A5088077074- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Vascular Anomalies and Treatments
- Cardiovascular Issues in Pregnancy
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Cardiomyopathy and Myosin Studies
- Cardiovascular and Diving-Related Complications
- Transplantation: Methods and Outcomes
- Cardiac Valve Diseases and Treatments
- Cardiovascular Effects of Exercise
- Nutrition and Health in Aging
- Sepsis Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Cardiac tumors and thrombi
- Viral Infections and Immunology Research
- Acute Ischemic Stroke Management
- Acute Myocardial Infarction Research
- Cardiac Structural Anomalies and Repair
- Congenital Heart Disease Studies
National Cheng Kung University Hospital
2016-2025
Kaohsiung Medical University
2020-2022
Arkansas Tech University
2022
National Cheng Kung University
2006-2021
Cardiovascular Institute of the South
2021
Stanford University
2021
Tri-Service General Hospital
2015
National Tsing Hua University
2013
University Medical Center
2007-2009
National Formosa University
2008
Background and Purpose Mitochondrial dysfunction plays a role in the progression of cardiovascular diseases including heart failure. 3‐Hydroxy‐3‐methylglutaryl‐CoA reductase inhibitors (statins), which inhibit ROS synthesis, show cardioprotective effects chronic However, beneficial statins mitochondrial protection failure remains unclear. Experimental Approach Rats were treated with angiotensin II (1.5 mg·kg −1 ·day ) or co‐administered simvastatin (oral, 10 for 14 days; then administration...
Epigenetic regulation and mitochondrial dysfunction are essential to the progression of idiopathic pulmonary fibrosis (IPF). Curcumin (CCM) in inhibits by regulating expression specific miRNAs fibroblast function; however, underlying mechanism is unclear. C57BL/6 mice were intratracheally injected with bleomycin (5 mg/kg) treated CCM (25 mg/kg body weight/3 times per week, intraperitoneal injection) for 28 days. Verhoeff–Van Gieson, Picro sirius red, Masson's trichrome staining used examine...
Objective: Ineffective triggering (IT) is the most common manifestation of patient–ventilator asynchrony in mechanically ventilated patients. IT expiratory phase (ITE) accounts for majority and associated with characteristic features flow airway pressure deflection, caused by ineffective effort from patient. The purpose this study was to quantify characteristics deflections ITE and, using a computerized algorithm, evaluate their usefulness detection ITEs. Design: Prospective, clinical study....
Abstract Background Long-term consumption of an excessive fat and sucrose diet (Western diet, WD) has been considered a risk factor for metabolic syndrome (MS) cardiovascular disease. Caveolae caveolin-1 (CAV-1) proteins are involved in lipid transport metabolism. However, studies investigating CAV-1 expression, cardiac remodeling, dysfunction caused by MS, limited. This study aimed to investigate the correlation between expression abnormal accumulation endothelium myocardium WD-induced...
Pulmonary hypertension (PH) is a rare but fatal condition. Large-scale studies to examine the prognostic factors are lacking. In present study, we aimed investigate associated with overall mortality in PH patients.Based on Taiwan's National Health Insurance Database, identified 1092 newly patients between 1999 and 2011. These were matched 8736 healthy subjects based propensity score calculated age, sex, chronic cardiovascular risk factors. Overall mortality, death incidence rate ratio,...
Pulmonary arterial hypertension (PAH) is characterized as a progressive and sustained increase in pulmonary vascular resistance, which may induce right ventricular failure. In 2014, the Working Group on Hypertension of Taiwan Society Cardiology (TSOC) conducted review data developed guideline for management PAH.4 recent years, several advancements diagnosis treatment PAH has occurred. Therefore, TSOC decided to come up with focused update that addresses clinically important advances...
Studies on mechanical-medical bridging for decompensated pulmonary hypertension (PH) are limited. We analysed the outcomes critical PH patients who underwent extracorporeal membrane oxygenation (ECMO) support using a bridge-to-recovery (BTR) strategy. This study aimed to identify prognostic factors of BTR and evaluate survivors. Between 2009 2012, 6 received veno-arterial ECMO due with cardiogenic shock were retrospectively reviewed. All managed an aggressive titration therapies optimization...
The aim of the present study was to assess association between invasive PWV (pulse wave velocity), serum levels MMPs (matrix metalloproteinases) and echocardiographic severity calcification score degenerative AS (aortic stenosis). We enrolled 30 patients (16 males; age, 61.3±8.2 years) diagnosed with an additional age- sex-matched control patients. Invasive methods a pigtail catheter double-channel recording were performed in both groups our catheterization laboratory. scored at AV valve)...
Lithium compounds have been widely used in the treatment of manic-depressive illness. Several electrocardiogram (ECG) abnormalities, including ventricular arrhythmias, atrioventricular conduction T wave changes and QT interval prolongation, reported to be associated with lithium. However, correlation between serum lithium levels ECG has never characterized a systematic way.This retrospective study included 76 patients undergoing available records levels. Eleven (4 men) had >1.2 mEq/l were...
The blood flow in the arteriovenous (AV) fistula is significantly reduced diabetic patients. Statins are known to mediate pleiotropic effects vascular endothelium and attenuate inflammatory responses. This study tested protective effect of rosuvastatin an experimental model AV fistula.One week after induction diabetes mellitus (DM) rats, a was created abdominal aorta inferior vena cava. Rats received placebo or (15 mg/kg/day) chow for 2 weeks. venous segments measured. expression...
Pulmonary arterial hypertension (PAH), defined as the presence of a mean pulmonary artery pressure > 20 mmHg, wedge ≤ 15 and vascular resistance (PVR) 2 Wood units based on expert consensus, is characterized by progressive sustained increase in PVR, which may lead to right heart failure death. PAH well-known complication connective tissue diseases (CTDs), such systemic sclerosis, lupus erythematosus, Sjogren's syndrome, other autoimmune conditions. In past few years, tremendous progress...
The objective of the present study was to develop a simple clinical model for predicting pulmonary embolism (PE) in patients with acute dyspnea emergency room. Patients and measurements: We enrolled 56 diagnosed PE, 92 consecutive without all whom presented Primary emergency-room physicians assessed initial evaluation interpretation various laboratory findings. Some significantly independent predictors PE were identified integrated into pretest probability: low (< 30%), intermediate (≥ 30%,...
Post-cardiac arrest care is critically important in bringing cardiac patients to functional recovery after the detrimental event. More high quality studies are published and evidence accumulated for post-cardiac recent years. It still a challenge clinicians integrate these scientific data into real clinical practice such complicated intensive involving many different disciplines.With cooperation of experienced experts from all disciplines relevant care, consensus statement was generated...
Right ventricular (RV) failure is a major cause of mortality in pulmonary arterial hypertension (PAH), but its mechanism remains largely unknown. MicroRNA-21 (miR-21) involved flow-mediated stress the vasculature, effects on RV remodeling require investigations. Herein, we aim to study miR-21 early (compensated) and late (decompensated) phases PAH-induced dysfunction. Using aorto-venous fistula (AVS) surgery, established rat model PAH. To mimic microenvironment PAH, treated cardiomyocytes...
Targeted temperature management (TTM) is recommended for comatose out-of-hospital cardiac arrest (OHCA) survivors. Several prediction models have been proposed; however, most of these tools require data conversion and complex calculations. Early easy predictive model neurological prognosis in OHCA survivors with TTM warrant investigation.This multicenter retrospective cohort study enrolled 408 non-traumatic adult from the TaIwan network targeted ManagEment CARDiac (TIMECARD) registry during...
Background: Prolonged length of stay (LOS) following targeted temperature management (TTM) administered after cardiac arrest may affect healthcare plans and expenditures. This study identified risk factors for prolonged LOS in patients with receiving TTM explored the association between neurological outcomes TTM. Methods: The retrospective cohort consisted 571 non-traumatic aged 18 years or older, treated cardiopulmonary resuscitation (CPR), had a Glasgow Coma Scale score <8, were unable to...
Background: The long-term outcome on patients with chronic thromboembolic pulmonary hypertension (CTEPH) has not been ideal after standard medical treatment. However, good for CTEPH interventions such as endarterectomy (PEA) and balloon angioplasty (BPA) reported recently. aim of this study was to evaluate the impact PEA or BPA outcomes in Han-Chinese population. Methods: This a multi-center, prospective case-control study. Patients were enrolled between January, 2018 March, 2020. They...