A5100457139- RNA modifications and cancer
- Mathematical and Theoretical Epidemiology and Ecology Models
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- Evolution and Genetic Dynamics
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Biosensors and Analytical Detection
- Diet and metabolism studies
- Fractional Differential Equations Solutions
- Cancer-related gene regulation
- Blood Coagulation and Thrombosis Mechanisms
- Genetic and phenotypic traits in livestock
- Bone Metabolism and Diseases
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Head and Neck Cancer Studies
- Genomics, phytochemicals, and oxidative stress
- Venous Thromboembolism Diagnosis and Management
- RNA Interference and Gene Delivery
- Nonlinear Dynamics and Pattern Formation
- S100 Proteins and Annexins
- Mathematical Biology Tumor Growth
State Grid Corporation of China (China)
2025
Capital Medical University
2018-2025
Wenzhou Medical University
2024-2025
Beijing Institute of Technology
2025
Hangzhou First People's Hospital
2024-2025
Westlake University
2024-2025
Changhai Hospital
2006-2024
China Rehabilitation Research Center
2022-2024
Shanghai Institute of Hematology
2024
Chinese Academy of Agricultural Sciences
2020-2024
Objective Currently, there is no cure for chronic pancreatitis (CP). Germline loss-of-function variants in SPINK1 (encoding trypsin inhibitor) are common patients with CP and associated acute attacks progression of the disease. This preclinical study was conducted to explore potential adeno-associated virus type 8 (AAV8)-mediated overexpression human ( hSPINK1 ) therapy mice. Design A capsid-optimised AAV8-mediated expression vector (AAV8- target pancreas constructed. Mice were treated AAV8-...
m6A modification has been studied in tumors, but its role host anti-tumor immune response and TAMs polarization remains unclear. The fatty acid oxidation (FAO) process of is also attracting attention. A co-culture model colorectal cancer (CRC) cells macrophages was used to simulate the tumor microenvironment. Expression changes demethylase genes FTO ALKBH5 were screened. further investigated. Gain-of-function experiments conducted study ALKBH5's effects on macrophage M2 polarization, CRC...
Apatinib, a commonly used tyrosine kinase inhibitor in cancer treatment, can cause adverse reactions such as hypertension. Hypertension, turn, increase the risk of certain cancers. The coexistence these diseases makes use combination drugs more common clinical practice, but potential interactions and regulatory mechanisms drug combinations are poorly understood. We humanized CYP2D6 mouse model to predict effect apatinib on pharmacokinetics pharmacodynamics metoprolol investigated...
Hysteroscopic surgery, a minimally invasive technique prevalent in gynecology, exhibits an overall complication rate between 0.22% and 3.7%. Pulmonary bleeding post-hysteroscopy represents exceedingly rare with only three reported cases to date; two involving high-viscosity solutions one hypertonicity solutions. Negative-pressure pulmonary hemorrhage, seldomly encountered lethal complication, manifests post-upper airway obstruction, minimal documented cases, none within hysteroscopic...
Although major advances have been made in bovine epigenome study, the epigenetic basis for fetal skeletal muscle development still remains poorly understood. The aim is to recapitulated time course of vitro, and explore dynamic changes chromatin accessibility gene expression during myoblasts proliferation differentiation.PDGFR- cells were isolated from muscle, then cultured induced myogenic differentiation vitro a time-course study (P, D0, D2,and D4). assay transposase-accessible sequencing...
Abstract Background Existence of breast cancer stem cells (BCSCs) is implicated in disease relapse, metastasis, and resistance treatment. β1,3-Galactosyltransferase 5 (B3GALT5) has been shown to be a pro-survival marker for BCSCs. However, little known about the prognostic significance B3GALT5 cancer. Methods Paired tissues (tumor part adjacent non-tumor part) from cohort 202 women with were used determine expression levels mRNA by qRT-PCR. Kaplan–Meier multivariable Cox proportional hazard...
Both ferroptosis and lncRNAs are significant for ovarian cancer (OC). Whereas, the study of ferroptosis-related (FRLs) still few in cancer. We first constructed an FRL-signature patients with OC study. A total 548 FRLs were identified univariate Cox regression analysis, 21 prognosis identified. The prognostic characteristics nine was validated, showing opposite two subgroups based on risk scores. multivariate analysis nomogram further verified value model. By calculating score through...
This study aimed to investigate the effect and mechanism of lupeol on cerebral ischemia-reperfusion injury in rats.The effects infarction, water content, neurological symptoms blood flow rats were evaluated. Nissl staining was carried out assess neuronal damage ischemic brain after I/R rats. Apoptosis neurons detected by TUNEL staining. Western blotting detect expression p-PDK1, p-Akt, pc-Raf, p-BAD, cleaved caspase-3 p-PTEN.Lupeol significantly increased rats, reduced content infarct...
Huaxi cattle, a specialized beef cattle breed in China, has the characteristics of fast growth, high slaughter rate, and net meat good reproductive performance, strong stress resistance, wide adaptability. In this study, we evaluated genetic diversity, population structure, relationships its ancestor populations at genome-wide level, as well detecting selection signatures cattle. Principal component analysis (PCA) phylogenetic revealed that were obviously separated from other populations....
Steroid-dependent asthma (SDA) is characterized by oral corticosteroid (OCS) resistance and dependence. Wumeiwan (WMW) showed potentials in reducing the dose of OCS SDA patients based on our previous studies.Network pharmacology was conducted to explore molecular mechanism WMW against with databases TCMSP, STRING, etcetera. GO annotation KEGG functional enrichment analysis were metascape database. Pymol performed docking. In experiment, OVA-induced plus descending dexamethasone intervention...
Ginkgolide B (GB) is a natural occurring terpene lactone and selective agonistic ligand of hPXR.
Bone cancer pain (BCP) is a clinically intractable mixed pain, involving inflammation and neuropathic its mechanisms remain unclear. CXC chemokine receptor 1 (CXCR1, IL-8RA) 2 (CXCR2, IL-8RB) are high-affinity receptors for interleukin 8 (IL8). According to previous studies, CXCR2 plays crucial role in BCP between astrocytes neurons, while the of CXCR1 remains The objective this study was investigate BCP. We found that expression increased spinal dorsal horn. Intrathecal injection siRNA...
Species differences in CYP2D6 drug metabolism complicate the extrapolation of vivo pharmacokinetic data to humans and impact prediction responses. This study aimed develop an model predict human responses metabolized compounds evaluate medication risks disease development.