A5046646454- Synthesis and biological activity
- Natural product bioactivities and synthesis
- Traditional and Medicinal Uses of Annonaceae
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- Plant-based Medicinal Research
- Synthesis of Organic Compounds
- Bioactive Natural Diterpenoids Research
- Bioactive Compounds and Antitumor Agents
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Berberine and alkaloids research
- Phytochemistry and Biological Activities
- Phytochemical compounds biological activities
- Quinazolinone synthesis and applications
- Biological Activity of Diterpenoids and Biflavonoids
- Alkaloids: synthesis and pharmacology
- Chemical synthesis and alkaloids
- Cancer Treatment and Pharmacology
- Botanical Research and Chemistry
- Synthesis and Catalytic Reactions
- Synthetic Organic Chemistry Methods
- Estrogen and related hormone effects
- Metal complexes synthesis and properties
- Multicomponent Synthesis of Heterocycles
University of North Carolina at Chapel Hill
2014-2024
Communities In Schools of Orange County
2017
Indiana University School of Medicine
2011-2012
National Institutes of Health
2004-2010
National Institute of Environmental Health Sciences
2004-2010
University of California, Irvine
2010
The University of Texas MD Anderson Cancer Center
2010
National Institute for Basic Biology
2000-2005
Triangle
2004-2005
Yokohama City University
1995
Twelve novel 20-sulfonylamidine derivatives (9a–9l) of camptothecin (1) were synthesized via a Cu-catalyzed three-component reaction. They showed similar or superior cytotoxicity compared with that irinotecan (3) against A-549, DU-145, KB, and multidrug-resistant (MDR) KBvin tumor cell lines. Compound 9a demonstrated better MDR cells 1 3. Mechanistically, induced significant DNA damage by selectively inhibiting Topoisomerase (Topo) I activating the ATM/Chk related damage-response pathway. In...
A series of newly synthesized hydroxylated analogues triethyldesmosdumotin B (TEDB) with a bicyclic B-ring exhibited significantly different mode action for affecting microtubule dynamics and spindle formation but had the same antiproliferative activity spectrum, including against multidrug-resistant tumors. These efficiently induced cell cycle arrest at prometaphase caused immature multipolar spindles. 6'-Hydroxyl TEDB-TB (8) disrupted bipolar negligible effect on interphase microtubules....
Tabercorymines A (1) and B (2), two new vobasinyl–ibogan-type bisindole alkaloids with an unprecedented skeleton, were isolated from Tabernaemontana corymbosa. Their structures established by a combination of spectroscopic data, chemical transformation, single-crystal X-ray diffraction, ECD calculation. Compound 1 represents novel alkaloid, characterized caged heteropentacyclic ring system incorporating C-7/C-20 bond in the vobasinyl unit. Alkaloids 2 showed potent antiproliferative activity...
Natural triterpenoids, such as oleanolic acid (OA) and hederagenin, display anti-lung cancer effects, nitric oxide (NO) is associated with some oncogenic signaling pathways. Accordingly, 17 OA/hederagenin–NO donor hybrids were designed, synthesized, evaluated against tumor cells. The most potent compound, 13, significantly inhibited the proliferation of five cell lines (IC50 4.6–5.2 μM), while hederagenin growth only A549 cells > 10 μM). Furthermore, compound 13 showed stronger inhibitory...
Nineteen vobasinyl-ibogan-type bisindole alkaloids, including nine new compounds, taburnaemines A–I (1–9), were isolated from the twigs and leaves of Tabernaemontana corymbosa. The structures absolute configurations alkaloids determined by a combination MS, NMR, ECD analyses. Alkaloids 1–5 contain rare 1,3-oxazinane moiety in vobasinyl unit, while 6 has an uncommon 1,3-oxazolidine iboga unit. alkaloid 1 known tabernaecorymbosine A (10) confirmed single-crystal X-ray diffraction analysis. All...
Oocytes in humans, mice and other mammals lack identifiable centrioles. The proximal centriole brought by the fertilizing sperm humans most appears to gives rise centrioles at spindle poles zygote, is believed indicate that are inherited through paternal lineage. However, both distal degenerate rodents. A bipolar mitotic nucleates from multiple centrosome-like structures mouse zygote not seen until blastocyst stage, suggesting maternal lineage mice. We previously identified speriolin as a...
// Tsung-I Hsu 1,2 , Ying-Jung Chen 2 Chia-Yang Hung 3 Yi-Chang Wang Sin-Jin Lin Wu-Chou Su 4 Ming-Derg Lai 1,3,5 Sang-Yong Kim 6 Qiang Keduo Qian Masuo Goto Yu Zhao Yoshiki Kashiwada 7 Kuo-Hsiung Lee 6,8 Wen-Chang Chang 1,2,3,9,10 and Jan-Jong 1 Center for Infection Disease Signal Research, College of Medicine, National Cheng Kung University, Tainan, Taiwan Institute Bioinformatics Biosignal Transduction, Bioscience Biotechnology, Basic Medical Sciences, Department Internal Medicine...
7-Methoxy-4-(2-methylquinazolin-4-yl)-3,4-dihydroquinoxalin-2(1H)-one (2), a promising anticancer lead previously identified by us, inhibited tumor growth 62% in mice at 1.0 mg/kg without obvious signs of toxicity. Moreover, compound 2 exhibited extremely high antiproliferative activity the NIH-NCI 60 human cell line panel, with low to sub-nanomolar GI50 values (10-10 M level). It also showed suitable balance between aqueous solubility and lipophilicity, as well moderate metabolic stability...
Novel dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) analogues were designed and synthesized to improve their chemosensitizing action on KBvin (vincristine-resistant nasopharyngeal carcinoma) cells, a multidrug resistant cell line overexpressing P-glycoprotein (P-gp). Structure-activity relationship analysis showed that aromatic bulky aliphatic side chains at the 2,2'-positions effectively significantly sensitized P-gp (MDR) cells anticancer drugs, such...
Twelve benzylisoquinoline alkaloids, including pavine and phenanthroindolizidine types, were isolated from a MeOH/CH2Cl2 extract of Cryptocarya laevigata (stem bark) through bioactivity-guided fractionation for antitumor effects. Selected compounds evaluated antiproliferative activity against five human tumor cell lines, multidrug-resistant subline. Since more common 2,3,8,9-tetrasubstituted such as crychine (3), exhibit very mild or no cytotoxicity, this compound type has not been well...
A new chromone, 2-(2-hydroxy-2-phenylethyl)chromone (1), was isolated together with ten known phenylethyl chromones from MeOH extracts of agarwood (Aquilaria filaria). The selected compounds were evaluated in an antiproliferative assay against five human tumor cell lines, including a multidrug-resistant line. They also tested for antitumor promoting activity, as mediated by 12-O-tetradecanoylphorbol-13-acetate-induced activation the Epstein-Barr virus early antigen Raji cells. Among all...