A5063770737- Advanced Glycation End Products research
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural Antidiabetic Agents Studies
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Neurogenesis and neuroplasticity mechanisms
- Alzheimer's disease research and treatments
- Virology and Viral Diseases
- Complement system in diseases
- Neurological Disease Mechanisms and Treatments
- Morinda citrifolia extract uses
- Advances in Cucurbitaceae Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Sirtuins and Resveratrol in Medicine
- Bioactive Compounds and Antitumor Agents
- Synthesis and bioactivity of alkaloids
- Pharmacological Receptor Mechanisms and Effects
- Extracellular vesicles in disease
- Adipose Tissue and Metabolism
- Studies on Chitinases and Chitosanases
- Neurogenetic and Muscular Disorders Research
- Mesenchymal stem cell research
- Genetics and Neurodevelopmental Disorders
- Neurological diseases and metabolism
- Alcohol Consumption and Health Effects
Institute of Genetics and Developmental Biology
2017-2024
Chinese Academy of Sciences
2017-2024
University of Leeds
2023-2024
University of Chinese Academy of Sciences
2024
Center for Excellence in Brain Science and Intelligence Technology
2017-2018
University of Karachi
2015-2017
International Center for Chemical and Biological Sciences
2015-2017
Highlights•5 out 16 tested Ebola virus entry inhibitors can inhibit ZIKV efficiently•Chloroquine internalization in vitro and reduce ZIKV-associated morbidity mortality mice•Chloroquine prevents congenital microcephaly miceZika (ZIKV) is an emerging which cause birth defects, however there are currently no effective treatments or vaccines. We the effects of verified cell on infection, found that chloroquine (CQ) could prevent infection cultures, consistent with results from a previous study....
Cognitive dysfunction is a feature in multiple sclerosis (MS), chronic inflammatory demyelinating disorder. A notable aspect of MS brains hippocampal demyelination, which closely associated with cognitive decline. However, the mechanisms underlying this phenomenon remain unclear. Chitinase-3-like (CHI3L1), secreted by activated astrocytes, has been identified as biomarker for progression. Our study investigates CHI3L1's function within hippocampus and demonstrates correlation between CHI3L1...
Chitinase-3–like protein 1 (CHI3L1) is primarily secreted by activated astrocytes in the brain and known as a reliable biomarker for inflammatory central nervous system (CNS) conditions such neurodegeneration autoimmune disorders like neuromyelitis optica (NMO). NMO an astrocyte disease caused autoantibodies targeting astroglial aquaporin 4 (AQP4) leads to vision loss, motor deficits, cognitive decline. In this study examining CHI3L1’s biological function neuroinflammation, we found that...
Several members of cucurbitaceae family have been reported to regulate growth cancer by interfering with STAT3 signaling. In the present study, we investigated unique role and molecular mechanism cucurbitacins (Cucs) in reducing symptoms metabolic syndrome mice. Cucurbitacin E (CuE) was found reduce adipogenesis murine adipocytes. CuE treatment diminished hypertrophy adipocytes, visceral obesity lipogenesis gene expression diet induced mice model (MetS). also ameliorated adipose tissue...
Abstract Neuromyelitis optica (NMO) is a severe autoimmune inflammatory disease of the central nervous system that affects motor function and causes relapsing disability. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have been used extensively in treatment various diseases, due to their potent regulatory roles can mitigate inflammation repair damaged tissues. However, use NMO currently limited, mechanism underlying beneficial effects hUC-MSCs on remains unclear. In this...
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease. To identify additional genetic factors, we analyzed exome sequences in large cohort of Chinese ALS patients and found homozygous variant (p.L700P) PCDHA9 three unrelated patients. We generated Pcdhα9 mutant mice harboring either orthologous point mutation or deletion mutation. These develop progressive spinal motor loss, muscle atrophy, structural/functional abnormalities the neuromuscular junction, leading to...
Zika virus (ZIKV) became a global threat due to its unprecedented outbreak and association with congenital malformations such as microcephaly in developing fetuses neonates. There are currently no effective vaccines or drugs available for the prevention treatment of ZIKV infection. Although multiple vaccine platforms have been established, their effectiveness preventing has not addressed. Herein, we tested subunit containing 450 amino acids at N-terminus envelope protein (E90) mouse models...
Several reports indicate anti-hyperglycemic effects of Syzygium aromaticum. In the present study, we report for first time that clove extract (SAM) and its compound nigricin (NGC) decreases free fatty acid-mediated insulin resistance in mouse myoblasts. addition, NGC was able to diminish a diabetic model. We observed SAM exhibited significant antioxidant activity murine skeletal muscle cells. They also modulated stress signaling by reducing p38 MAP kinase phosphorylation. treatments enhanced...