A5050076476- Extracellular vesicles in disease
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Heavy Metal Exposure and Toxicity
- Nanoparticles: synthesis and applications
- Chemotherapy-induced cardiotoxicity and mitigation
- Ruminant Nutrition and Digestive Physiology
- Cardiovascular Disease and Adiposity
- Viral Infectious Diseases and Gene Expression in Insects
- Air Quality and Health Impacts
- Cardiac Fibrosis and Remodeling
- Cardiovascular Effects of Exercise
- Lymphoma Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Vitamin D Research Studies
- Atherosclerosis and Cardiovascular Diseases
- Noise Effects and Management
- Bone and Dental Protein Studies
- Sulfur Compounds in Biology
- Childhood Cancer Survivors' Quality of Life
- Aortic aneurysm repair treatments
- Protease and Inhibitor Mechanisms
- Trace Elements in Health
- Pasture and Agricultural Systems
- Climate Change and Health Impacts
Southern Medical University
2020-2024
Dongguan People’s Hospital
2022-2024
Zhujiang Hospital
2020-2024
Zhengzhou Institute of Machinery
2024
Guangdong Provincial Center for Disease Control and Prevention
2022
Key Laboratory of Guangdong Province
2021
Abstract Extracellular vesicles have shown good potential in disease treatments including ischemic injury such as myocardial infarction. However, the efficient production of highly active extracellular is one critical limitations for their clinical applications. Here, we demonstrate a biomaterial-based approach to prepare high amounts with bioactivity from endothelial progenitor cells (EPCs) by stimulation silicate ions derived bioactive ceramics. We further show that hydrogel microspheres...
Although stem cell-derived exosomes have been recognized as new candidates for cell-free treatment in myocardial infarction (MI), the challenge to improve exosome retention ischemic tissue remains. Our previous research indicated that islet-1(ISL1) overexpression enhances paracrine function of mesenchymal cells (MSCs) and promotes angiogenesis a model MI. In this study, genetically engineered ISL1-MSC-derived (ISL1-MSCs-Exo) were collected, contents analyzed by exosomal RNA sequencing. Next,...
Currently, stem cell transplantations in cardiac repair are limited owing to disadvantages, such as immunological rejection and poor viability. Although direct injection of exosomes can have a curative effect similar that transplantation, high clearance hinders its application clinical practice. Previous reports suggested induction coronary collateralization be desired method adjunctive therapy for someone who had missed the optimal operation time attenuate myocardial ischemia. In this...
Excessive or persistent inflammation incites cardiomyocytes necrosis by generating reactive oxygen species in myocardial infarction (MI). Hydrogen sulfide (H
Background The temporal trend of cardiovascular disease (CVD) mortality in patients with classic Hodgkin lymphoma (cHL) throughout follow‐up remains unclear. This study aimed to assess this cHL. Methods multicenter cohort included 15,889 cHL diagnosed between 1983 and 2015, covering all ages. proportional ratio, cumulative incidence cause‐specific accounting for competing risk, standard absolute excess risk were analyzed. Results Among stage I II cHL, the ratio CVD exceeded that after...
Abstract The high incidence of restenosis after angioplasty has been the leading reason for recurrence coronary heart disease, substantially increasing mortality risk patients. However, current anti‐stenosis drug‐eluting stents face challenges due to their limited functions and long‐term safety concerns, significantly compromising therapeutic effect. Herein, a stent‐free drug coating (denoted as Cur‐NO‐Gel) based on peptide hydrogel is proposed. This formed by assembling nitric oxide (NO)...
Abstract Atherosclerosis can form intimal plaques in the arteries and undergo plaque rupture with followed stroke or myocardial infarction under certain pathological conditions. However, suboptimal intraplaque accumulation, along severe off‐target effects, remain formidable obstacles for efficient pharmacotherapy of atherosclerosis. A characteristic feature progression atherosclerosis is continuous recruitment inflammatory monocytes that differentiate into foamy macrophages generation...
Abstract The fine particulate matter (PM2.5) in air pollution is a critical risk factor influencing human health. Our study included 8144 participants and showed that the of major adverse cardiovascular events increases by 35% (HR, 1.35; 95% CI, 1.14–1.60) for with highest quartile to PM2.5 exposure as compared those lowest quartile. Bioaerosols, an important environmental PM2.5, can induce systemic chronic inflammation leading vascular aging. Thus, effects bioaerosols are investigated from...
Chronic cadmium (Cd) exposure contributes to the progression of cardiovascular disease (CVD), especially atherosclerosis (AS), but underlying mechanism is unclear. Since mitochondrial homeostasis emerging as a core player in development CVD, it might serve potential linking Cd and AS. In this study, we aimed investigate Cd-mediated AS through macrophage polarization know mechanisms Cd-caused imbalance. vitro, flow cytometry shows that promotes M1-type macrophages, manifested increasing...
Fungal probiotics have the potential as feed additives, but less has been explored in ruminant up to date. This study aimed determine effect of compound (CPs) with Aspergillus oryzae 1, 2 and Candida utilis on Hu sheep’s growth performance, rumen fermentation microbiota. A total 120 male sheep, aged months body weight 16.95 ± 0.65 kg were divided into 4 groups. Each group consisted 5 replicates, 6 sheep per replicate. Group was control fed basal diet. B, C D supplemented diet by adding 400,...
Abstract Background : Chronic cadmium (Cd) exposure can contribute to the progression of cardiovascular disease (CVD), especially atherosclerosis (AS), but underlying mechanism is unclear. Since mitochondrial homeostasis emerging as a core player in development CVD, it might serve potential linking Cd and AS. Here, we aimed investigate Cd-induced AS through macrophage polarization tried find out dysfunction caused by exposure. Methods results: In vitro, flow cytometry showed that markedly...