A5061960597- Extracellular vesicles in disease
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Phagocytosis and Immune Regulation
- Neurological Disease Mechanisms and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neurogenesis and neuroplasticity mechanisms
- Pulmonary Hypertension Research and Treatments
Cell Technology (China)
2024
Abstract Neuromyelitis optica (NMO) is a severe autoimmune inflammatory disease of the central nervous system that affects motor function and causes relapsing disability. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have been used extensively in treatment various diseases, due to their potent regulatory roles can mitigate inflammation repair damaged tissues. However, use NMO currently limited, mechanism underlying beneficial effects hUC-MSCs on remains unclear. In this...
To study the anti- fibrotic effect of human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-EXOs) and explore mechanism.Twenty-four C57 BL/6 mice were divided into 4 groups (n=6), including control group treated with intratracheal injection saline (3 mg/kg); lung fibrosis model 1.5 mg/mL bleomycin solution (prepared saline, 3 EXOs1 mg/kg) hUCMSC-EXOs (100 μg/250 μL, given by tail vein on next day after modeling); EXOs2 10th modeling). At 21 days modeling, pulmonary index,...
Intrathecal administration of human umbilical cord mesenchymal stem cells may be a promising approach for the treatment stroke, but its safety, effectiveness, and mechanism remain to elucidated. In this study, good manufacturing practice-grade (5 × 105 1 106 cells) saline were administered by cerebellomedullary cistern injection 72 hours after stroke induced middle cerebral artery occlusion in rats. The results showed (1) no significant difference mortality or general conditions among three...