A5022956950- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Animal Virus Infections Studies
- interferon and immune responses
- Immune Response and Inflammation
- COVID-19 Clinical Research Studies
- Viral Infections and Immunology Research
- COVID-19 epidemiological studies
- Herpesvirus Infections and Treatments
- Microbial infections and disease research
- Vector-Borne Animal Diseases
- SARS-CoV-2 and COVID-19 Research
- Cancer Research and Treatments
- Corruption and Economic Development
- Plant Virus Research Studies
- Political Economy and Marxism
- Bacteriophages and microbial interactions
- Monoclonal and Polyclonal Antibodies Research
- Corporate Finance and Governance
- Coccidia and coccidiosis research
- RNA and protein synthesis mechanisms
Harbin Veterinary Research Institute
2014-2025
Chinese Academy of Agricultural Sciences
2009-2025
Ministry of Agriculture and Rural Affairs
2025
Yantai University
2008
Heritage Christian University
2006
University of Kang Ning
2005
Sichuan University
2003
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) causes the infectious disease COVID-19 (coronavirus 2019), which was first reported in Wuhan, China, December 2019. Despite extensive efforts to control disease, has now spread more than 100 countries and caused a global pandemic. SARS-CoV-2 is thought have originated bats; however, intermediate animal sources of virus are unknown. In this study, we investigated susceptibility ferrets animals close contact with humans SARS-CoV-2....
A newly emerged H7N9 virus has caused 132 human infections with 37 deaths in China since 18 February 2013. Control measures virus-positive live poultry markets have reduced the number of infections; however, character virus, including its pandemic potential, remains largely unknown. We systematically analyzed viruses isolated from birds and humans. The were genetically closely related bound to airway receptors; some also maintained ability bind avian receptors. nonpathogenic chickens, ducks,...
Certain low pathogenic avian influenza viruses can mutate to highly when they circulate in domestic poultry, at which point cause devastating poultry diseases and severe economic damage. The H7N9 that emerged 2013 China had caused human infections deaths. However, these were nonlethal poultry. It is unknown whether the acquire additional mutations during their circulation nature become lethal more dangerous for humans. Here, we evaluated evolution of isolated from species between 2017 found...
Recently, an outbreak of highly pathogenic avian influenza A (H5N1), which carries the clade 2.3.4.4b hemagglutinin (HA) gene and has been prevalent among North American bird populations since winter 2021, was reported in dairy cows United States. As May 24, 2024, virus affected 63 herds across nine states resulted two human infections. The causes unusual symptoms cows, including unexpected drop milk production, thick colostrum-like milk. Notably, US Food Drug Administration that around 20%...
ABSTRACT In 2001 and 2003, we isolated two H5N1 viruses, A/swine/Fujian/1/01 (SW/FJ/01) A/swine/Fujian/1/03 (SW/FJ/03), from pigs in Fujian Province, southern China. Genetically, these viruses are similar, although the NS gene of SW/FJ/03 virus has a 15-nucleotide deletion at coding positions 612 to 626. The SW/FJ/01 is highly lethal for chickens, whereas nonpathogenic chickens when administrated intravenously or intranasally. To understand molecular basis difference virulence, used reverse...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the infectious disease COVID-19, which was first reported in Wuhan, China December, 2019. Despite tremendous efforts to control disease, COVID-19 has now spread over 100 countries and caused a global pandemic. SARS-CoV-2 is thought have originated bats; however, intermediate animal sources of virus are completely unknown. Here, we investigated susceptibility ferrets animals close contact with humans SARS-CoV-2. We...
Significance Animal influenza viruses continue to challenge human public health; surveillance of these and evaluation their pandemic potential are important for future preparedness. Pigs intermediate hosts novel generation transfer humans. Two lineages H1N1 swine (SIVs), classical SIVs Eurasian avian-like (EAH1N1) SIVs, have been circulating in pigs since 1918 1979, respectively. The emerged humans as a reassortant caused the 2009 pandemic. Here, we found that, after long-term evolution...
Previous studies have shown that the Eurasian avian-like H1N1 (EA H1N1) swine influenza viruses circulated widely in pigs around world and formed multiple genotypes by acquiring non-hemagglutinin neuraminidase segments derived from other viruses. Swine control is not a priority for pig industry many countries, it worrisome some strains may become more pathogenic and/or transmissible during their circulation nature. Our routine surveillance indicated EA obtained different internal genes...
Past pandemic influenza viruses with sustained human-to-human transmissibility have emerged from animal viruses. Employment of experimental models to assess the risk emerging zoonotic provides critical information supporting public health efforts. Ferret transmission experiments been utilized predict potential novel However, small sample sizes and a lack standardized protocols can introduce interlaboratory variability, complicating interpretation data. To range variation in ferret...
In investigating influenza in an immunodeficient child China, December 2010, we found that the virus showed high sequence identity to of swine. Serologic evidence indicated viral persistence pigs was source infection. Continued surveillance and systemic analysis swine isolates are needed.
The wild-type H1N1 and H3N2 swine influenza virus (SIV) strains are unsuitable for vaccine production because of high lethality in chicken embryos low reproductive titers. This study developed recombinant H1N1-Re1 H3N2-Re1 via HA NA genes from the SW/GX/755/17 SW/GX/1659/17 combined with six internal A/PR/8/34 strain. viruses demonstrated typical cytopathic effects MDCK cells, presence viral particles was confirmed electron microscopy. Growth curve analysis revealed titers 108.31 108.17...
Efficient transmission from human to is the prerequisite for an influenza virus cause a pandemic; however, molecular determinants of are still largely unknown. In this study, we explored basis Eurasian avian-like H1N1 (EAH1N1) swine viruses by comparing two that genetically similar but differ in their transmissibility guinea pigs: A/swine/Guangxi/18/2011 (GX/18) highly transmissible respiratory droplet pigs, whereas A/swine/Heilongjiang/27/2012 (HLJ/27) does not transmit animal model. We...
The continuous antigenic variation of influenza A viruses remains a major hurdle for vaccine selection; however, the molecular determinants and mechanisms change remain largely unknown. In this study, two escape mutants were generated by serial passages Eurasian avian-like H1N1 swine virus (EA SIV) A/swine/Henan/11/2005 (HeN11) in presence neutralizing monoclonal antibodies (mAbs) against hemagglutinin (HA) protein, which designated HeN11-2B6-P5 HeN11-4C7-P8, respectively. mutant...
Genetic reassortments occurred continuously among multiple subtypes or genotypes of influenza viruses prevalent in pigs. Of note, some reassortant bearing the internal genes 2009 pandemic H1N1 (2009/H1N1) virus sporadically caused human infection, which highlights their potential threats to public health. In this study, we performed phylogenetic analysis on swine (SIVs) circulating Liaoning Province, China. A total 22 viruses, including 18 and 4 H1N2 were isolated from 5,750 nasal swabs...
H6 avian influenza virus (AIV) is one of the most prevalent AIV subtypes in world. Our previous studies have demonstrated that AIVs isolated from live poultry markets pose a potential threat to human health. In recent years, increasing number has been constantly farms. order understand biological characteristics context farms, here, we analyzed phylogenetic relationships, antigenicity, replication mice and receptor binding properties farms China between 2014 2018. Phylogenetic analysis...
ABSTRACT Reassortant Eurasian avian-like H1N1 (rEA H1N1) viruses carrying the internal genes of H1N1/2009 virus have been circulating in pigs for more than 10 years and caused sporadic human infections. The enhanced virulence phenotype rEA highlights potential risks to public health. However, molecular mechanism underlying viral pathogenicity currently remains unclear. In this study, we found that two naturally isolated swine influenza viruses, A/swine/Liaoning/FX38/2017 (FX38)...