A5014990062- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cleft Lip and Palate Research
- Genomics and Rare Diseases
- Immunodeficiency and Autoimmune Disorders
- Cannabis and Cannabinoid Research
- Health, Environment, Cognitive Aging
- Educational Games and Gamification
- Genetic Syndromes and Imprinting
- Blood disorders and treatments
- Vitamin D Research Studies
- Parkinson's Disease Mechanisms and Treatments
- Birth, Development, and Health
- GDF15 and Related Biomarkers
- Genetics and Neurodevelopmental Disorders
- Prenatal Screening and Diagnostics
- Ovarian cancer diagnosis and treatment
- HIV-related health complications and treatments
Leiden University Medical Center
2020-2024
Leiden University
2019
University of Eastern Finland
2015
Disruption of cell division cycle associated 7 (CDCA7) has been linked to aberrant DNA hypomethylation, but the impact methylation loss on transcription not investigated. Here, we show that CDCA7 is critical for maintaining global levels across multiple tissues in vivo. A pathogenic
Vitamin D3 has transcriptome- and genome-wide effects activates, via the binding of its metabolite 1α,25-dihydroxyvitamin to transcription factor vitamin D receptor (VDR), several hundred target genes. Using samples from a 5-month intervention study (VitDmet), we recently reported that expression 12 VDR genes in peripheral blood mononuclear cells (PBMCs) as well biochemical clinical parameters participants are significantly triggered by D3. In this study, performed more focused selection...
Cell fate decisions are orchestrated by an interplay of epigenetic factors in collaboration with transcriptional activators and repressors. The reader MORC3 is known as a silencer endogenous retroviruses mouse embryonic stem cells. Here, we show that expressed the thymus reveal loss function leads to severe arrest T cell development at DN1 stage, accompanied expansion natural killer myeloid depends on its ATPase ability bind H3K4me via CW-type zinc finger domain. We find altered chromatin...
ABSTRACT DNA methylation is a key epigenetic modification essential for normal development. How particular factors control patterns and activity of given locus incompletely understood. The zinc finger protein Zbtb24 has been implicated in transcriptional activation/repression the maintenance pathway. Here, using whole genome bisulfite sequencing mouse embryonic stem cells, we report that besides general trend towards hypomethylation, many genomic sites gain absence they include promoters...
Summary The epigenetic regulation of clustered protocadherin (c PCDH ) genes is tightly linked to their function as specific cell surface barcodes for neural self-nonself discrimination. Differential c DNA methylation in both blood and brain has been implicated diverse human traits diseases ranging from BMI, aging, cancer disorders. However, the unique remains poorly understood. Therefore, we performed a genome-wide association study evaluate >7 million genetic variants with at 607 CpGs...