A5041858151- Neurogenesis and neuroplasticity mechanisms
- Pacific and Southeast Asian Studies
- Axon Guidance and Neuronal Signaling
- Erythrocyte Function and Pathophysiology
- Archaeology and ancient environmental studies
- Ferroptosis and cancer prognosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Proteoglycans and glycosaminoglycans research
- Genetic and Kidney Cyst Diseases
- Vascular Malformations Diagnosis and Treatment
- Retinal Development and Disorders
- Chemical and Physical Studies
- Heart Rate Variability and Autonomic Control
- Extracellular vesicles in disease
- Estrogen and related hormone effects
- Barrier Structure and Function Studies
- Chemokine receptors and signaling
- Inflammasome and immune disorders
- Genetic Syndromes and Imprinting
- Cancer-related molecular mechanisms research
- Blood properties and coagulation
- Caveolin-1 and cellular processes
- Cardiac electrophysiology and arrhythmias
- Receptor Mechanisms and Signaling
- Prostate Cancer Treatment and Research
Tsinghua University
2022-2024
Center for Life Sciences
2022-2024
Beijing Proteome Research Center
2019-2021
Lanzhou University
2014-2020
Max Planck Institute for the Science of Human History
2020
Academy of Military Medical Sciences
2014
Cognitive impairment has been associated with an age-related decline in adult hippocampal neurogenesis (AHN). The molecular basis of declining the aging hippocampus remains to be elucidated. Here, we show that pleiotrophin (PTN) expression is decreased neural stem and progenitor cells (NSPCs). Mice lacking PTN exhibit impaired AHN accompanied by poor learning memory. Mechanistically, find engages protein tyrosine phosphatase receptor type Z1 (PTPRZ1) promote NSPC proliferation...
Chitinase-3–like protein 1 (CHI3L1) is primarily secreted by activated astrocytes in the brain and known as a reliable biomarker for inflammatory central nervous system (CNS) conditions such neurodegeneration autoimmune disorders like neuromyelitis optica (NMO). NMO an astrocyte disease caused autoantibodies targeting astroglial aquaporin 4 (AQP4) leads to vision loss, motor deficits, cognitive decline. In this study examining CHI3L1’s biological function neuroinflammation, we found that...
It is widely known that the Hexi Corridor in North‐West China lies at a hub of trans‐Eurasian cultural exchange. Its role became increasingly important during late prehistoric period, particularly as ancient Silk Road began to be used. While profound transformation local characteristics Neolithic and Bronze Age well documented, detailed economic dynamics evolution have not yet been clearly illustrated. In this paper, we report on significant new zooarchaeological faunal isotopic data from...
The low level of transcytosis is a unique feature cerebrovascular endothelial cells (ECs), ensuring restrictive blood-brain barrier (BBB) permeability. Major facilitator superfamily domain-containing 2a (MFSD2A) key regulator the BBB function by suppressing caveolae-mediated transcytosis. However, mechanisms regulating MFSD2A at have been barely explored. Here, we show that EC-specific deletion Pten (phosphatase and tensin homolog) results in dramatic increase vesicular reduction MFSD2A,...
Abstract Neuromyelitis optica spectrum disorder (NMOSD) is a severe inflammatory autoimmune disease of the central nervous system that manifested as secondary myelin loss. Oligodendrocyte progenitor cells (OPCs) are principal source myelinating oligodendrocytes (OLs) and abundant in demyelinated regions NMOSD patients, thus possibly representing cellular target for pharmacological intervention. To explore therapeutic compounds enhance myelination due to endogenous OPCs, we screened candidate...
This paper explores the possible provenance of ores employed for metallurgical production during Early Bronze Age in central Hexi Corridor north‐west China. In total, 78 pieces copper (Cu) ore samples were collected from five sites and one Cu deposit site (the Beishantang deposit) Heihe River region corridor. These dated to late Machang (4100–4000 bp ), Xichengyi (4000–3700 Qijia (4000–3600 ) Siba (3700–3400 cultures. After comparing with published lead (Pb) isotopic data other deposits...
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs), a key component of the endosomal sorting complex required for transport (ESCRT), has been implicated in many essential biological processes. However, physiological role endogenous Hgs vascular system not previously explored. Here, we have generated brain endothelial cell (EC) specific knockout mice to uncover function EC polarity and cerebrovascular stability.
Brain endothelial cells (ECs) are an important component of the blood-brain barrier (BBB) and play key roles in restricting entrance possible toxic components pathogens into brain. However, identifying genes that regulate BBB homeostasis remains a time-consuming process. Although somatic genome editing has emerged as powerful tool for discovery essential regulating tissue homeostasis, its application brain ECs is yet to be demonstrated