A5048223814- Cancer therapeutics and mechanisms
- Liver physiology and pathology
- Plant-derived Lignans Synthesis and Bioactivity
- Insect Pest Control Strategies
- Synthesis and Biological Evaluation
- Insect Resistance and Genetics
- Synthetic Organic Chemistry Methods
- Global Educational Reforms and Inequalities
- Cancer Mechanisms and Therapy
- Insect-Plant Interactions and Control
- Bioactive Compounds and Antitumor Agents
- PI3K/AKT/mTOR signaling in cancer
- Synthesis and biological activity
- Parental Involvement in Education
- Education Systems and Policy
- Cyclopropane Reaction Mechanisms
- School Choice and Performance
- Fungal Plant Pathogen Control
- Entomopathogenic Microorganisms in Pest Control
- Youth Education and Societal Dynamics
- Biological Activity of Diterpenoids and Biflavonoids
- Single-cell and spatial transcriptomics
- Antibiotics Pharmacokinetics and Efficacy
- Advanced biosensing and bioanalysis techniques
- Pneumocystis jirovecii pneumonia detection and treatment
Jilin Agricultural University
2025
Southeast University
2025
Shaanxi University of Technology
2024
Harbin Institute of Technology
2017-2024
Shenzhen Second People's Hospital
2023-2024
Chinese University of Hong Kong
2021-2024
University of Science and Technology of China
2024
Shenzhen University
2023
Lanzhou University
2013-2019
Wuhan University
2018
Twelve novel 20-sulfonylamidine derivatives (9a–9l) of camptothecin (1) were synthesized via a Cu-catalyzed three-component reaction. They showed similar or superior cytotoxicity compared with that irinotecan (3) against A-549, DU-145, KB, and multidrug-resistant (MDR) KBvin tumor cell lines. Compound 9a demonstrated better MDR cells 1 3. Mechanistically, induced significant DNA damage by selectively inhibiting Topoisomerase (Topo) I activating the ATM/Chk related damage-response pathway. In...
Three novel series of N3-substituted imidacloprid derivatives were designed and synthesized, their structures identified on the basis satisfactory analytical spectral ((1)H NMR, (13)C MS, elemental analysis, X-ray) data. Preliminary bioassays indicated that all exhibited significant insecticidal activities against Aphis craccivora, with LC50 values ranging from 0.00895 to 0.49947 mmol/L, some them comparable those control imidacloprid. Some key structural features related identified, binding...
An enantiospecific semisynthesis of puupehedione was achieved from sclareolide in only 7 steps with an overall yield 25%. The key drimanal trimethoxystyrene skeleton constructed by the palladium-catalyzed cross-coupling reaction aryl iodine and a hydrazone. situ CAN-oxidation/intramolecular oxa-Stork–Danheiser transposition tandem used as powerful tool to install concurrently C D rings one-pot fashion. Its applicability also showcased puupehenone puupehenol.
Abstract This study aimed to explore the effects of CLIC 1 gene silencing on proliferation, migration, invasion and apoptosis human gallbladder cancer ( GBC ). normal tissues were extracted for detection mRNA protein expressions 1. ‐ SD NOZ cells in logarithmic growth phase selected conduct experiment. Three different si RNA recombined expression vectors established using as a target at sites. Reverse transcription quantitative polymerase chain reaction RT qPCR ) Western blotting were,...
Benzophenone hydrazone derivatives are among the most important classes of synthetic insecticides. In an effort to discover new molecules with good insecticidal/acaricidal activities, a series novel benzophenone N-acylated thiourea and urea was synthesized bioassayed.All these compounds exhibited excellent bioactivities against T. cinnabarinus B. brassicae, especially towards LC50 values ranging from 0.305 2.036 mmol L(-1). Moreover, acaricidal activities 8a-i, 12b-f 12h were 2.5-5.5-fold...
As part of our continuous efforts to discover novel c-Met inhibitors as antitumor agents, four series thiazole/thiadiazole carboxamide-derived analogues were designed, synthesised, and evaluated for the in vitro activity against human cancer cell lines. After five cycles optimisation on structure-activity relationship, compound 51am was found be most promising inhibitor both biochemical cellular assays. Moreover, exhibited potency several mutants. Mechanistically, not only induced cycle...
The use of camptothecin and its analogues has increased in clinical settings agriculture. Therefore, camptothecins their derivatives, metabolites degradation products are frequently found the environment. it is important to develop an ELISA for quantification human plasma, plants, animal tissues other matrices. present study developed a novel competitive indirect using monoclonal antibody (MAb). In total, two haptens various carrier proteins were tested select most suitable immunogen...
N-Sulfonyl- and N-acylpyrroles were synthesized via olefin ring-closing metathesis of diallylamines in situ oxidative aromatization the presence ruthenium Grubbs catalyst a suitable copper catalyst. In Cu(OTf)2 CuBr2, reaction afforded N-sulfonyl- N-acylpyrroles, respectively, one pot. Under an oxygen atmosphere, went smoothly without need hydroperoxide oxidants. This protocol possesses many advantages, such as using nonhazardous oxidant readily available starting materials, operating pot,...