A5048313601- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- HER2/EGFR in Cancer Research
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Obstructive Sleep Apnea Research
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Tuberculosis Research and Epidemiology
- Tracheal and airway disorders
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroscience of respiration and sleep
- Hemodynamic Monitoring and Therapy
- Chronic Lymphocytic Leukemia Research
- Malaria Research and Control
- Medical Imaging and Pathology Studies
- Pneumonia and Respiratory Infections
- Occupational exposure and asthma
Kaohsiung Chang Gung Memorial Hospital
2015-2024
Chang Gung University
2015-2024
Chang Gung Memorial Hospital
1996-2023
Weatherford College
2020-2021
Pulmonary and Critical Care Associates
2021
Chang Gung University of Science and Technology
2010-2017
Singapore General Hospital
2013
Xiamen Chang Gung Hospital
2011
Memorial Hospital of South Bend
1999-2003
Ratio
2001
Osimertinib is a third-generation, irreversible tyrosine kinase inhibitor of the epidermal growth factor receptor (EGFR-TKI) that selectively inhibits both EGFR-TKI–sensitizing and EGFR T790M resistance mutations. A phase 3 trial compared first-line osimertinib with other EGFR-TKIs in patients mutation–positive advanced non–small-cell lung cancer (NSCLC). The showed longer progression-free survival than comparator (hazard ratio for disease progression or death, 0.46). Data from final...
Osimertinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), potently and selectively inhibits EGFR-TKI-sensitizing EGFR T790M resistance mutations. In the Phase III FLAURA study (NCT02296125), first-line osimertinib improved outcomes vs comparator EGFR-TKIs in EGFRm advanced non-small cell lung cancer. This analysis identifies acquired mechanisms to osimertinib. Next-generation sequencing assesses circulating-tumor DNA from paired plasma samples (baseline disease...
PURPOSE The phase III CheckMate 722 trial (ClinicalTrials.gov identifier: NCT02864251 ) evaluated nivolumab plus chemotherapy versus in patients with epidermal growth factor receptor ( EGFR)–mutated metastatic non–small-cell lung cancer (NSCLC) after disease progression on EGFR tyrosine kinase inhibitors (TKIs). METHODS Patients first- or second-generation TKI therapy (without T790M mutation) osimertinib (with/without were randomly assigned 1:1 to (360 mg once every 3 weeks) platinum-doublet...
Plasma circulating tumor DNA (ctDNA) analysis is used for genotyping advanced non-small cell lung cancer (NSCLC); monitoring dynamic ctDNA changes may be to predict outcomes.This was a retrospective, exploratory of two phase III trials [AURA3 (NCT02151981), FLAURA (NCT02296125)]. All patients had EGFR mutation-positive (EGFRm; ex19del or L858R) NSCLC; AURA3 also included T790M-positive NSCLC. Osimertinib (FLAURA, AURA3), comparator EGFR-tyrosine kinase inhibitor (EGFR-TKI;...
Abstract Objective: To examine the efficacy of combined inspiratory and expiratory respiratory muscle training (RMT) with respect to swallowing function, pulmonary functional performance, dysarthria in patients stroke. Design: Prospective, randomized controlled trial. Setting: Tertiary hospital. Participants: The trial included 21 subjects (12 men, 9 women) aged 35 80 years presenting 6 months history unilateral stroke, weakness (≥70% predicted maximal pressure (MIP) and/or ≤70% (MEP)),...
To compare the clinical and laboratory characteristics disease severity between adults children with dengue in Taiwan 2002, we retrospectively studied 661 serologically confirmed dengue-infected patients (606 55 children) admitted June December 2002 to a single medical centre. The charts of were reviewed for demographic, clinical, imaging information. Compared children, adult found have: higher incidences arthralgia (P<0.001), myalgia (P=0.002), headache (P=0.028), abdominal pain (P=0.004)...
To investigate clinical course and outcome of dengue with acute respiratory failure (ARF), to identify related risk factors for acquiring ARF in dengue, we retrospectively studied 11 patients ARF. From June December 2002, a total 606 adult were diagnosed as having dengue. Eleven (1.8%) had complications The main causes sepsis (n = 6, 54.5%) upper gastrointestinal (UGI) bleeding 3, 27.3%). mortality rate was 72.7% 8). Additionally, univariate analysis showed that age, dyspnea, cough,...
Obstructive sleep apnea (OSA) is an independent cardiovascular risk factor to which autonomic nervous dysfunction has been reported be important contributor. Ninety subjects recruited from the center of a single medical were divided into four groups: normal snoring without OSA (apnea hypopnea index, AHI < 5, n = 11), mild (5 ≤ 15, 10), moderate (15 30, 24), and severe (AHI ≥ 45). Demographic (i.e., age, gender), anthropometric body mass neck circumference), polysomnographic (PSG) data...
Rationale: Asthma is often work-related and can be classified as atopic or nonatopic on the basis of its pathogenesis. Few studies have reported an association between exposure to occupational asthmogens asthma with without atopy.Objectives: We investigated, in adults asthma, whether influenced risk having their level lung function.Methods: recruited 504 hospital-based current community-based control subjects, subjects southern Taiwan. atopy was defined combination increase total IgE (≥100...
Mutations on epidermal growth factor receptor (EGFR) of adenocarcinomas lung have been found to be associated with increased sensitivity EGFR tyrosine kinase inhibitors and K-ras mutations may correlate primary resistance. We aimed explore the discordant mutation statuses between tumors matched brain metastases in lung. used a sensitive Scorpion ARMS method analyze mutation, Sanger sequencing followed by allele-specific real-time polymerase chain reaction mutation. Forty-nine paired tissues...
Liver metastasis has been found to affect outcome in prostate cancer and colorectal cancer, but its role lung is unclear. The current study aimed evaluate the impact of de novo liver (DLM) on stage IV non-small cell (NSCLC) outcomes examine whether tyrosine kinase inhibitors (TKI) reverse poor prognosis patients with DLM epidermal growth factor receptor (EGFR)-mutant NSCLC. Among 1392 newly diagnosed NSCLC patients, 490 disease treated between November 2010 March 2014 at Kaohsiung Chang Gung...
ABSTRACT Background and objective: The BODE index, based on BMI, obstructive ventilatory impairment, dyspnoea scale exercise capacity, has been used to evaluate the severity of patients with COPD. However, correlations between serum biomarkers index in stable COPD are not widely studied. This study evaluated potential for their ability identify smokers reflect disease severity. Methods: A comparative was conducted 100 clinically 50 matched healthy difference levels measured. Serum...
Abstract Objectives To investigate the incidence of active tuberculosis (TB) among COPD patients using fluticasone/salmeterol or budesonide/formoterol, and to identify any differences between these two groups patients. Methods The study enrolled from Taiwan NHIRD who received treatment with budesonide/formoterol for > 90 days 2004 2011. TB was primary outcome. Results Among intention-to-treat population prior matching, rates were 0.94 0.61% in groups, respectively. After group had...
Summary Background Comparative long‐term efficacy of entecavir (ETV) and tenofovir disoproxil fumarate (TDF) for prevention disease progression to hepatocellular carcinoma (HCC) among high‐risk patients with chronic hepatitis B (CHB)‐related compensated cirrhosis is controversial. Aims To compare the ETV TDF in HCC CHB‐related cirrhosis, evaluate predictive risk factors development. Methods From January 2008 March 2018, 894 treatment‐naïve on or were enrolled based longitudinal cohort study....
A genome-wide association study uncovered Chitinase 3 like 1 (CHI3L1) as a candidate gene for asthma susceptibility. CHI3L1, which encodes the YKL-40 protein, is associated with in Western European and American populations atopy Korean population. However, asthma-associated polymorphisms remain unknown Taiwanese We enrolled 628 adult asthmatic patients 1:1 age-sex matched community-based controls southern Taiwan performed combined effect sizes analysis to test if CHI3L1 were related genetic...