The first-line eradication rate of standard triple therapy for Helicobacter pylori infection has declined to <80%, and alternative therapies with >90% success rates are needed. Inconsistent were reported proton pump inhibitor- amoxicillin-containing high-dose dual therapy. We performed a prospective, randomized controlled study assess the efficacy esomeprazole- investigated influencing clinical factors. recruited 240/278 eligible H. pylori-infected patients after exclusion. They randomly...

The gut microbiota plays a role in nonalcoholic fatty liver disease (NAFLD), but data about dysbiosis Asians with NAFLD remains scarce. We analyzed the differences fecal between adults and without NAFLD. This cross-sectional study examined histology-proven (25 (NAFL) patients, 25 steatohepatitis (NASH) living donors (healthy controls)). taxonomic composition of was determined by 16S ribosomal RNA gene sequencing stool samples. NAFL NASH groups showed lower total bacterial diversity richness...

Inflammatory markers are regarded as prognostic factors of the outcomes hepatocellular carcinoma (HCC). Examples include neutrophil-to-lymphocyte ratio (NLR); platelet to lymphocyte (PLR); albumin and counts used in nutritional index (PNI); neutrophil, lymphocyte, systemic immune-inflammation (SII). This study evaluates effects PNI, NLR, PLR, SII predict recurrence survival patients with Barcelona Clinic Liver Cancer (BCLC) stages 0-A HCC after hepatectomy. retrospective was conducted at...

Backgrounds and Aim: Metabolic-associated fatty liver dis-ease (MAFLD) is a novel term proposed in 2020 to avoid the exclusion of certain subpopulations, though application this real world very limited. Here, we aimed evaluate impact MAFLD on hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after curative resection. Methods: Patients with chronic (CHB)-related HCC who received hepatectomy between January 2010 December 2019 were consecutively selected. The association...

There is an alarming surge in food wastage stemming from culinary practices and intricate cuisines despite technological advancements. The reduction a pivotal sustainable development goal, yet statistics indicate high levels of wastage. Scholars have investigated waste extensively with focus on the hospitality sector, which accounts for nearly 12% total waste. Factors contributing to been examined, findings tend be isolated lack holistic approach. Existing research leans heavily toward...

This study investigated the ability of hepatitis B core-related antigen (HBcrAg) to predict virus (HBV) relapse in HBeAg-negative patients after cessation entecavir therapy. A total 301 without cirrhosis who had stopped therapy for at least 12 months were recruited. All fulfilled stopping criteria proposed by APASL 2012 guidelines. The five-year cumulative rates virological relapse, clinical and HBsAg loss 71.6%, 57.3% 18.7%, respectively. Serum end treatment (EOT) was an independent...

Non-B, non-C hepatocellular carcinoma (NBNC-HCC) may be related to metabolic syndrome, and the incidence of this tumor type is increasing annually. The definition metabolic-associated fatty liver disease (MAFLD) proposed in 2020 help more accuratelyassess association between syndrome NBNC-HCC. However, new concept has not yet been applied NBNC-HCC research. Therefore, study aimed compare clinicopathological characteristics patients with CHB-HCC diagnosed 2009-13 2014-18, focusing on risk...

There is an increasing trend in the incidence of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) worldwide. The aim present study was to identify prognostic factors patients with GEP-NENs. A cross-sectional, retrospective chart review conducted among pathologically proven GEP-NENs between January 2003 and December 2016 at Kaohsiung Chung-Gung Memorial Hospital. total 97 who met inclusion criteria were included (male/female = 56/41, age: 57.7 ± 15.4 years). presentation, clinical...

Background Metformin is proposed to have chemopreventive effect of various cancer currently. However, the anti-cancer metformin for diabetic patients with hepatocellular carcinoma (HCC) undergoing liver resection remains unclear. The aim our cohort study was assess whether influence recurrence HCC. Methods We retrospectively enrolled 857 HCC who received primary from April 2001 June 2016. 222 were diagnosed diabetes mellitus (DM) medical record. Factors overall survival (OS) and...

Gut microbiology is associated with liver disease due to gut-liver circulation via the gut microbial-liver axis. There a paucity of data regarding effects treatment cure hepatitis C virus (HCV) infection on microbiota. The aim this study was evaluate fecal microbiota before and after direct antiviral agents (DAA) in patients HCV infection.This prospective conducted at Kaohsiung Chung-Gung Memorial Hospital, Taiwan, between December 2019 November 2020. We recruited chronic (CHC) receiving DAA...

Background: The risk of first recurrence hepatocellular carcinoma (HCC) within years 5 to 10 after curative hepatectomy remains unknown. We aimed assess the incidence and prognostic factors for very late among patients who achieved years’ recurrence-free survival (RFS) primary resection. Methods: retrospectively analyzed 337 with early-stage HCC underwent tumor resection more than RFS. Results: A total 77 (22.8%) developed recurrence. cumulative rate increased from 6.9% 11.7% 16.6% at 6, 7,...

Gastroesophageal reflux disease (GERD) affects a significant proportion of individuals, with life stress being contributing factor. This study aimed to investigate the correlation between psychosomatic evaluations, heart rate variability (HRV), and GERD in cohort individuals. Additionally, analyze sequencing changes following proton pump inhibitor (PPI) treatment identify predictive factors associated refractory GERD. A prospective 105 individuals esophagitis control group 50 participants...

This study investigates the attitudes, perceived value, and repurchase intentions of elderly population towards green restaurants. With increasing proportion in Taiwan, their dietary needs have become more refined, focusing on health nutritional value. Consequently, restaurants offering healthy, nutritious, environmentally conscious food choices are likely to be favored by this demographic. The social also a consideration; that provide friendly, relaxed environment may one options for...

Abstract Background The albumin–bilirubin (ALBI) grade has been validated as a significant prognostic predictor for hepatocellular carcinoma (HCC). However, there is little information about the ALBI in patients with non-B non-C HCC (NBNC-HCC) receiving surgery. Aim This study aimed to evaluate significance of NBNC-HCC after primary curative resection. Method From January 2010 April 2016, 2137 who received hepatectomy were screened eligibility. Finally, total 168 resection analyzed. impacts...

Background and Objectives: The impact of direct-acting antiviral (DAA)-based regimens on the recurrence hepatocellular carcinoma (HCC) after successful curative hepatectomy is controversial. Aims: This study aimed to assess association between DAAs treatment risk in HCC resection. Materials Methods: We retrospectively assessed 152 cases early stage (BCLC 0/A) hepatitis C virus (HCV)-related (HCV-HCC) that underwent resection with intent 2001 2019 at Kaohsiung Chang Gung Memorial Hospital; 48...

Background: Evidence supporting the feasibility of single-stage stone removal in patients with a moderate grade acute cholangitis remains insufficient. The maximal size common bile-duct suitable for during ERCP is unknown. Methods: We prospectively enrolled 196 endoscopic retrograde cholangiopancreatography (ERCP)-naïve diagnosed and choledocholithiasis. For eligible patients, treatment involved at initial ERCP. Results: A total 123 were included final analysis. success rate complete...

Background and Aim . Liver fibrosis is associated with the prognosis of patients hepatocellular carcinoma (HCC) after resection. The fibrosis-4 (FIB-4) index an accurate noninvasive marker to determine degree liver fibrosis. Here, we evaluated effect pre- postoperative FIB-4 in predicting outcomes resection HCC who have chronic hepatitis B (CHB) infection. Methods A total 534 CHB received curative hepatectomy between 2001 2016 at Kaohsiung Chang Gung Memorial Hospital, Taiwan, were enrolled...

Cholecystectomy has been reported to be associated with increased risk of developing hepatocellular carcinoma (HCC). However, there is little information about the impact cholecystectomy on outcome HCC.To evaluate long-term effect concurrent recurrence and overall survival in HCC after curative hepatectomy.We retrospectively enrolled 857 patients BCLC stage 0 or A who underwent primary resection from January 2001 June 2016. The (OS) recurrence-free (RFS) were analyzed by Cox's proportional...

High-dose dual therapy (HDDT) using proton-pump inhibitors (PPI) and amoxicillin attracted attention for its simplicity lower adverse event profile. Besides, vonoprazan is not available worldwide. This real-world study aims to compare the efficacy of esomeprazole-based rabeprazole-based HDDT regimens identify clinical factors influencing outcomes.

Abstract Increased uptake of hepatitis C virus (HCV) treatment among people who inject drugs (PWID) is critical to achieve HCV elimination goals. This study attempted observe the influence different referral strategies HCV‐infected PWID for direct‐acting antivirals (DAA). From January 2019 November 2020, approximately 190 regularly received opioid agonist therapies (OAT) in drug addiction rehabilitation clinic our institute. Among these, those with positive anti‐HCV were further referred...