. Here, we found, however, that CCL25, the only chemokine for cells, is not expressed in human or murine triple-negative breast cancers (TNBCs), raising a hypothesis intratumoral delivery of CCL25 enhance immunotherapy TNBCs. We first determined whether this approach can CD47-targeted using tumor acidity-responsive nanoparticle system (NP-siCD47/CCL25) sequentially release protein...
Signalling networks that control the life or death of a cell are central interest in modern biology. While defined roles c-Jun N-terminal kinase (JNK) pathway regulating have been well-established, additional factors modulate JNK-mediated yet to be fully elucidated. To identify novel regulators JNK-dependent death, we performed dominant-modifier screen Drosophila and found Toll participates death. Loss signalling suppresses ectopically physiologically activated JNK signalling-induced Our...
// Shiyi Yu 1,* , Xiuxiu Cai Chenxi Wu 1 Lele ,Yuzhi Wang Yan Liu Zhenghong 2 Sheng Qin 3 Fei Ma Jean Paul Thiery 4,5,6 and Liming Chen The Key Laboratory of Developmental Genes Human Disease, Ministry Education, Institute Life Science, Southeast University, Nanjing, P.R. China Department Medical Oncology, Jinling Hospital, for Comparative Genomics Bioinformatics & Jiangsu Biodiversity Biotechnology, College Nanjing Normal 4 Cancer Science Institute, National University Singapore, Singapore...
Breast cancer is the leading cause of women death.Heat shock protein 90 (HSP90) and Histone deacetylase 6 (HDAC6) are promising anti-cancer drug targets.However, it's still unclear applicability anti-HSP90 anti-HDAC6 strategies in precision treatment breast cancer.In current study, we found that triple negative (TNBC) cells, compared to T47D, an ERα+ cell line, exhibited 7~40 times lower IC 50 values, stronger cycle perturbation, increased apoptosis inhibition migration upon 17-DMAG...
Type-2 diabetes mellitus (T2DM) is mainly characterized by insulin resistance (IR) induced hyperglycaemia and insufficient secretion. We employed a diabetic fly model to examine the effect molecular mechanism of Atractylodes macrocephala Koidz. Cuscuta chinensis Lam. (AMK–CCL) extract as traditional Chinese medicine in treating IR T2DM. The contents active ingredients (rhamnose, xylose, mannose, hyperoside) AMK–CCL were determined high-performance liquid chromatography. Wild-type (Cg-GAL4/+)...
Tumor heterogeneity is a common hallmark of cancer and considered major cause treatment failure relapse, yet it remains poorly understood how various types cells communicate within the tumor microenvironment to regulate progression in vivo. Here we establish novel model eye epithelium Drosophila melanogaster dissect vivo mechanisms underlying intercellular communication by combining sophisticated genetic techniques with single-cell RNA sequencing (scRNA-seq). Our results demonstrate that...
Metastasis is the primary cause of death in patients with malignant tumors. Therefore, effectively controlling or reversing tumor cell growth and metastasis crucial for treating In this study, we investigated effects underlying mechanisms Binpu-3 (a strain Taraxacum sinicum Kitag., which was cultivated slightly saline-alkali soil) on invasion both Drosophila human breast cancer cells. High-performance liquid chromatography (HPLC) analysis revealed that caftaric, chlorogenic, caffeic,...
Objective: To explore mechanisms of Modified Tongyou Decoction (MTD) and its separated formulas inhibiting vasculogenic mimicry (VM) in esophageal cancer (EC) TE-1 cells improving the hypoxic environment via NF-κB/HIF-1α axis on basis hypoxia stimulating cells’ VM formation. Methods: The extract MTD was prepared by water extraction alcohol precipitation-whirl evaporation, amygdalin, content antitumor active component, determined chromatography. were divided into normoxia control (NC) group,...
Immunotherapy has shown promising results in multiple malignancies. However, there are still significant challenges cancer immunotherapy including the powerful immunosuppressive tumor microenvironment and adverse off-target side effects. Nanomaterials with defined physico-biochemical properties versatile drug delivery platforms that may address these key technical faced by immunotherapy. Here, a acidity-responsive biomacromolecule system was designed to intratumorally deliver an...
SignificanceUnderstanding autophagy regulation is instrumental in developing therapeutic interventions for autophagy-associated disease. Here, we identified SNAI2 as a regulator of from genome-wide screen HeLa cells. Upon energy stress, transcriptionally activated by FOXO3 and interacts with to form feed-forward regulatory loop reinforce the expression genes. Of note, SNAI2-increased FOXO3-DNA binding abrogates CRM1-dependent nuclear export, illuminating pivotal role DNA retention...
Abstract The interaction between tumor cells and stromal within the microenvironment plays a critical role in cancer progression. Mesenchymal stem (MSCs) are important that exhibit pro-oncogenic activities when reprogrammed by tumor. However, precise mechanisms underlying MSC reprogramming gastric remain not well understood. QRT-PCR, western blot, immunohistochemistry were used to examine gene protein expression levels. In vitro vivo experiments conducted assess biological functions of...
Background: In the past decade, immunotherapy has become a major choice for treatment of lung cancer, yet its therapeutic efficacy is still relatively limited due to various immune escape mechanisms tumors. Based on this, we introduce Neo-BCV, novel bacterial composite vaccine designed enhance responses against cancer. Methods: We investigated enhancing effect Neo-BCV through in vivo and vitro experiments, including flow cytometry, RNA-seq, Western blot. Results: have demonstrated that can...
Apoptosis plays pivotal roles in organ development and tissue homeostasis, with its major function to remove unhealthy cells that may compromise the fitness of organism. Toll signaling, ancient evolutionary origin, regulates embryonic dorsal-ventral patterning, axon targeting degeneration, innate immunity. Using Drosophila as a genetic model, we characterized role signaling apoptotic cell death.We found gain is able trigger caspase-dependent death development. In addition, JNK activity...