A5034383020- Dietary Effects on Health
- Diet and metabolism studies
- Gut microbiota and health
- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Circadian rhythm and melatonin
- Gastrointestinal motility and disorders
- Nutrition and Health in Aging
- Muscle metabolism and nutrition
- Liver Disease and Transplantation
- Educational Games and Gamification
- Nutritional Studies and Diet
- Diet, Metabolism, and Disease
- Clostridium difficile and Clostridium perfringens research
Leiden University Medical Center
2022-2025
Background: Lifestyle interventions, such as diet and exercise, are currently the main therapies against metabolic dysfunction-associated steatotic liver disease (MASLD). However, not much is known about combined impact of fiber exercise on modulation gut-liver axis MASLD amelioration. Here, we studied combination training a fiber-rich amelioration MASLD. Methods: Male APOE*3-Leiden.CETP mice were fed high-fat high-cholesterol with or without addition (10% inulin) trained treadmill, remained...
Cell fate decisions are orchestrated by an interplay of epigenetic factors in collaboration with transcriptional activators and repressors. The reader MORC3 is known as a silencer endogenous retroviruses mouse embryonic stem cells. Here, we show that expressed the thymus reveal loss function leads to severe arrest T cell development at DN1 stage, accompanied expansion natural killer myeloid depends on its ATPase ability bind H3K4me via CW-type zinc finger domain. We find altered chromatin...
The metabolic and inflammatory processes that are implicated in the development of cardiovascular diseases under control biological clock. While skeletal muscle function exhibits circadian rhythms, it is unclear to what extent beneficial health effects exercise restricted unique time windows. We aimed study whether timing training differentially modulates atherosclerosis elucidate underlying mechanisms. endurance-trained atherosclerosis-prone female APOE*3-Leiden.CETP mice fed a Western-type...
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects two billion people worldwide and is currently mostly treatable via lifestyle interventions, such as exercise training. However, it unclear whether the positive effects of are restricted to unique circadian windows. We therefore aimed study timing training differentially modulates MASLD development. Twenty weeks old male APOE*3‐Leiden.CETP mice were fed a high fat‐high cholesterol diet induce treadmill‐trained...
Abstract Exercise is generally beneficial for health but strenuous exercise can have detrimental effects on the gastrointestinal tract. The combination of ischemia and heat shock during a crucial contributor to intestinal epithelial damage. Growing evidence points towards an important regulatory role gut microbes in homeostasis. Here, we characterize compare moderate vigorous training damage, stress response, inflammatory microbiota alterations mice investigate mechanisms underlying...
Exercise is generally beneficial for health but strenuous exercise can have detrimental effects on the gastrointestinal tract. The combination of ischemia and heat shock during a crucial contributor to intestinal epithelial damage. Growing evidence points towards an important regulatory role gut microbes in homeostasis. Here, we characterize compare moderate vigorous training damage, stress response, inflammatory microbiota alterations mice investigate mechanisms underlying exercise-induced...
Exercise is generally beneficial for health but strenuous exercise can have detrimental effects on the gastrointestinal tract. The combination of ischemia and heat shock during a crucial contributor to intestinal epithelial damage. Growing evidence points towards an important regulatory role gut microbes in homeostasis. Here, we characterize compare moderate vigorous training damage, stress response, inflammatory microbiota alterations mice investigate mechanisms underlying exercise-induced...
Abstract The metabolic and inflammatory processes that are implicated in the development of cardiovascular diseases under control biological clock. While skeletal muscle function exhibits circadian rhythms, it is unclear to what extent beneficial health effects exercise restricted unique time windows. We aimed study whether timing training differentially modulates atherosclerosis elucidate underlying mechanisms. endurance-trained atherosclerosis-prone female APOE*3-Leiden.CETP mice fed a...
Abstract Exercise effectively prevents obesity-related disorders, but it is unclear whether the beneficial health effects of exercise are restricted to unique circadian windows. Therefore, we aimed study timing training differentially modulates development and progression non-alcoholic fatty liver disease (NAFLD), a currently estimated affect over two billion people worldwide. We endurance-trained high fat-high cholesterol-fed NAFLD-prone male APOE*3-Leiden.CETP mice five times per week for...