A5101777610- Cancer-related molecular mechanisms research
- Tissue Engineering and Regenerative Medicine
- Caveolin-1 and cellular processes
- Electrospun Nanofibers in Biomedical Applications
- Congenital heart defects research
- Estrogen and related hormone effects
- Cell Adhesion Molecules Research
- Mesenchymal stem cell research
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Cardiomyopathy and Myosin Studies
- Ferroptosis and cancer prognosis
- Phytochemicals and Antioxidant Activities
- RNA Research and Splicing
- Pluripotent Stem Cells Research
- Extracellular vesicles in disease
- Nutritional Studies and Diet
- Tea Polyphenols and Effects
- Angiogenesis and VEGF in Cancer
- Ion Transport and Channel Regulation
- Cholesterol and Lipid Metabolism
- Pain Mechanisms and Treatments
- Muscle Physiology and Disorders
- Circular RNAs in diseases
- Nicotinic Acetylcholine Receptors Study
Sun Yat-sen University
2010-2024
Yale University
2019-2020
The First Affiliated Hospital, Sun Yat-sen University
2019
Yale Cancer Center
2019
Individuals with prehypertension are at risk of hypertension and cardiovascular diseases, yet efficient interventions lagging behind. Studies indicate that heart rate variability-biofeedback (HRV-BF) increases HRV baroreflex sensitivity (BRS) as well reduces related pathological symptoms, suggesting potentially beneficial effects HRV-BF on prehypertension, but little is known about these effects. In this study, were investigated their mechanisms explored.The effect in young adults its...
Although stem cell-derived exosomes have been recognized as new candidates for cell-free treatment in myocardial infarction (MI), the challenge to improve exosome retention ischemic tissue remains. Our previous research indicated that islet-1(ISL1) overexpression enhances paracrine function of mesenchymal cells (MSCs) and promotes angiogenesis a model MI. In this study, genetically engineered ISL1-MSC-derived (ISL1-MSCs-Exo) were collected, contents analyzed by exosomal RNA sequencing. Next,...
Estrogen promotes breast cancer metastasis. However, the detailed mechanism remains largely unknown. The actin binding protein ezrin is a key component in tumor metastasis and its over-expression positively correlated to poor outcome of cancer. In this study, we investigate effects 17β-estradiol (E2) on activation role estrogen-dependent cell movement. T47-D cells, E2 rapidly enhances phosphorylation at Thr(567) time- concentration-dependent manner. signalling cascade implicated action...
Dilated cardiomyopathy (DCM) is a leading cause of heart failure and the primary indication for transplantation. The intricate poorly elucidated pathogenesis genetic DCM, coupled with paucity effective therapeutic options, imposes substantial burden on both patients their families. In this study, we identified novel MYBPC3 mutation (c.194C>T) in patient diagnosed DCM established patient-specific human induced pluripotent stem cell (hiPSC) model. Cardiomyocytes derived from these hiPSCs...
Mesenchymal stem cells (MSCs) are a promising cell resource for the treatment of ischemic diseases, partially through paracrine effects. One major obstacles MSC is poor survival rate and low efficiency transplanted due to or inflammatory environments. Gremlin1 (GREM1), regulator growth, differentiation development, has been identified as novel proangiogenic factor. However, role mechanism GREM1 in MSCs remains unclear. Therefore, we assessed putative beneficial effects on MSC-based therapy...
Backgroud/Aims: Mesenchymal stromal cells (MSCs) are a major component of the tumor microenvironment (TME). Several studies focusing on tumor-derived MSCs have demonstrated that they exhibit strong ability to promote epithelial-mesenchymal transition (EMT). However, factors mediating these effects poorly understood. Methods: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and immunohistochemistry assays were used detect expression Gremlin1 (GREM1) in human esophageal...
Controversy still exists that whether clopidogrel should add proton pump inhibitors (PPIs) in patients with coronary heart disease after percutaneous intervention (PCI). The aim of this study was to evaluate the efficacy and safety added vs. for treatment We systematically searched PubMed, EMBASE, Web Science, Chinese Biomedical Medical Literature database, Cochrane Library all clinical trials were published on topic through October 2018. specifically selected evaluated PCI. RevMan 5.0...
Atherosclerosis is an inflammatory disease where lipopolysaccharide (LPS) triggers the release of cytokines that accelerate its initiation and progression. Estrogen has been proven to be vasoprotective against atherosclerosis; however, anti-inflammatory function estrogen in vascular system remains obscure. In this study, we investigated effect on LPS-induced monocyte chemoattractant protein-1 (MCP-1; listed as CCL2 MGI database) production smooth muscle cells (VSMCs). LPS significantly...
Abstract The mechanisms of progesterone on endothelial cell motility are poorly investigated. Previously we showed that stimulated migration via the activation actin‐binding protein moesin, leading to actin cytoskeleton remodelling and formation membrane structures required for movement. In this study, investigated effects focal adhesion complexes, which provide anchoring sites cultured human umbilical cells, enhanced kinase (FAK) phosphorylation at Tyr 397 in a dose‐ time‐dependent manner....
The LIM-homeobox transcription factor islet-1 (ISL1) has been proposed as a marker for cardiovascular progenitor cells. This study investigated whether forced expression of ISL1 in human mesenchymal stem cells (hMSCs) improves myocardial infarction (MI) treatment outcomes. lentiviral vector containing the elongation 1α promoter, which drives (EF1α-ISL1), was constructed using Multisite Gateway System and used to transduce hMSCs. Flow cytometry, immunofluorescence, Western blotting, TUNEL...
Abstract Prostate cancer (PCa) is the third most common reason of cancer‐related deaths in men. Accumulating evidence has shown that dysregulation long noncoding RNAs (lncRNAs) closely related to initiation and development. Although large numbers lncRNAs have been discovered, knowledge regarding their function physiological/pathological significance remains limited. In this study, we aimed reveal functional identify prognosis‐related PCa by analyzing data from The Cancer Genome Atlas (TCGA)....
Inflammation and oxidative stress induced by oxidized low density lipoprotein are the main causes of vascular endothelial injury atherosclerosis. Endothelial cells important for formation repair blood vessels. However, detailed mechanism underlying regulation maturity antioxidation stem cell-derived like remains unclear. Besides, YY1 TET2 play a key role on epigenetic modifications proliferation differentiation cells. regulatory modification to iECICs is also not clear.Here, we want...
To explore the association between green tea consumption and coronary arterial disease (CAD) in Chinese population of Guangzhou. Design, location, subjects: A retrospective study at Sun Yat-sen Memorial Hospital Guangzhou, China. Consecutive patients were enrolled January 2013 August 2014. total 539 included. Two hundred sixty-seven them are CAD 272 non-CAD patients. The diagnosed according to international diagnostic criteria.Using data from questionnaires clinical laboratories, we...
Abstract Tumour necrotic factor receptor‐2 (TNFR2) has been to be cardiac‐protective and is expressed in cardiac progenitor cells. Our goal define the mechanism for TNFR2‐mediated stem cell activation differentiation. By employing a protocol of vitro (CSC) differentiation from human inducible pluripotent (hiPSC), we show that expression TNFR2 precedes CSC markers followed by mature cardiomyocyte proteins. Activation specific agonist promotes whereas inhibition neutralizing antibody...
Accumulating evidence indicates that the N6-methyladenosine (m 6 A) modification plays a critical role in human cancers. Given current understanding of m A modification, this process is believed to be dynamically regulated by regulators. Although discovery regulators has greatly enhanced our mechanism underlying cancers, function and context prostate cancer (PCa) remain unclear. Here, we aimed establish comprehensive diagnostic scoring model can act as complement prostate-specific antigen...
The association between tea consumption and risk of coronary heart disease (CHD) remains controversial. This study aimed to determine whether has an effect on CHD in Chinese adults.In this hospital-based case-control study, 267 cases 235 non-CHD controls were enrolled. Blood samples from all examined. Cardiac function indices (left ventricular ejection fraction, left end-diastolic dimension, lactate dehydrogenase, creatine kinase the muscle or brain type), blood lipid index (high-density...
Reliability in cell type annotation is challenging single-cell RNA-sequencing data analysis because both expert-driven and automated methods can be biased or constrained by their training data, especially for novel rare types. Although large language models (LLMs) are useful, our evaluation found that only a few matched expert annotations due to sources inflexible inputs. To overcome these limitations, we developed the LICT (Large model-based Identifier Cell Types) software package using...