The gut microbiota plays a role in nonalcoholic fatty liver disease (NAFLD), but data about dysbiosis Asians with NAFLD remains scarce. We analyzed the differences fecal between adults and without NAFLD. This cross-sectional study examined histology-proven (25 (NAFL) patients, 25 steatohepatitis (NASH) living donors (healthy controls)). taxonomic composition of was determined by 16S ribosomal RNA gene sequencing stool samples. NAFL NASH groups showed lower total bacterial diversity richness...

Foreign object ingestion and food bolus impaction are a common clinical problem. We report our experiences in endoscopic management for adults, foreign body ingestion, impaction.A retrospective chart review study was conducted on adult patients with between January 2011 November 2014. Patients incomplete medical records were excluded.A total of 198 (226 incidents) included the (male/female: 1.54/1; age 57 ± 16 years). Among them, 168 bodies found successfully (74.3%). 75.6% located...

The predictors of hepatitis B virus (HBV) relapse and HBsAg loss after cessation nucleos(t)ide analogues (NA) in HBeAg-negative patients with end-of-treatment ≤ 200 IU/mL remains unclear. study recruited 119 chronic (CHB) who achieved IU/mL, were treated lamivudine (n = 34) entecavir 85). 5-year rates post-treatment virological relapse, clinical at 60 months 39.4%, 27.6%, 45.9%, respectively. Cox regression analysis revealed that HBV DNA entry levels independent virolgical relapse. genotype...

Abstract Background & Aims Patients with chronic hepatitis C (CHC) after successful antiviral therapy remain at risk of hepatocellular carcinoma (HCC). This study was to determine whether liver stiffness measurement (LSM) useful in HCC assessment and develop a risk‐score system for clinical use. Methods retrospective enrolled patients CHC achieving sustained virological response (SVR) interferon‐based LSM at/after SVR determination. The demographics, characteristics development were...

Abstract Background Use of statins is associated with a reduced risk hepatocellular carcinoma (HCC). However, the effect statin use on HCC recurrence unclear. This study aimed to evaluate after curative resection among patients HCC. Methods We retrospectively assessed 820 Barcelona Clinic Liver Cancer (BCLC) stage 0 or A who underwent primary between January 2001 and June 2016 at Kaohsiung Chang Gung Memorial Hospital. Exposure was defined as for least 3 months before recurrence. Factors...

Non-B, non-C hepatocellular carcinoma (NBNC-HCC) may be related to metabolic syndrome, and the incidence of this tumor type is increasing annually. The definition metabolic-associated fatty liver disease (MAFLD) proposed in 2020 help more accuratelyassess association between syndrome NBNC-HCC. However, new concept has not yet been applied NBNC-HCC research. Therefore, study aimed compare clinicopathological characteristics patients with CHB-HCC diagnosed 2009-13 2014-18, focusing on risk...

Acid changes in gastroesophageal reflux with vary component the food have less been studied, especially carbohydrate. We plan to clarify effect of different carbohydrate density on low esophageal acid and symptoms patients gastroesophgeal disease. Twelve (52 ± 12 years old; five female) disease were recruited for prospective crossover study. Each patient was invited panendoscope, manometry 24 h pH monitor. The two formulated liquid meal, test meal A: 500 ml (containing 84.8 g carbohydrate)...

Purpose: To assess the difference of first-line therapy for Helicobacter pylori in patients with or without type 2 diabetes (DM) and to investigate clinical factors influencing treatment outcomes. Patients methods: In total, 719 H. infection were treated 7-day standard triple therapy, whom 182 did 537 not have DM. Propensity score matched at a 1:2 ratio - age, sex body mass index was performed two groups, yielding DM group 147 non-DM 249 controls analysis. Urea breath test 6-8 weeks after...

Gut microbiology is associated with liver disease due to gut-liver circulation via the gut microbial-liver axis. There a paucity of data regarding effects treatment cure hepatitis C virus (HCV) infection on microbiota. The aim this study was evaluate fecal microbiota before and after direct antiviral agents (DAA) in patients HCV infection.This prospective conducted at Kaohsiung Chung-Gung Memorial Hospital, Taiwan, between December 2019 November 2020. We recruited chronic (CHC) receiving DAA...

Gastroesophageal reflux disease (GERD) affects a significant proportion of individuals, with life stress being contributing factor. This study aimed to investigate the correlation between psychosomatic evaluations, heart rate variability (HRV), and GERD in cohort individuals. Additionally, analyze sequencing changes following proton pump inhibitor (PPI) treatment identify predictive factors associated refractory GERD. A prospective 105 individuals esophagitis control group 50 participants...

Abstract Background Early-stage esophageal cancer is treated using endoscopic submucosal dissection and esophagectomy. Field cancerization in patients with early-stage affects treatment outcomes causes synchronous or metachronous head neck cancers. We hypothesized that esophagectomy could provide better overall relapse-free survivals cancer. Methods retrospectively identified early squamous cell carcinoma separated the into groups to compare survivals. Results The study included 106...

Background: The risk of first recurrence hepatocellular carcinoma (HCC) within years 5 to 10 after curative hepatectomy remains unknown. We aimed assess the incidence and prognostic factors for very late among patients who achieved years’ recurrence-free survival (RFS) primary resection. Methods: retrospectively analyzed 337 with early-stage HCC underwent tumor resection more than RFS. Results: A total 77 (22.8%) developed recurrence. cumulative rate increased from 6.9% 11.7% 16.6% at 6, 7,...

Abstract Background and Aim Delayed gastric emptying occurs in more than 50% of chronic diabetic patients, this is associated with significant impairments quality life. Traditional therapy for delayed has focused on supportive treatment, there no effective therapy. The effect low‐energy shock wave motility never studied. We investigated a rat model. Methods Twenty‐eight male Wistar rats were studied separated three groups randomized order as control, received wave, the sham procedure. Antral...

Previous studies have indicated that lamivudine-induced hepatitis B e antigen (HBeAg) seroconversion may not be durable in the Asian population. We investigated useful predictors of post-treatment virus (HBV) relapse patients with nucleos(t)ide analogue (NA)-induced HBeAg loss/seroconversion.A total 157 non-cirrhotic NA-induced loss/seroconversion (78, lamivudine; 68, entecavir; 11, telbivudine) were retrospectively analyzed. All had at least 12 months follow-up and consolidation therapy...

Endoscopic submucosal dissection (ESD) as an advanced endoscopic procedure can be considered for the removal of colorectal lesions with high suspicion limited invasion or cannot optimally removed by snare-based techniques. We aimed to analyze clinical outcomes ESD neoplasms in our hospital.We retrospectively enrolled 230 patients 244 who received procedures from April 2012 October 2020 at Kaohsiung Chang Gung Memorial Hospital. Clinicopathological data were collected chart review. also...

AIMTo compare the one-week clinical effects of single doses dexlansoprazole and esomeprazole on grades A B erosive esophagitis. METHODSWe enrolled 175 adult patients with gastroesophageal reflux disease (GERD).The were randomized in a 1:1 ratio into two sequence groups to define order which they received (n = 88) 87) for an intention-to-treat analysis.The primary endpoints complete symptom resolution (CSR) rates at days 1, 3, 7 after drug administration. RESULTSThirteen lost follow-up,...

High-dose dual therapy (HDDT) can attain acceptable eradication rates provided that the optimal doses, timing and treatment duration are applied. The existing evidence still shows inconsistent reports (< 90%) on HDDT except in some Asian countries. We aimed to assess compare efficacy of 14-day by comparing it rabeprazole-containing hybrid (HT) investigate host bacterial factors predicting outcomes therapies. In this open-label, randomized controlled trial, we recruited 243 naïve Helicobacter...

Non-bismuth containing quadruple therapy (concomitant therapy) is an alternative treatment for Helicobacter pylori (H. pylori) eradication with increasing clarithromycin-resistant strains over times. This study compared the efficacies of non-bismuth in first-line anti-Helicobacter Pylori between two time intervals (January 2013 to June 2014 and 2016 December 2017).H. pylori-infected patients were recruited intention-to-treat (ITT analysis) divided into EACM-A group (enrolled from January...

Background and Objectives: The impact of direct-acting antiviral (DAA)-based regimens on the recurrence hepatocellular carcinoma (HCC) after successful curative hepatectomy is controversial. Aims: This study aimed to assess association between DAAs treatment risk in HCC resection. Materials Methods: We retrospectively assessed 152 cases early stage (BCLC 0/A) hepatitis C virus (HCV)-related (HCV-HCC) that underwent resection with intent 2001 2019 at Kaohsiung Chang Gung Memorial Hospital; 48...

Patients with chronic kidney disease (CKD) and Helicobacter pylori (H. pylori) infection have a higher incidence of gastroduodenal diseases therefore are recommended to receive eradication therapies. This study aimed assess the efficacy 7-day standard triple therapy in patients CKD (eGFR < 60 ml/min/1.73 m2) investigate clinical factors influencing success eradication.A total 758 H. receiving first-line between January 1, 2013, December 31, 2014, were recruited. divided into two groups:...

Purpose: Research comparing the clinical efficacy of dexlansoprazole and esomeprazole has been limited. This study aims to compare single doses (modified-release 60 mg) (40 after 24-week follow-up in patients with mild erosive esophagitis. Methods: We enrolled 86 adult GERD subjects, randomized a 1:1 ratio two sequence groups defining order which they received (n=43) for 8 weeks as initial treatment. Patients displaying complete symptom resolution (CSR) by end treatment (8 weeks) were...