A5040030545- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Peptidase Inhibition and Analysis
- Systemic Lupus Erythematosus Research
- Protease and Inhibitor Mechanisms
- Ferroptosis and cancer prognosis
- Liver Diseases and Immunity
- Liver physiology and pathology
- HIV/AIDS drug development and treatment
- Meta-analysis and systematic reviews
- Cancer Treatment and Pharmacology
- Blood groups and transfusion
- Cancer Immunotherapy and Biomarkers
- MRI in cancer diagnosis
- Organ Transplantation Techniques and Outcomes
- Cancer, Hypoxia, and Metabolism
- Alcohol Consumption and Health Effects
- Renal cell carcinoma treatment
Kaohsiung Chang Gung Memorial Hospital
2015-2024
Chang Gung University
2015-2024
Kaohsiung Medical University
2024
University of Michigan
2024
University of California, Davis
2024
Memorial Hospital of South Bend
2013-2022
Center for HIV and Hepatogastroenterology
2019
National Cheng Kung University
2017
National Cheng Kung University Hospital
2017
National Yang Ming Chiao Tung University
2016
Antiviral therapy can prevent the development of hepatocellular carcinoma (HCC) in chronic hepatitis C (CHC) patients. However, HCC still develops patients achieving sustained virological response (SVR). We proposed to evaluate risk factors and derive a novel score for (scoreHCC) by summation products clinical weights based on regression coefficients final proportional hazards model. From March 2002 October 2009, we enrolled 871 with biopsy-proven CHC, who received combined pegylated...
Hepatocarcinogenesis is a multistep process that evolves from cirrhosis or dysplastic nodule (DN), and eventually leads to overt hepatocellular carcinoma (HCC). Differentiation between early HCC DN an important issue in the clinical setting. This study aims investigate potential of circulating microRNA (miRNA) levels diagnosis HCC. RNA was extracted sera 30 chronic hepatitis B patients with pathologically proven 120 age- sex-matched Paired samples were collected ten who developed follow-up....
OBJECTIVES: To compare the efficacy of hepatocellular carcinoma (HCC) surveillance at 4- and 12-month intervals in a community for patients with chronic viral hepatitis thrombocytopenia. METHODS: In 10 townships, adults (≥40 years) platelet ≤150 (×109)/l, positive B surface antigen, or antibody to C virus were invited this study. These townships randomized into (group A) B) interval groups. Seven hundred eighty-five 796 residents met study criteria groups A B. Ultrasonography (US) was...
Background and aim The aspartate aminotransferase (AST)-to-platelet ratio index (APRI) fibrosis-4 (FIB-4) are commonly used compound surrogates for advanced fibrosis in chronic hepatitis C (CHC) patients. However, the use of APRI FIB-4 entails a risk overestimating stage due to impact necroinflammatory activity on transaminases. We sought investigate optimal cutoff values two predicting cirrhosis stratified by AST level. Methods This retrospective study enrolled 1716 treatment-naive CHC...
Background & AimsPolymorphisms in interferon (IFN)L3 (encodes IFNλ3 or interleukin 28B) are associated with outcomes of treatment for hepatitis C virus (HCV) infection. However, there is controversy regarding how polymorphisms IFNL3 affect the risk development hepatocellular carcinoma (HCC) patients treated pegylated and ribavirin.MethodsIn a retrospective study, we analyzed data from 1118 HCV infection (589 men; median age, 60 y; 49.9% infected genotype 1; 51.3% advanced fibrosis) ribavirin...
Background/Aims A recent study from the United States reported that nearly 12% of hepatocellular carcinomas (HCCs) occurred in patients without cirrhosis. Non-alcoholic fatty liver disease (NAFLD) was most common these patients. We aim to evaluate characteristics, etiologies, and outcomes cases non‐cirrhotic HCC East Asia, where there is a higher prevalence hepatitis B virus (HBV)-associated non-cirrhotic HCC. Methods This retrospective consecutively enrolled de novo managed at our...
We evaluated whether combining the radiographic tumor burden score (TBS) and alpha-fetoprotein (AFP) level could be used to stratify overall survival (OS) among hepatocellular carcinoma (HCC) patients after liver resection (LR). Patients who underwent LR for Barcelona Clinic Liver Cancer stage 0, A, or B HCC between 2011 2018 were enrolled. TBS scores calculated using following equation: TBS2 = (largest size (in cm))2 + (tumor number)2. Among 743 patients, 193 (26.0%) had a low (<2.6),...
Abstract Background & Aims Patients with chronic hepatitis C (CHC) after successful antiviral therapy remain at risk of hepatocellular carcinoma (HCC). This study was to determine whether liver stiffness measurement (LSM) useful in HCC assessment and develop a risk‐score system for clinical use. Methods retrospective enrolled patients CHC achieving sustained virological response (SVR) interferon‐based LSM at/after SVR determination. The demographics, characteristics development were...
Our objective was to develop a predictive nomogram that could estimate the long-term survival of patients with very early/early-stage hepatocellular carcinoma (HCC) undergoing radiofrequency ablation (RFA). For this retrospective study, we enrolled 950 who initially received curative RFA for HCC at Barcelona Clinic Liver Cancer (BCLC) stages 0 and A between 2002 2016. Factors predicting poor after were investigated through Cox proportional hazard model. The constructed using variables...
We aimed to investigate the natural course of hepatic focal nodular hyperplasia (FNH) in a long-term follow-up study with sonography.This comprised 30 patients (24 women and 6 men) 34 FNHs. Diagnosis FNH was made using color Doppler sonography, contrast-enhanced CT, or MRI combination needle biopsy. Patients were followed every 3 months sonography. Regression progression tumor defined as change over 30% maximal diameter. Disappearance no vizualization on at least sonographic...
Metabolic risk factors are associated with liver fibrosis. Whether or not metabolic affect the severity of fibrosis in patients chronic hepatitis B (CHB), C (CHC), non-alcoholic fatty disease (NAFLD) remains unclear. We aimed to investigate this by transient elastography.In cross-sectional study, we enrolled 1513 who presented (CLD) at a tertiary hospital. Liver stiffness measurement (LSM) >13 kPa was used as cutoff suggesting possible cirrhosis (LC).Possible LC noted 7.8% CHB patients,...
Lenvatinib is approved for patients with advanced hepatocellular carcinoma (HCC) due to its non-inferiority sorafenib of overall survival (OR) in clinical trials. This study was compare the effectiveness and safety lenvatinib real world.We retrospectively evaluated 338 unresectable HCC who had undergone or treatment between January 2018 August 2020. Propensity-score matching analysis performed a 1:2 ratio reduce real-life baseline difference two groups.A total 210 (Male/Female: 150/60, mean...
This study was conducted to determine whether the causes of death among patients with hepatocellular carcinoma (HCC) differ according chronic liver disease (CLD) etiology. Between 2011 and 2020, 3977 who were newly diagnosed HCC at our institution enrolled in this study. We determined cause HCC-related non-HCC-related. For multiple CLD etiologies, etiology classified using following hierarchy: hepatitis C virus (HCV) > B (HBV) alcohol-related all negative. All negative defined as for HCV,...
To evaluate the etiology of non-responsiveness to hepatitis B (HB) vaccination in adults from an endemic area.A total 250 subjects who were HBsAg negative and anti-HBs<10 mIU/ml received three-dose HB-vaccine series. Anti-HBs 'negative' was defined as a level<1.5 mIU/ml. 'Weakly' positive 1.5-10 at pre-vaccination testing. response level >10 post-vaccination Among non-responders anti-HBc positive, serum anti-HBe virus (HBV) DNA tested.Three variables associated with by univariate analysis:...
To assess the significance of adequate alpha-fetoprotein decrease in monitoring treatment effects radiofrequency ablation (RFA) hepatocellular carcinoma (HCC) patients.A total 72 RFA treatments 54 HCC patients were analyzed. The favorable was defined as half-life less than 7 days. efficacy response is assessed by standard imaging modality, a computed tomography scan 1 month after RFA. We correlation between different decreases and outcomes modality.Of therapies, 15 (21%) decreases. Fifty-one...
This prospective study was to assess the efficacy of nonbismuth containing quadruple therapy as first-line H. pylori treatment and determine clinical factors influencing patient outcome. We enrolled 200 -infected naïve patients. They were prescribed either a 7-day group (EACM, esomeprazole 40 mg twice daily, amoxicillin 1 g metronidazole 500 clarithromycin daily) or standard triple (EAC, daily). Follow-up studies responses carried out 8 weeks later. The eradication rates attained by EACM EAC...
Abstract Background and Aims: This study compared the efficacy safety of tenofovir disoproxil fumarate (TDF) up to 3 years innucleos(t)ide analog (NA)‐naïve NA‐experienced chronic hepatitis B (CHB) patients. Methods: Tenofovir fumarate‐treated NA‐naïve CHB patients were retrospectively analyzed. Results: After TDF therapy, 97.7%, 71%, 45.5% achieved a virological response, alanine aminotransferase normalization, e antigen seroconversion, respectively. Compared with patients, without drug...
Nivolumab and regorafenib are approved second-line therapies for patients with hepatocellular carcinoma (HCC) after sorafenib failure. This study compared the effectiveness of nivolumab following sorafenib.We retrospectively enrolled HCC who had undergone or Treatment response, treatment-related adverse events (TRAE) clinical outcomes were recorded analyzed.A total 90 (male/female: 67/23, mean age: 63 years) enrolled, including 32 in group 58 Regorafenib group. The better objective response...
A recent study from the US showed a decreasing trend in elevated serum alpha-fetoprotein (AFP) level (i.e., ≥20 ng/mL) hepatocellular carcinoma (HCC) patients at time of diagnosis. Furthermore, advanced tumor stage and severe underlying liver disease were associated with AFP levels. We aimed to evaluate this issue an area endemic for hepatitis B virus (HBV). Between 2011 2020, 4031 newly diagnosed HCC our institution. After excluding 54 unknown data, remaining 3977 enrolled study. Elevated...
Summary Background Most reports suggest that mutations in the interferon sensitivity‐determining region (ISDR) correlate with response to conventional interferon‐based therapies hepatitis C virus‐1b (HCV‐1b) patients. However, correlation between ISDR and pegylated plus ribavirin therapy HCV‐1b patients remains unclear. Aim To assess whether Peg Patients methods Sixty naive who had undergone 6 months of α‐2b a 6‐month follow‐up were enrolled. The amino acid sequences nonstructural...