A5100378102- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related molecular mechanisms research
- Animal Disease Management and Epidemiology
- Influenza Virus Research Studies
- Livestock Farming and Management
- Meat and Animal Product Quality
- Respiratory viral infections research
- Animal Nutrition and Physiology
- Bioinformatics and Genomic Networks
- Viral gastroenteritis research and epidemiology
- Genetic Associations and Epidemiology
- Genetics and Plant Breeding
- RNA modifications and cancer
- Virus-based gene therapy research
- Genomic variations and chromosomal abnormalities
- Language, Metaphor, and Cognition
- Chromosomal and Genetic Variations
- Microbial infections and disease research
- Genomics and Chromatin Dynamics
- Molecular Biology Techniques and Applications
- Animal Virus Infections Studies
- Genomics and Phylogenetic Studies
- Calcium signaling and nucleotide metabolism
- Forensic and Genetic Research
Chinese Academy of Agricultural Sciences
2015-2024
Institute of Animal Sciences
2017-2024
Chinese Academy of Forestry
2024
Oregon National Primate Research Center
2024
Oregon Health & Science University
2024
Shanghai Veterinary Research Institute
2020-2023
Ministry of Education of the People's Republic of China
2023
Institute of Crop Sciences
2016-2023
Northwest A&F University
2023
Ministry of Agriculture and Rural Affairs
2020-2022
Latent transforming growth factor β-binding protein 1 (LTBP-1) targets latent complexes of β to the extracellular matrix, where cytokine is subsequently activated by several different mechanisms. Fibrillins are matrix macromolecules whose primary function architectural: fibrillins assemble into ultrastructurally distinct microfibrils that ubiquitous in connective tissue space. LTBPs and highly homologous molecules, colocalization cultured cells has been reported. To address whether LTBP-1...
Certain low pathogenic avian influenza viruses can mutate to highly when they circulate in domestic poultry, at which point cause devastating poultry diseases and severe economic damage. The H7N9 that emerged 2013 China had caused human infections deaths. However, these were nonlethal poultry. It is unknown whether the acquire additional mutations during their circulation nature become lethal more dangerous for humans. Here, we evaluated evolution of isolated from species between 2017 found...
RACK1 dictates the response of intracellular stress sensor IRE1α to different extracellular stimuli.
Significance Animal influenza viruses continue to challenge human public health; surveillance of these and evaluation their pandemic potential are important for future preparedness. Pigs intermediate hosts novel generation transfer humans. Two lineages H1N1 swine (SIVs), classical SIVs Eurasian avian-like (EAH1N1) SIVs, have been circulating in pigs since 1918 1979, respectively. The emerged humans as a reassortant caused the 2009 pandemic. Here, we found that, after long-term evolution...
Previous studies have shown that the Eurasian avian-like H1N1 (EA H1N1) swine influenza viruses circulated widely in pigs around world and formed multiple genotypes by acquiring non-hemagglutinin neuraminidase segments derived from other viruses. Swine control is not a priority for pig industry many countries, it worrisome some strains may become more pathogenic and/or transmissible during their circulation nature. Our routine surveillance indicated EA obtained different internal genes...
Fatty acid composition of muscle is an important trait contributing to meat quality. Recently, genome-wide association study (GWAS) has been extensively used explore the molecular mechanism underlying traits in cattle. In this study, we performed GWAS using high density SNP array analyze between SNPs and fatty acids evaluated accuracy genomic prediction for Chinese Simmental cattle.Using BayesB method, identified 35 7 regions cattle that displayed significant associations with individual...
Recent advances in high-throughput genotyping technologies have provided the opportunity to map genes using associations between complex traits and markers. Genome-wide association studies (GWAS) based on either a single marker or haplotype identified genetic variants underlying mechanisms of quantitative traits. Prompted by achievements examining economic cattle verify consistency these two methods real data, current study was conducted construct structure bovine genome detect relevant...
Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to measure the expression of microRNA-155 in patients with temporal lobe epilepsy. Commercial kit and western blot analysis were gap-associated protein expression. The aim present study investigate effect microRNA‑155 (miRNA‑155) occurrence epilepsy molecular mechanism involved. In epilepsy, miRNA‑155 evidently higher than that normal volunteers group. Overexpression resulted decreased brain‑derived neurotrophic...
Summary We performed a genome‐wide association study to identify candidate genes for body measurement traits in 463 Wagyu beef cattle typed with the Illumina Bovine HD 770K SNP array. At level, we detected 18, five and one s associated hip height, height length respectively. In total, these are within or near 11 genes, six of which ( PENK , XKR 4, IMPAD 1 PLAG CCND 2 SNTG ) have been reported previously CSMD 3 LAP SYN FAM 19A5 TIMP novel that found be traits. Further exploration will...
Abstract Background A comprehensive analysis of gene expression profiling across tissues can provide necessary information for an in-depth understanding their biological functions. We performed a large-scale and generated high-resolution atlas the transcriptome in beef cattle. Results Our was from 135 bovine adult cattle, covering 51 tissue types major organ systems (e.g., muscular system, digestive immune reproductive system). Approximately 94.76% sequencing reads were successfully mapped...
A detailed understanding of genetic variants that affect beef merit helps maximize the efficiency breeding for improved production in cattle. To prioritize putative and genes, we ran a comprehensive genome-wide association studies (GWAS) analysis 21 agronomic traits using imputed whole-genome Simmental Then, applied expression quantitative trait loci (eQTL) mapping between genotype transcriptome three tissues (longissimus dorsi muscle, backfat, liver) 120 cattle.We identified 1,580 signals...
China exhibits a great diversity of ecosystems and abundant cattle resources, with nearly 30 million from 53 indigenous breeds reared in specific geographic regions. To explore the genetic population structure Chinese cattle, analysis at both individual levels was conducted admixture performed. We genotyped 572 samples 20 using GeneSeek Genomic Profiler Bovine LD (GGP-LD, K) downloaded published data 77 4 worldwide commercial Illumina BovineSNP50 Beadchip (SNP50, 50 K). In principal...
Abstract Genome-wide single nucleotide polymorphism (SNP) arrays can be used to explore homozygosity segments, where two haplotypes inherited from the parents are identical. In this study, we identified a total of 27,358 runs (ROH) with an average 153 ROH events per animal in Chinese local cattle. The sizes varied considerably ranging 0.5 66 Mb, length 1.22 Mb. highest proportion genome covered by (~11.54% cattle genome) was found Nanda (NDC) South China, whereas lowest (~3.1%) observed...
Carcass traits of beef cattle have been genetically improved to increase yield high quality meat. Genome-wide association study (GWAS) is a powerful method identify genetic variants associated with carcass traits. For the 770K genotyped SNPs from 1141 Chinese Simmental cattle, we used compressed mixed linear model (CMLM) perform genome-wide for knuckle, biceps and shank Seventeen significantly were found, which are located on BTA6, BTA14 BTA15. Interestingly, one pleiotropic quantitative...
Fatty acids are important traits that affect meat quality and nutritive values in beef cattle. Detection of genetic variants for fatty acid composition can help to elucidate the mechanism underpinning these promote improvement profiles. In this study, we performed a genome-wide association study (GWAS) on using high-density single nucleotide polymorphism (SNP) arrays Chinese Wagyu cattle.In total, detected 15 8 significant SNPs individual groups cattle, respectively. Also, identified nine...
Although major advances have been made in bovine epigenome study, the epigenetic basis for fetal skeletal muscle development still remains poorly understood. The aim is to recapitulated time course of vitro, and explore dynamic changes chromatin accessibility gene expression during myoblasts proliferation differentiation.PDGFR- cells were isolated from muscle, then cultured induced myogenic differentiation vitro a time-course study (P, D0, D2,and D4). assay transposase-accessible sequencing...
Global warming leads to frequent extreme weather, especially the heat events, which threating safety of maize production. Here we selected a pair inbred lines, PF5411-1 and LH150, with significant differences in tolerance at kernel development stage. The two lines were treated stress Compared control groups, transcriptomic analysis identified 770 common up- down-regulated genes between LH150 under conditions, 41 putative TFs predicted. Based on interaction term two-factorial design, also...
Abstract Bamboo-derived biochar has shown unique advantages in heavy metals immobilization due to its vascular bundles and high cellulose content. Phosphorus modification emerged as an effective way enhance biochar’s performance for removal, while their efficacy mechanisms Cd(II) remain unclear. To quantify the relative contribution of various on adsorption assess application potential, this study comparatively investigated by phytic acid-modified (PABC), sodium phytate-modified (SPBC),...
Background Bartonellosis is a zoonotic infectious disease caused by Bartonella spp. Small mammals are the most important hosts of and play an role in its long-term maintenance spread. The multi-organ studies help understand prevalence more systematically comprehensively. This study aimed to investigate small explore genetic diversity infected strains influencing factors from Mile City Lianghe County, Yunnan Province. Methods were captured County Province July August 2019. Spleen kidney...