A5044475640- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- Intensive Care Unit Cognitive Disorders
- Hemodynamic Monitoring and Therapy
- Inflammasome and immune disorders
- Atmospheric aerosols and clouds
- Ginger and Zingiberaceae research
- Antibiotic Use and Resistance
- Histiocytic Disorders and Treatments
- Remote Sensing in Agriculture
- Cardiac Arrest and Resuscitation
- Piperaceae Chemical and Biological Studies
- Ocular and Laser Science Research
- Neonatal and Maternal Infections
- Respiratory Support and Mechanisms
- Liver Disease Diagnosis and Treatment
- Streptococcal Infections and Treatments
- Atmospheric chemistry and aerosols
- Non-Invasive Vital Sign Monitoring
- Renal function and acid-base balance
- interferon and immune responses
- Epigenetics and DNA Methylation
- Nosocomial Infections in ICU
- Disaster Response and Management
- Neutropenia and Cancer Infections
Kaohsiung Medical University
2021-2023
Kaohsiung Chang Gung Memorial Hospital
2012-2020
Chang Gung University
2017-2020
Shanghai Changzheng Hospital
2012
Birmingham Children's Hospital
1978
Abstract The association between sepsis and segmented neutrophil-to-monocyte (SeMo) ratio is unclear. We postulated that an increase in dynamic SeMo measurement can be applied risk stratification. This retrospective study included 727 consecutive patients medical intensive care units (ICUs), including a subpopulation of 153 patients. According to the leukocyte (white blood cell, WBC) count on day 3 (normal range, 4,000/µL 12,000/µL) delta (value minus value 1; normal SeMo, <7), were...
Piplartine (or Piperlongumine) is a natural alkaloid isolated from Piper longum L., which has been proposed to exhibit various biological properties such as anti-inflammatory effects; however, the effect of piplartine on sepsis not examined. This study was performed examine activities in vitro, ex vivo and using murine J774A.1 macrophage cell line, peritoneal macrophages, bone marrow-derived macrophages an animal model. The results demonstrated that suppresses iNOS COX-2 expression, reduces...
Zerumbone is a natural product isolated from the pinecone or shampoo ginger, Zingiber zerumbet (L.) Smith, which has wide range of pharmacological activities, including anti-inflammatory effects. However, effects zerumbone on activation NLRP3 inflammasome in macrophages have not been examined. This study aimed to examine LPS-induced inflammatory responses and using murine J774A.1 cells, peritoneal macrophages, bone marrow-derived macrophages. Cells were treated with following LPS LPS/ATP...
Background Sepsis-induced immune dysfunction ranging from cytokines storm to immunoparalysis impacts outcomes. Monitoring enables better risk stratification and mortality prediction is mandatory before widely application of immunoadjuvant therapies. We aimed develop validate a scoring system according patients' status for 28-day prediction. Methods A prospective observational study cohort adult sepsis patients admitted ICU between August 2013 June 2016 at Kaohsiung Chang Gung Memorial...
Abstract We hypothesized that Ventilator-Associated Event (VAE) within 28 days upon admission to medical intensive care units (ICUs) can be a predictor for poor outcomes in sepsis patients. aimed determine the risk factors and associated of VAE. A total 453 consecutive mechanically ventilated (MV) patients were enrolled. Of them, 136 had immune profile study. Early VAE (< 7-day MV, n = 33) was with higher mortality (90 days: 81.8% vs. 23.0% [non-VAE], P < 0.01), while late (developed...
Immune checkpoint blockade (ICB) therapy can improve the survival of cancer patients with a high tumor mutation burden (TMB-H) or deficiency in DNA mismatch repair (dMMR) their tumors. However, most without TMB-H and dMMR do not benefit from ICB therapy. The inhibition ATM increase damage activate interferon response, thus modulating immune microenvironment (TIME) efficacy In this study, we showed that activated signaling induced interferon-stimulated genes (ISGs) cisplatin-resistant parent...
Background Immunoparalysis was observed in both patients with cancer and sepsis. In patients, Cytotoxic T lymphocyte antigen-4 programmed cell death protein 1/programmed death-ligand 1 axis are two key components of immunoparalysis. Several emerging therapies against these axes gained significant clinical benefit. severe sepsis immunoparalysis known as compensatory anti-inflammatory response syndrome this has been suggested an important cause It would be interesting to see if immune status...
Zearalenone (ZEA) is a mycotoxin that has several adverse effects on most mammalian species. However, the of ZEA macrophage-mediated innate immunity during infection have not been examined. In present study, bacterial lipopolysaccharides (LPS) were used to induce activation macrophages and evaluate inflammatory responses inflammation-associated signaling pathways. The experimental results indicated suppressed LPS-activated by including attenuating production proinflammatory mediators (nitric...
Objective The aim of this study was to determine whether do-not-resuscitate (DNR) orders affect outcomes in patients with sepsis admitted intensive care unit (ICU). Design This is a retrospective observational study. Participants We enrolled 796 consecutive adult at Kaohsiung Chang Gung Memorial Hospital, 2700-bed tertiary teaching hospital southern Taiwan. A total 717 were included. Main measures Clinical factors such as age, gender and other clinical possibly related DNR mortality...
We aimed to determine whether the combination of dynamic pulse pressure and vasopressor (DPV) use is applicable for mortality risk stratification in patients with severe sepsis. proposed DPV tool compared it traditional sepsis severity indices. All adult who met criteria Third International Consensus Definitions Sepsis Septic Shock (Sepsis-3) between August 2013 January 2017 were eligible study. Patients expired within 3 days admission intensive care unit (ICU) excluded. The primary outcomes...
OBJECTIVE: Castleman's disease (CD) is a rare disorder of unknown aetiology characterized by lymph node enlargement. This study evaluated the clinical features, diagnosis and outcomes surgical treatment in patients with CD. METHODS: The medical records 10 histologically confirmed CD who underwent surgery between 2003 2008 were retrospectively reviewed. Study endpoints survival recurrence. RESULTS: age onset ranged from 11 to 63 years (median 38 years). Of included study, eight diagnosed...
stances, when the alcoholic is also depressed and has suicidal ten- dencies, it would seem wise to avoid drug altogether.I should like thank HM Coroner for Bedfordshire permission publish details of these cases; scientific officers at Home Office Forensic Science Laboratory, Aldermaston, Reading, who performed analyses; Dr J C Valentine, consultant pathologist
Introduction: Ionic hypocalcaemia (IH) seen after blood transfusion during liver transplantation(LT) may result in hemodynamic instability. We have previously reported that the risk of intraoperative IH still exits patients receiving only 5% albumin without transfusion. The adult undergoing LT who did not receive products nor but crystalloids is to be elucidated. aim current study evaluate this group and compare it with our earlier experience. Methods: anesthesia records LDLT recipients were...
Background and Aims: To determine whether ICU patients with sepsis due to pneumonia or non-pneumonia were associated different characteristics outcomes.Methods: This study evaluated adult medical (18 y/o) in Kaohsiung Chang Gung Memorial Hospital.799 consecutive who met the criteria of sepsis-3 included.Results: According infection source for sepsis, divided into group (N = 276), community-acquired (CAP) 387) hospital-acquired (HAP) 136).With compatible age, APACH II score, Charlson...