A5101565166- Influenza Virus Research Studies
- Nanoplatforms for cancer theranostics
- Animal Disease Management and Epidemiology
- Advanced biosensing and bioanalysis techniques
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Photoreceptor and optogenetics research
- Supercapacitor Materials and Fabrication
- Animal Virus Infections Studies
- Advanced Sensor and Energy Harvesting Materials
- Laser Material Processing Techniques
- Advanced Photocatalysis Techniques
- Laser Applications in Dentistry and Medicine
- TiO2 Photocatalysis and Solar Cells
- Epigenetics and DNA Methylation
- Nanoparticle-Based Drug Delivery
- Advancements in Battery Materials
- Nonlinear Optical Materials Studies
- Advanced Memory and Neural Computing
- Advanced Nanomaterials in Catalysis
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Battery Materials and Technologies
- Thin-Film Transistor Technologies
- MicroRNA in disease regulation
- Quantum Dots Synthesis And Properties
Nanjing University of Science and Technology
2025
China Agricultural University
2023-2025
The First Affiliated Hospital, Sun Yat-sen University
2023-2025
Zhongshan Hospital
2023-2025
Fudan University
2022-2025
Sun Yat-sen University
2017-2025
Jiangxi Agricultural University
2024-2025
Ministry of Industry and Information Technology
2024
Chinese Academy of Sciences
2023-2024
Northwestern Polytechnical University
2024
Influenza A viruses (IAVs), particularly H1N1, H5N1 and H7N9, pose a substantial threat to public health worldwide. Here, we report that MIR2911, honeysuckle (HS)-encoded atypical microRNA, directly targets IAVs with broad spectrum. MIR2911 is highly stable in HS decoction, continuous drinking or gavage feeding of decoction leads significant elevation the level mouse peripheral blood lung. Bioinformatics prediction luciferase reporter assay showed could target various IAVs, including H7N9....
A newly emerged H7N9 virus has caused 132 human infections with 37 deaths in China since 18 February 2013. Control measures virus-positive live poultry markets have reduced the number of infections; however, character virus, including its pandemic potential, remains largely unknown. We systematically analyzed viruses isolated from birds and humans. The were genetically closely related bound to airway receptors; some also maintained ability bind avian receptors. nonpathogenic chickens, ducks,...
H9N2 subtype influenza viruses have been detected in different species of wild birds and domestic poultry many countries for several decades. Because these are low pathogenicity poultry, their eradication is not a priority animal disease control countries, which has allowed them to continue evolve spread. Here, we characterized the genetic variation, receptor-binding specificity, replication capability, transmission mammals series that were live markets southern China between 2009 2013....
In the past, avian influenza viruses have crossed species barriers to trigger human pandemics by reassorting with mammal-infective in intermediate livestock hosts. H5N1 are able infect pigs, and some of them affinity for mammalian type α-2,6-linked sialic acid airway receptor. Using reverse genetics, we systematically created 127 reassortant between a duck isolate H5N1, specifically retaining its hemagglutinin (HA) gene throughout, highly transmissible, human-infective H1N1 virus. We tested...
Plant oils in the form of triacylglycerol (TAG) are used for food, industrial feedstock and biofuel manufacture. Although TAG is typically harvested from fruit or seeds oil crop species, plants can also accumulate small amounts leaves other vegetative tissues. Here we show that leaf levels be increased significantly (10-20 fold) by blocking fatty acid breakdown, particularly during extended dark treatments senescence model plant Arabidopsis. Generation a double mutant breakdown...
The conductive polypyrrole (PPy) polymer nanocomposites (PNCs) reinforced with different magnetite (Fe3O4) nanoparticle loadings have been successfully synthesized by using a facile surface initiated polymerization (SIP) method. scanning electron microscope (SEM) is used to characterize the morphology of as-received Fe3O4 nanoparticles (NPs), pure PPy and Fe3O4/PPy PNCs. high-resolution transmission (HRTEM) observe dispersion within matrix. chemical structure PNCs characterized Fourier...
Uracil-DNA glycosylase (UDG) is an important base excision repair (BER) enzyme responsible for the of uracil-induced DNA lesion and maintenance genomic integrity, while aberrant expression UDG associated with a variety cancers. Thus, accurate detection activity essential to biomedical research clinical diagnosis. Here, we develop fluorescent method ultrasensitive using repair-initiated enzyme-assisted bicyclic cascade signal amplification. This assay involves (1) UDG-actuated uracil-excision...
Influenza viruses of the H6 subtype have been isolated from wild and domestic aquatic terrestrial avian species throughout world since their first detection in a turkey Massachusetts 1965. Since 1997, with different neuraminidase (NA) subtypes detected frequently live poultry markets southern China. Although sequence information has gathered over last few years, not fully biologically characterized. To investigate potential risk posed by to humans, here we assessed receptor-binding...
Abstract Micro-algae synthesize high levels of lipids, carbohydrates and proteins photoautotrophically, thus attracting considerable interest for the biotechnological production fuels, environmental remediation, functional foods nutraceuticals. Currently, only a few micro-algae species are grown commercially at large-scale, primarily “health-foods” pigments. For range potential products (fuel to pharma), lipid productivity strains required mitigate economic costs mass culture. Here we...
Metastasis leads to the vast majority of breast cancer mortality. Increasing evidence has shown that N6-methyladenosine (m6A) modification and its associated regulators play a pivotal role in metastasis. Here, we showed overexpression m6A reader IGF2BP1 was clinically correlated with metastasis patients. Moreover, promoted distant vitro vivo. Mechanistically, first identified USP10 as deubiquitinase. can bind to, deubiquitinate, stabilize IGF2BP1, resulting higher expression level cancer....
Despite recent advancements in cancer immunotherapy, challenges have yet to be surmounted achieve two major goals of magnifying antitumor immunity and remodeling the immunosuppressive tumor microenvironment. Here, a nanosystem (ODM-R) that integrates oxygen-deficient molybdenum oxide (ODM) nanosonosensitizers R7 peptides with metabolism regulation effects is designed fabricated for synergistic sonodynamic-immunometabolic therapy spinal-metastasized tumors. The ODM generates reactive oxygen...
Organic light-emitting diodes (OLEDs) that are able to emit high levels of circularly polarized (CP) light hold significant promise in numerous future technologies. Such devices require chiral emissive materials enable CP electroluminescence. However, the vast majority current OLED emitter classes, including state-of-the-art triplet-harvesting thermally activated delayed fluorescence (TADF) materials, produce very low Here a host-guest strategy allows for energy transfer between polymer host...
Animal influenza viruses pose a clear threat to public health. Transmissibility among humans is prerequisite for novel virus cause human pandemic. A reassortant swine acquired sustained human-to-human transmissibility and caused the 2009 However, molecular aspects of transmission remain poorly understood. Here, we show that an amino acid in hemagglutinin (HA) important H1N1 pandemic (2009/H1N1) bind receptors confer respiratory droplet mammals. We found change from glutamine (Q) arginine (R)...
DNA methylation is an important epigenetic modification in human genomes. Herein, we develop a single quantum dot (QD)-based nanosensor for sensitive detection of at both CpG and non-CpG sites using tricyclic ligation chain reaction (LCR)-mediated QD-based fluorescence resonance energy transfer (FRET). We design two sets probes (X Y, X' Y') methylated assay. In the presence thermostable ligase, X Y may adjacently hybridize with to obtain ligated XY products which function as templates Y'...
5'-Polynucleotide kinase such as T4 polynucleotide (T4 PNK) may catalyze the phosphorylation of 5'-hydroxyl termini in nucleic acids, playing a crucial role DNA replication, recombination, and damage repair. Here, we demonstrate for first time single-molecule detection PNK based on phosphorylation-directed recovery fluorescence quenched by Au nanoparticle (AuNP) combination with lambda exonuclease-mediated cleavage reaction. In presence PNK, γ-phosphate group from adenosine triphosphate...
Herein, we develop a sensitive fluorescence method for microRNA assay based on duplex specific nuclease-assisted target recycling and pyrene excimer switching.
Inorganic semiconductor-based microscale light-emitting diodes (micro-LEDs) have been widely considered the key solution to next-generation, ubiquitous lighting and display systems, with their efficiency, brightness, contrast, stability, dynamic response superior liquid crystal or organic-based counterparts. However, reduction of micro-LED sizes leads deteriorated device performance increased difficulties in manufacturing. Here, we report a tandem scheme based on stacked red, green, blue...
H9N2 avian influenza viruses are widely prevalent in birds and pose an increasing threat to humans because of their enhanced virulence transmissibility mammals. Active surveillance on the prevalence evolution different hosts will help develop eradication measures. We isolated 16 from chickens, green peafowls, wild eastern China 2017 2019 characterized comparative genetic evolution, receptor-binding specificity, antigenic diversity, replication, transmission chickens mice. The phylogenetic...
Abstract Antibody‐nanoparticle conjugates are promising candidates for precision medicine. However, developing a controllable method conjugating antibodies to nanoparticles without compromising the antibody activity represents critical challenge. Here, facile and generalizable film‐coating is presented using zeolitic imidazole framework‐8 (ZIF‐8) immobilize on various in favorable orientation enhanced cell targeting. Different model therapeutic (e.g., Herceptin) assembled via biomineralized...