A5100427752- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Metabolism, Diabetes, and Cancer
- Blood Pressure and Hypertension Studies
- Gut microbiota and health
- MicroRNA in disease regulation
- Growth Hormone and Insulin-like Growth Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Sinusitis and nasal conditions
- Cancer-related gene regulation
- Cancer Research and Treatments
- Asthma and respiratory diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Inflammasome and immune disorders
- Genetic Associations and Epidemiology
- Hemoglobinopathies and Related Disorders
- PI3K/AKT/mTOR signaling in cancer
- Heat shock proteins research
- Nasal Surgery and Airway Studies
- RNA Research and Splicing
- Phosphodiesterase function and regulation
- Thyroid Disorders and Treatments
- Cardiac Health and Mental Health
- Erythrocyte Function and Pathophysiology
Shantou University
2018-2025
Second Affiliated Hospital of Shantou University Medical College
2025
Zhuhai People's Hospital
2024
Jinan University
2024
Sixth Affiliated Hospital of Sun Yat-sen University
2017-2024
Sun Yat-sen University
2017-2024
Guangdong Provincial People's Hospital
2024
University of Groningen
2022-2023
University Medical Center Groningen
2022-2023
Shantou University Medical College
2018-2023
Overexpression of α-synuclein (SNCA) in families with multiplication mutations causes parkinsonism and subsequent dementia, characterized by diffuse Lewy Body disease post-mortem. Genetic variability SNCA contributes to risk idiopathic Parkinson's (PD), possibly as a result overexpression. downregulation is therefore valid therapeutic target for PD. We have identified human murine-specific siRNA molecules which reduce vitro. As proof concept, we demonstrate that direct infusion chemically...
Background and Aim: Hairy enhancer of split-1 (HES1) is a downstream transcriptional factor Notch signaling pathway, which was found to be related chemoresistance. This study aimed investigate the role HES1 in chemoresistance colorectal cancer (CRC). Methods: Tissue microarray used analyze clinical significance radical resected (R0) stage II/III CRC patients that received adjuvant chemotherapy. 5-fluorouracil (5-Fu) examined cell lines (RKO HCT8, LOVO) with stable over-expression inhibition...
Genome-wide association studies (GWASs) have shown that genetic variants are important determinants of free fatty acid levels. The mechanisms underlying the associations between and levels incompletely understood. Here, we aimed to identify markers could influence diverse in a Chinese population uncover molecular terms DNA methylation gene expression. We identified strong single-nucleotide polymorphisms (SNPs) desaturase (FADS) region multiple polyunsaturated acids. Expression quantitative...
Objective: This study aimed to investigate the gut microbiome profile in different inflammatory phenotypes of treatment-naive newly diagnosed asthmatic adults, gain insight on associations between intestinal microbiota and phenotypic features that characterize asthma heterogeneity develop new treatments for asthma. Methods: Fresh stool samples were obtained from 20 healthy subjects 47 patients prior any interventions. The asthmatics divided into allergic non-allergic cohorts. Intestinal was...
Abstract Aim Previous reports found positive associations between RBC traits (RBC count and hemoglobin) hypertension, but their individual joint effects on new-onset hypertension by sex are unclear. Methods This longitudinal study involved 51,663 adults from the Kailuan Cohort. We utilized weighted Cox regression models to evaluate of hemoglobin sex. Restricted cubic splines Kaplan-Meier curves were employed nonlinear relationships depict differential survival probabilities, respectively....
Neuregulin 4 (Nrg4), an adipose tissue–enriched endocrine factor, participates in adipocyte-to-hepatocyte communication, eliciting beneficial metabolic effects nonalcoholic fatty liver disease (NAFLD). We evaluate the physiological roles of NRG4 humans and unravel role variants pathogenesis NAFLD related disorders. identified two rare missense mutations—p.R44H p.E47Q—in EGF-like domain by whole-exome sequencing 224 severely obese subjects exome genotyping 2,388 from Shanghai Obesity Study....
8516 Background: Small cell lung cancer (SCLC) tends to progress rapidly on first-line therapies, with limited subsequent-line treatment options. Methods: In this single-arm objective performance trial, adult patients extensive-disease SCLC (ED-SCLC) received intravenous sintilimab 200 mg day 1 and oral anlotinib 12 days 1-14. Treatment lasted for 3 weeks per cycle was continued until disease progression, unacceptable toxicities, or death. The primary endpoint the superiority of...
Objective Early screening of non‐alcoholic fatty liver disease (NAFLD) is great significance for the early detection and intervention in NAFLD. MicroRNAs (miRNAs) are important regulators metabolic diseases including The aim this study was to investigate association serum miR‐29a‐c with NAFLD a Chinese population. Methods Participants were divided into four groups based on presence or absence and/or type 2 diabetes mellitus (T2DM). Quantitative polymerase chain reaction analysis performed...
Abstract Background Non-invasive diagnostic markers are of great importance for early screening nonalcoholic fatty liver disease (NAFLD). MicroRNAs (miRNAs) play significant roles in many metabolic disease, including NAFLD. Therefore, this study focusd on a Chinese population to explore the possible correlation between circulating miR-132 and Results Serum was positively associated with NAFLD non-type 2 diabetes mellitus (T2DM) groups by logistic regression (OR = 3.082 [1.057, 8.988], P...
Despite increasing interest in growth differentiation factor 11 (GDF11) based on its involvement age-related disorders, clinical implications - especially for metabolic diseases remain unclear. Therefore, we assessed the association between serum GDF11 levels and disturbance Chinese population.
Platelet count has been associated with blood pressure, but whether this association reflects causality remains unclear. To strengthen the evidence, we conducted a traditional observational analysis in Lifelines Cohort Study (n = 167,785), and performed bi-directional Mendelian randomization (MR) summary GWAS data from UK Biobank 350,475) International Consortium of Blood Pressure (ICBP) 299,024). Observational analyses showed positive associations between platelet pressure (OR 1.12 per SD,...
Previous studies have found associations of red blood cell (RBC) traits (hemoglobin and RBC count) with pressure; whether these are causal is unknown.We performed cross-sectional analyses in the Lifelines Cohort Study (n = 167,785). Additionally, we bidirectional 2 sample Mendelian randomization (MR) to explore effect on systolic (SBP) diastolic pressure (DBP), using genetic instrumental variables regarding hemoglobin identified UK Biobank 350,475) International Consortium Blood Pressure for...
Spermatogenesis is a complex cellular-differentiation process that relies on the precise regulation of gene expression in spermatogonia, meiotic, and postmeiotic germ cells. The Ring 1 YY1 binding protein (Rybp) member mammalian polycomb-group (PcG) family plays multifunctional roles development. Previous findings indicate Rybp may function as an important regulator meiosis. However, its testes spermatogenesis have not been examined. In this study, we investigated postnatal mouse using...
Hepatocellular carcinoma (HCC) is the most common type of liver cancer, accounting for ~90% total cases. DnaJ heat shock protein family member C8 (DNAJC8), belonging to 40 (HSP40) family, known regulate cancer biology function. However, role DNAJC8 on HCC development remains unknown.
Abstract Interpretation: Our findings enhance the understanding of causal link between PAH and ten major mental illnesses, firmly establishing as a distinct risk factor for MDD. Furthermore, our study highlights potential pivotal role SESTD1 in this pathophysiological process, offering valuable insights drug intervention targets. Background: Evidence from clinical studies suggests that pulmonary arterial hypertension (PAH) is associated with psychiatric disorders. However, association...
The intricate interplay of interleukin-10 (IL-10) and gut microbiota influences tumor development progression, yet the impacts on colorectal cancer (CRC) metastasis remain incompletely understood. impact Il10 deficiency CRC was first evaluated in samples mouse model. Antibiotic sterilization fecal transplantation (FMT) experiment were used to assess role IL-10 mediated metastasis, full-length 16S rDNA sequencing analysis further identified potential target bacteria influencing metastasis....
Background It is unclear how cardiac autonomic function, as indicated by heart rate (HR), variability (HRV), HR increase during exercise, and recovery after related to blood pressure (BP). We aimed examine the observational genetic evidence for a potential causal effect of these HR(V) traits on BP. Methods performed multivariable adjusted linear regression using Lifelines UK Biobank cohorts investigate relationship between Linkage disequilibrium score was conducted correlations. used...
Objective Previous studies have shown negative associations between total bilirubin (TBIL) and hypertension. However, the association of TBIL with new-onset hypertension in perimenopausal women is unknown. Methods A 196 were included this cross-sectional study which 85 had All participants underwent 24-hour ambulatory blood pressure monitoring a clinical assessment including anthropometrics. Sociodemographic, lifestyle, menopausal symptoms (modified Kupperman Index [mKI]) measured by...