A5100357491- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Cancer-related molecular mechanisms research
- Genetic Syndromes and Imprinting
- Birth, Development, and Health
- Circular RNAs in diseases
- Plant Disease Resistance and Genetics
- Nuts composition and effects
- RNA modifications and cancer
- Metabolism and Genetic Disorders
- Cancer-related gene regulation
- Plant Disease Management Techniques
- Extracellular vesicles in disease
- RNA Research and Splicing
- PI3K/AKT/mTOR signaling in cancer
- Vector-borne infectious diseases
- RNA regulation and disease
- Viral Infections and Vectors
- Plant Pathogens and Fungal Diseases
- Monoclonal and Polyclonal Antibodies Research
- Cannabis and Cannabinoid Research
- Mitochondrial Function and Pathology
- Chronic Lymphocytic Leukemia Research
Leiden University Medical Center
2023-2024
South China University of Technology
2019-2022
New York Blood Center
2022
Bioscience (China)
2021
Abstract Background Loss of epigenetic control is a hallmark aging. Among the most prominent roles mechanisms inactivation one two copies X chromosome in females through DNA methylation. Hence, age-related disruption X-chromosome (XCI) may contribute to aging process women. Methods We analyzed 9,777 CpGs on whole blood samples from 2343 and 1688 males (Illumina 450k methylation array) replicated findings duplicate using purified monocyte data set (in total, 991/924 females/males). used...
Introduction Dark septate endophytes (DSEs) commonly colonize plant roots in heavy metal-polluted habitats, but little is known about the potential mechanisms driving medicinal plants to adapt environments. Here, we investigated growth of Paraboeremia selaginellae strains and their enhancing cadmium (Cd) tolerance Salvia miltiorrhiza Cd-contaminated soil. Methods First, tested Cd resistance P. by vitro culture. Then, studied performance S. inoculated with Results It was found that possessed...
Abstract Prostate cancer (PCa) is the third most common reason of cancer‐related deaths in men. Accumulating evidence has shown that dysregulation long noncoding RNAs (lncRNAs) closely related to initiation and development. Although large numbers lncRNAs have been discovered, knowledge regarding their function physiological/pathological significance remains limited. In this study, we aimed reveal functional identify prognosis‐related PCa by analyzing data from The Cancer Genome Atlas (TCGA)....
Babesiosis is a zoonosis and an important blood-borne human parasitic infection that has gained attention because of its growing rate in humans by transfer from animal reservoirs. Babesia represents potential threat to the blood supply asymptomatic infections man are common, such donors can cause severe disease certain recipients. Extracellular vesicles (EVs) released cells contain complex mixture proteins, lipids, glycans, genetic information have been shown play roles pathogenesis...
Coronary artery disease (CAD) is considered one of the leading causes death worldwide. Although dysregulation long non-coding RNAs (lncRNAs) has been reported to be associated with initiation and progression CAD, knowledge regarding their specific functions as well physiological/pathological significance in CAD very limited. In this study, we aimed systematically analyze immune-related lncRNAs explore relationship between key immune cell infiltration process. Based on differential expression...
Accumulating evidence indicates that the N6-methyladenosine (m 6 A) modification plays a critical role in human cancers. Given current understanding of m A modification, this process is believed to be dynamically regulated by regulators. Although discovery regulators has greatly enhanced our mechanism underlying cancers, function and context prostate cancer (PCa) remain unclear. Here, we aimed establish comprehensive diagnostic scoring model can act as complement prostate-specific antigen...
Summary The epigenetic regulation of clustered protocadherin (c PCDH ) genes is tightly linked to their function as specific cell surface barcodes for neural self-nonself discrimination. Differential c DNA methylation in both blood and brain has been implicated diverse human traits diseases ranging from BMI, aging, cancer disorders. However, the unique remains poorly understood. Therefore, we performed a genome-wide association study evaluate >7 million genetic variants with at 607 CpGs...
Bruton's tyrosine kinase (BTK) plays a vital role in mature B-cell proliferation, development and function. Its inhibitors have gradually been applied for the treatment of many malignancies. However, because treatment-associated drug resistance or low efficacy, it is urgent to develop new and/or improve efficacy current inhibitors, where finding intrinsic activation mechanism becomes key solve this problem. Here, we used BTK T474M mutation as model study by free molecular dynamics...
Abstract Background Loss of epigenetic control is a hallmark aging. Among the most prominent roles mechanisms inactivation one two copies X chromosome in females through DNA methylation. Hence, age-related disruption X-chromosome (XCI) may contribute to ageing process women. Methods We analyzed 9,777 CpGs on whole blood samples from 2343 and 1688 males. replicated findings duplicate using purified monocyte data set (in total, 991/924 females/males). used double generalized linear models...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)