CYR61 (CCN1) is a member of the CCN family secreted matricellular proteins that includes connective tissue growth factor (CCN2), NOV (CCN3), WISP-1 (CCN4), WISP-2 (CCN5), and WISP-3 (CCN6). First identified as product factor-inducible immediate-early gene, an extracellular matrix-associated angiogenic inducer functions ligand integrin receptors to promote cell adhesion, migration, proliferation. Aberrant expression Cyr61 associated with breast cancer, wound healing, vascular diseases such...

cyr61 was first identified as a growth factor-inducible immediate-early gene in mouse fibroblasts.The encoded Cyr61 protein is secreted, cysteine-rich heparin-binding that associates with the cell surface and extracellular matrix, these aspects it resembles Wnt-1 number of known factors.During embryogenesis, expressed most notably mesenchymal cells are differentiating into chondrocytes vessel walls developing circulatory system.cyr61 member an emerging family encodes regulators, including...

Abstract Background Excessive microglial activation is implicated in the pathogenesis of various age-related neurodegenerative diseases. In addition to neurons, brain-derived neurotrophic factor (BDNF) and its receptor TrkB are also expressed microglia. However, direct effect BDNF on has rarely been investigated. Methods We began address this question by examining age BDNF-TrkB pathway mice. By using pharmacological genetic approaches, roles downstream signaling pathways related...

Atherosclerosis occurs preferentially at the blood vessels encountering flow turbulence. The matricellular protein CCN1 is induced in endothelial cells by disturbed flow, and expressed advanced atherosclerotic lesions patients Apoe-/- mouse model. role of atherosclerosis remains undefined.To assess function vivo, knock-in mice carrying integrin α6β1-binding-defective mutant allele Ccn1-dm on background were tested an model generated carotid artery ligation. Additionally, CCN1-regulated...

The matricellular protein CCN1 (formerly named CYR61) regulates cell adhesion, migration, proliferation, survival, and differentiation through binding to integrin receptors heparan sulfate proteoglycans. Here we show that Ccn1 -null mice are impaired in cardiac valvuloseptal morphogenesis, resulting severe atrioventricular septal defects (AVSD). Remarkably, haploinsufficiency for also results delayed formation of the ventricular septum embryo persistent ostium primum atrial (ASD) ≈20%...

The cysteine-rich angiogenic protein 61 (Cyr61) is an extracellular matrix-associated, heparin-binding that mediates cell adhesion, stimulates migration, and enhances growth factor-induced proliferation. Cyr61 also promotes chondrogenic differentiation induces neovascularization. In this study, we show a 2-kb fragment of the promoter, which confers factor-inducible expression in cultured fibroblasts, able to drive accurate reporter gene lacZ transgenic mice. Thus, transgene was observed...

Ganoderma mushrooms, used in traditional Chinese medicine to promote health and longevity, have become widely accepted as herbal supplements. lucidum (GL), a commonly seen ganoderma species, is commercially cultivated under controlled conditions for more consistent chemical composition. The medicinal properties of GL are attributable its antioxidant anti‐inflammatory activities. We intended assess the effect atherosclerosis, an arterial condition associated with chronic oxidative stress...

Background/Aims: The protective role of sesamol and its possible action against isoproterenol-induced myocardial injury infarction is unknown. We tested the hypothesis that sesamol's protection associated with inhibition matrix metalloproteinase (MMP)-2 MMP-9. Methods: Four groups experimental rats were subcutaneously injected (0, 1, 3, or 10 mg/kg) then, 2 h later, intraperitoneally isoproterenol (100 mg/kg 24 apart on consecutive days) to induce infarction. Control treated saline only....

Expression of extracellular matrix protein CCN1 is induced in end-stage ischaemic cardiomyopathy humans, and after cardiac ischaemia reperfusion experimental animal models. Despite its well-documented angiogenic activities, increases the cytotoxicities tumour necrosis factor family cytokines, which promotes apoptosis fibroblasts. We aimed to determine physiological function an injured heart.To assess vivo, knock-in mice carrying apoptosis-defective mutant allele Ccn1-dm were tested...

Ganoderma mushrooms ( Lingzhi in Chinese) have well‐documented health benefits. tsugae G. ), one of the ganoderma species, has been commercially cultivated as a dietary supplement. Because high antioxidant activity and because oxidative stress is often associated with cardiac injury, we hypothesized that protects against injury by alleviating stress. We tested hypothesis using work‐overload‐induced myocardial model created challenging mice isoproterenol (ISO). Remarkably, oral protected from...

Background : Hypokalemia and hypertension are common manifestations of preclinical cardiovascular conditions that have a predictive value for morbidity mortality. Cardiac hypertrophy, an important risk factor in heart failure, is attributed to long‐term hypokalemia hypertension. Sesame oil rich nutrients possesses potent antihypertensive activities. Methods We investigated the therapeutic potential sesame using hypertensive model created by subcutaneously injecting deoxycorticosterone...

Wall shear stress (WSS) is a crucial hemodynamic factor that promotes atherosclerosis (plaque) development in arteries; although the relationship between WSS and arterial has been explored many animal studies, it not fully understood. No suitable tool, however, exists for rapidly estimating dynamic small-animal studies. This study proposes 40-MHz high-frequency ultrasound (HFUS) imaging system estimation based on mouse carotid artery blood flow velocity gradient measurements by vector...

// Pei-Ling Hsu 1, 2 , Fan-E Mo 1 Institute of Basic Medical Sciences, College Medicine, National Cheng Kung University, Tainan, Taiwan Department Cell Biology and Anatomy, Correspondence to: Mo, e-mail: femo@mail.ncku.edu.tw Keywords: CCN1, doxorubicin, cardiotoxicity, integrins, XIAP Received: November 09, 2015 Accepted: April 23, 2016 Published: May 4, ABSTRACT Doxorubicin (DOX) is an effective chemotherapeutic agent however its clinical use limited by cumulative cardiotoxicity....

Arterial pulse-wave velocity (PWV) is widely used in clinical applications to assess cardiovascular diseases. Ultrasound methods have been proposed for estimating regional PWV human arteries. Furthermore, high-frequency ultrasound (HFUS) has applied perform preclinical small-animal measurements; however, electrocardiogram (ECG)-gated retrospective imaging required achieve high-frame-rate imaging, which might be affected by arrhythmia-related problems. In this article, HFUS mapping based on...

Aortic aneurysm ( AA ) is a dilation of the aorta due to an arterial wall weakening. Chronic inflammation and oxidative stress have been associated with dysregulated vascular smooth muscle cell (VSMC) homeostasis functional phenotype leading loss VSMCs, matrix remodeling, formation. The matricellular protein CCN1 (cellular communication network factor 1) has identified in subpopulation VSMCs at early stage phenotypic switching. To assess involvement AA, expression was examined CaCl 2...

Previous observational studies reported an association of diabetes mellitus (DM) with oropharyngeal cancer (OPC), however, the potential causality between them remains unclear.

Introduction: Matricellular protein CCN1 is expressed in myocardial infarction, pressure overload, and ischemia mice, patients with a failing heart. Despite its well-documented angiogenic activities, promotes fibroblast apoptosis some contexts. The role of an injured heart was not clear. We assessed the hypothesis that plays detrimental mediates cardiac injury through proapoptotic activities. Methods Results: To test injury, we employed two different models including work-overload-induced...