A5101545112- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Research and Treatments
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Gut microbiota and health
- Esophageal Cancer Research and Treatment
- Immunotherapy and Immune Responses
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- Lung Cancer Treatments and Mutations
- Ion Transport and Channel Regulation
- RNA Research and Splicing
- Metabolism, Diabetes, and Cancer
- Natural product bioactivities and synthesis
- Colorectal Cancer Treatments and Studies
- Cancer Cells and Metastasis
- Cancer Mechanisms and Therapy
- Hippo pathway signaling and YAP/TAZ
- Membrane-based Ion Separation Techniques
- Wnt/β-catenin signaling in development and cancer
Changzhi Medical College
2023-2024
Huazhong University of Science and Technology
2023
Union Hospital
2023
Union Hospital
2023
First Affiliated Hospital of Zhengzhou University
2008-2022
Shanghai Cell Therapy Research Institute
2021
Children's Hospital of Zhejiang University
2020
Hubei University of Medicine
2018-2019
The University of Texas MD Anderson Cancer Center
2018
The University of Texas Health Science Center at Houston
2018
Epithelial–mesenchymal transition (EMT) is a key process in the tumor metastatic cascade that characterized by loss of cell–cell junctions and cell polarity, resulting acquisition migratory invasive properties. Recent evidence showed altered microRNA-10b (miR-10b) expression was implicated occurrence EMT breast cancer. However, exact role underlying mechanisms miR-10b cancer still remain unknown. In this study, found to be upregulated tissues lines shown closely correlated with...
Epithelial ovarian cancer (EOC) is the leading cause of death among gynecological malignancies in China. In particular, advanced/refractory lacks effective targeted therapies due to immunosuppressive and proangiogenic tumor microenvironment. Mesothelin (MSLN) has been found be highly expressive most EOC. Targeting MSLN by antibodies or chimeric antigen receptor-modified T (CAR-T) cells immune checkpoint blockades as well apatinib, an anti-angiogenic drug, have used patients with refractory...
Abstract The Hippo signaling axis is a tumor suppressor pathway that activated by various extra‐pathway factors to regulate cell differentiation and organ development. Recent studies have reported autophosphorylation of the core kinase cassette stimulates activation cascade. Here, we demonstrate protein arginine methyltransferase 5 (PRMT5) contributes inactivation in pancreatic cancer. We show initiator serine/threonine 3 (STK3, also known as MST2) can be symmetrically di‐methylated PRMT5 at...
Background and aims To analyze the effect of oral metformin on changes in gut microbiota characteristics metabolite composition normal weight type 2 diabetic patients. Methods T2DM patients cross-sectional study were given for 12 weeks. Patients with unmedicated used as a control group to observe metrics treated regimen. 16S rDNA high-throughput gene sequencing fecal subjects was performed by llumina NovaSeq6000 platform. Targeted macro-metabolomics 14 cases each metabolites using UPLC-MS/MS...
microRNAs (miRNAs) have been suggested to play a vital role in regulating tumor progression and invasion. However, the expression of miR-27a esophageal squamous cell carcinoma (ESCC) its effect on tumorigenesis ESCC are unclear. In present study, we found that was downregulated lines specimens with lymph node metastasis. Furthermore, demonstrated binds 3'-untranslated region (UTR) KRAS inhibits protein. levels were inversely correlated mRNA protein specimens. Both vitro vivo assays revealed...
Aim Esophageal squamous cell carcinoma (ESCC) is one of the most common fatal malignances digestive tract. Its prognosis poor mainly due to lack reliable markers for early detection and prognostic prediction. Here we aim identify molecules involved in ESCC carcinogenesis those as potential new molecular therapeutic targets. Methods We performed genome-wide gene expression profile analyses 10 primary ESCCs their adjacent normal tissues by cDNA microarrays representing 47,000 transcripts...
Abstract miR‐516a‐3p has been reported to play a suppressive role in several types of human tumours. However, the expression level, biological function and fundamental mechanisms breast cancer remain unclear. In present study, we found that was down‐regulated Pygopus2 (Pygo2) up‐regulated tissues cells. Through analysing clinicopathological characteristics, demonstrated low or positive Pygo2 predictor poor prognosis for patients with cancer. The results dual luciferase reporter assay Western...
Oxidative stress and autophagy are the key promoters of calcium oxalate (CaOx) nephrolithiasis. Taurine is an antioxidant that plays a protective role in pathogenesis kidney disease. Previous studies found taurine suppressed cellular oxidative stress, inhibited activation. However, effect on CaOx stone formation remains unknown. In present work, we explored regulatory effects crystals-induced HK-2 cell injury. Results showed pretreatment with significantly enhanced viability cells...
Previous studies from our laboratory have demonstrated that the intermediate phenotype of thermosensitivity is present in hypertensive mice and rats. Increased expression hsp70 caused by increased transcription rate was vivo, organs, cultured cells spontaneously rats mice. In this study, a polymorphism gene revealed with BamHI enzyme using human probe. A 4.4-kb fragment visualized normotensive (Brown-Norway BN.lx Sprague-Dawley), 3.0-kb found (SHR) three different origins Wistar Buffalo Both...
Long noncoding RNAs (lncRNAs) are emerging as key molecules in human cancer. In the present study, we explored role of lncRNA PANDAR colorectal cancer (CRC).The relative expression level CRC tissues and cell lines was determined by quantitative real-time polymerase chain reaction (qRT-PCR). The associations between clinicopathological features patients were further analyzed. Kaplan-Meier survival analysis performed to evaluate value prognosis patients. Furthermore, biological function on...
The endothelial lipase gene (LIPG) is one of the important genes in metabolism high-density lipoprotein cholesterol (HDL-C) and may be involved pathogenesis coronary artery disease (CAD).To investigate relationship between common single nucleotide polymorphisms (SNPs) 584C/T (rs2000813) -384A/C (rs3813082) LIPG CAD, allele genotype frequencies two SNPs were analysed 287 Chinese patients with CAD 367 controls by high-resolution melting curve (HRM) method.For 584C/T, no significant difference...
Long non-coding RNAs (lncRNAs) are non-protein-coding longer than 200 nucleotides. Accumulating evidence demonstrate that lncRNA potential biomarkers for cancer diagnosis and prognosis. However, there no prognostic models multiple myeloma (MM). Hence, it is necessary to screen novel can potentially participate in the initiation progression of MM consequently construct a risk score system disease. Raw microarray datasets were obtained from Gene Expression Omnibus (GEO) website. Weighted gene...
Apatinib, a highly selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2), inhibits the angiogenesis tumours. The function and mechanism apatinib in oesophageal squamous cell carcinoma (ESCC) remain unknown. In present study, we found that development ESCC patients was controlled by treatment combination chemotherapeutic drug. Moreover, efficiently promotes apoptosis, proliferation, invasion, epithelial-mesenchymal transition (EMT) activity Akt/mTOR pathway cells....
Bladder cancer is the second most common urological malignancy around world and by far frequent in China. The abnormal expression of sphingosine kinase 2 (SphK2) associated with tumor progression a poor patient survival rate, however, effect SphK2 on bladder cells remains unclear. aim paper was to study role cell proliferation, metastasis, apoptosis vitro. Our results showed that up-regulated tissues compared corresponding adjacent non-neoplastic tissues, level significantly higher human...