A5030802959- Mesenchymal stem cell research
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Gastrointestinal disorders and treatments
- Tissue Engineering and Regenerative Medicine
- Neonatal Respiratory Health Research
- CAR-T cell therapy research
- Drug-Induced Hepatotoxicity and Protection
- Fibroblast Growth Factor Research
- Phagocytosis and Immune Regulation
- Eosinophilic Esophagitis
- Periodontal Regeneration and Treatments
- Liver Disease Diagnosis and Treatment
- Immune cells in cancer
- Liver physiology and pathology
- Congenital Diaphragmatic Hernia Studies
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Asian Culture and Media Studies
- Cancer Cells and Metastasis
- Pancreatic function and diabetes
- Pluripotent Stem Cells Research
- Electrospun Nanofibers in Biomedical Applications
- Bacterial Infections and Vaccines
Changhai Hospital
2013-2025
National Clinical Research Center for Digestive Diseases
2025
Second Military Medical University
2013-2025
PLA Navy General Hospital
2024-2025
Naval University of Engineering
2025
Shanghai Institute of Hematology
2024
The University of Texas MD Anderson Cancer Center
2019-2022
Beike Biotechnology (China)
2014-2022
Cell Technology (China)
2019-2021
Associated Research (United States)
2021
Objective Currently, there is no cure for chronic pancreatitis (CP). Germline loss-of-function variants in SPINK1 (encoding trypsin inhibitor) are common patients with CP and associated acute attacks progression of the disease. This preclinical study was conducted to explore potential adeno-associated virus type 8 (AAV8)-mediated overexpression human ( hSPINK1 ) therapy mice. Design A capsid-optimised AAV8-mediated expression vector (AAV8- target pancreas constructed. Mice were treated AAV8-...
// Jiancheng Wang 1, 2, * , Yingnan Shaochuan 3, Jianye Cai 2 Jianqiang Shi 4 Xin Sui 5 Yong Cao 6 Weijun Huang Xiaoyong Chen Zijie Hongyu Li Adham Sameer A. Bardeesi Bin Zhang Muyun Liu Wu Song 3 Maosheng Andy Peng Xiang 7 1 The Biotherapy Center, Third Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China Center for Stem Cell Biology and Tissue Engineering, Key Laboratory Cells Ministry Education, Department Gastrointestinal-Pancreatic...
Genetic alterations may contribute to chronic pancreatitis (CP) in Chinese young patients. This study was designed investigate mutations of cationic trypsinogen (PRSS1), pancreatic secretory trypsin inhibitor or serine protease Kazal type 1 (SPINK1), cystic fibrosis transmembrane conductance regulator (CFTR), chymotrypsin C (CTRC) and CLDN2 genes the copy number variations (CNVs) PRSS1 asses associations with development idiopathic CP (ICP) children.Retrospective.A single center.75 ICP...
Abstract Background Interstitial pneumonia in connective tissue diseases (CTD-IP) featuring inflammation and fibrosis is a leading cause of death CTD-IP patients. The related autoimmune lung injury disturbed self-healing process make conventional anti-inflammatory drugs ineffective. Equipped with unique immunoregulatory regenerative properties, mesenchymal stem cells (MSCs) may represent promising therapeutic agent CTD-IP. In this study, we aim to define the immunopathology involved...
Liu, Muyun MD; Gao, Jie Sun, Chang Chen, Ying Shi, Xingang An, Wei MD Author Information
Mesenchymal stem cells (MSCs) are a promising cell resource for the treatment of ischemic diseases, partially through paracrine effects. One major obstacles MSC is poor survival rate and low efficiency transplanted due to or inflammatory environments. Gremlin1 (GREM1), regulator growth, differentiation development, has been identified as novel proangiogenic factor. However, role mechanism GREM1 in MSCs remains unclear. Therefore, we assessed putative beneficial effects on MSC-based therapy...
Mesenchymal stromal cells (MSCs) have shown great potential for treating inflammatory bowel disease, which is ameliorated through paracrine cross talk between MSCs and T-cells. Members of the insulin-like growth factor binding protein (IGFBP) family important immunomodulatory functions in MSCs, but underlying mechanisms behind these not yet been clearly elucidated. In this study, we investigate whether MSC-produced IGFBP7 involved immune modulation using a mouse experimental colitis model....
Abstract Background Pulmonary fibrosis (PF) is a growing clinical problem with limited therapeutic options. Human umbilical cord mesenchymal stromal cell (hucMSC) therapy being investigated in trials for the treatment of PF patients. However, little known about underlying molecular and cellular mechanisms hucMSC on PF. In this study, behavior was bleomycin-induced mouse model. Methods The effect hucMSCs lung regeneration determined by detecting Ki67 expression EdU incorporation alveolar type...
Accumulating evidence suggests that the gut microbiome is involved in pathogenesis of insulin resistance (IR). However, link between two most prevalent bowel disorders, chronic diarrhea and constipation, triglyceride glucose (TyG) index, a marker IR, has not yet been investigated.
Pneumococcal Polysaccharide Vaccine (PPV-23), designed to protect against the most common serotype of Streptococcus pneumoniae, is intended elderly and other high-risk groups. However, immunogenicity all 23 pneumococcal polysaccharide vaccines in older adults has not been thoroughly studied. The purpose this study look into factors that influence effect pneumonia vaccine on over 60 years old Shenzhen, as well their IgG antibody level pneumoniae. To determine immune effectiveness vaccination...
Although mesenchymal stromal cells (MSCs) possess immunomodulatory properties and exhibit promising efficacy against chronic graft-versus-host disease (cGVHD), little is known about the immune changes by which MSCs ameliorate cGVHD in vivo. Recent studies have suggested that B lymphocytes might play an important role pathogenesis of cGVHD. In this study, we investigated numbers, phenotypes, subpopulations patients who showed a complete response (CR), partial (PR), or no (NR) after MSC...
Placenta-specific 1 (PLAC1), a novel cancer-testis antigen (CTA), is expressed in number of different human malignancies. It frequently produced breast cancer, serving function tumorigenesis. Adoptive immunotherapy using T cell receptor (TCR)-engineered cells against CTA mediates objective tumor regression; however, to the best our knowledge, targeting PLAC1 engineered has not yet been attempted. In present study, cDNAs encoding TCRα- and β-chains specific for leukocyte...
This study aimed to determine the performance and long-term outcomes of therapeutic ERCP in very old patients. Patients aged or over 90 (Group A, n = 78) consecutive sex-matched controls B, 312) under 65 selected were compared. More patients Group A had chronic concomitant diseases, but success complication rates comparable. The follow-up 61 (78.2%) done, with a mean period 27.5 (3-54) months. Seven survived; main causes death for other diseases (n 43) primary 11). In choledocholithiasis,...
KRAS mutations are prevalent in patients with pancreatic ductal adenocarcinoma (PDAC) and critical to fostering tumor growth part by aberrantly rewiring glucose, amino acid, lipid metabolism. Obesity is a modifiable risk factor for cancer. Corroborating this epidemiological observation, mice harboring mutant highly vulnerable obesogenic high-fat diet (HFD) challenges leading the development of PDAC high penetrance. However, contributions other macronutrient diets, such as diets rich...
Objective: Human umbilical cord mesenchymal stem cells (hUC-MSCs) have shown very attractive potential in clinical applications for the treatment of various diseases. However, data about reproductive and developmental toxicity hUC-MSCs remains insufficient. Thus, we assessed effects intravenous injection on reproduction development Sprague-Dawley rats. Methods: In fertility early embryonic study, were administered at dose levels 0, 6.0 × 106, 8.5 1.2 107/kg to male female rats during...